MARCELLO MENTA SIMONSEN NICO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Dermatologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina
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article 14 Citação(ões) na Scopus MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma(2015) FERNANDES, Juliana D.; HSIEH, Ricardo; FREITAS, Luiz A. R. de; BRANDAO, Miguel A. R.; LOURENCO, Silvia V.; SANGUEZA, Martin; NICO, Marcello M. S.The etiology and pathogenesis of lentiginous acral melanomas are poorly understood. Recent studies have postulated that DNA repair mechanisms and cell growth pathways are involved in the development of melanoma, particularly changes in the MAPK pathways (RAS, BRAF, MEK 1/2, and ERK 1/2). The aim of this study is to assess the status of the MAP kinase pathways in the pathogenesis of acral melanomas. The authors examined the components of the RAS-RAF-MEK-ERK cascades by immunohistochemistry in a series of 16 primary acral melanomas by tissue microarray. The expression of MAP kinase cascade proteins changed in most cases. The authors observed that 57.14% of cases were BRAF positive and that 61.53%, 71.42%, and 71.42% of cases were positive for MEK2, ERK1, and ERK2, respectively; RAS was not expressed in 92.31%, and all cases were negative for MEK1. The absence of RAS and positivity for MEK2, ERK1, and ERK2 were most seen in invasive cases with high thickness. These aspects of the MAPK pathway require further examination in acral melanomas between different populations. Nevertheless, the results highlight significant alterations in the MAP kinase cascades that are related to histological indicators of prognosis in primary acral melanomas.conferenceObject Sclerosing lipogranuloma with multiple skin lesions associated with pulmonary involvement and secondary to a factitious disorder-case report and review(2015) TIRICO, Maria; NICO, Marcello; NETO, CyroconferenceObject Preliminary Proteomic Analysis of Saliva from Patients with Sjogren's Syndrome(2015) BOLOGNA, S. B.; SOUZA, M. M.; NUNES, T. B.; NICO, M. M. S.; PASOTO, S. G.; LOURENCO, S. V.- Periungual furuncular myiasis: easily overlooked(2015) SILVA, Lana Luiza Da; LOMAQUIZ, Christian D. Cardozo; NICO, Marcello Menta Simonsen
bookPart Manifestações orais na doença inflamatória intestinal(2015) NICO, Marcelo Menta Simonsen; BOLOGNA, Sheyla Batista; LOURENçO, Silvia Vanessa- Persistent eyelid edema and erythema as manifestation of lupus erythematosus: a series of six cases(2015) SILVA, Lana Luiza da Cruz; ROMITI, Ricardo; NICO, Marcello Menta Simonsen
- Actinomycetoma of the scalp due to Nocardia brasiliensis: case report and review of the literature(2015) ZUNIGA, Miguel; HUNZIKER, Maria Fernanda; NICO, Marcello Menta; RIVITTI, Evandro Ararigboia; FESTA-NETO, Cyro
article 9 Citação(ões) na Scopus In Vivo Reflectance Confocal Microscopy Evaluation of Cheilitis Glandularis: A Report of 5 Cases(2015) LOURENCO, Silvia V.; KOS, Eliana; NUNES, Thais Borguezan; BOLOGNA, Sheyla B.; SANGUEZA, Martin; NICO, Marcello M. S.Cheilitis glandularis (CG) is an uncommon condition of unknown origin; it is clinically characterized by variable degrees of macrocheilia associated with red dilated ostia of minor salivary glands on the vermilion area, which secrete viscous saliva. Histopathological characteristics of CG are comprised of chronic sialadenitis with engorged acinar lobules and dilated ducts; CG also features chronic sun damage (actinic cheilitis and squamous cell carcinoma). These changes may be localized, and a punch biopsy specimen might fail to reveal enough criteria to support the diagnosis of CG. Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that enables an in vivo en face visualization of tissues with a resolution close to conventional histopathology. Its use allows analysis of the entire lip, without excision. We reported the evaluation of 5 cases of CG based on clinical RCM and histopathological correlation. RCM examination of the lip vermilion mainly revealed a bright aspect of the superficial epithelial layers, which corresponded to labial keratosis. Alteration of the classical epithelial honeycomb pattern was observed in RCM, which corresponded to epithelial changes in actinic cheilitis at histopathology. Round, dark empty spaces intermingling the epithelium, corresponded to the ectopic excretory salivary gland ducts that open their ostia within the lip vermilion. In the lamina propria, the most striking feature was superficial salivary gland lobules, seen as dark gray lobular structures. Our study, demonstrated the use of RCM in the evaluation of CG, showing that a correlation between the clinical, digital RCM images and histopathology improved the diagnostic skills in CG evaluation.bookPart Manifestações orais na doença inflamatória intestinal(2015) NICO, Marcello Menta Simonsen; BOLOGNA, Sheyla Batista; LORENçO, Silvia Vanessa