MARCELLO MENTA SIMONSEN NICO

(Fonte: Lattes)
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Lattes
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Unidades Organizacionais
Departamento de Dermatologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina

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  • article 0 Citação(ões) na Scopus
    Delusional infestation treated with risperidone: a series of 27 patients
    (2024) GUEDES, Nycolle L. K. O.; DWAN, Alexandre J.; GERLERO, Paula; NICO, Marcello M. S.
    Background Patients with delusional infestation (DI) frequently refuse to be treated with psychoactive drugs. In the past, pimozide was commonly used as a first-line agent but is now prescribed more rarely. Risperidone was first used to treat DI in 1995. A recent review identified 12 studies that evaluated the use of risperidone in 43 patients with DI.Objectives To study the characteristics of and therapeutic results in patients with DI treated with risperidone at a university medical centre in Sao Paulo, Brazil.Methods We performed a retrospective study of patients with DI treated with risperidone at a dermatological university clinic since 2016. Records were reviewed for personal data and findings related to treatment.Results Twenty-seven patients were studied (20 women and 7 men). The maintenance dose of risperidone varied from 1 mg three times weekly to 8 mg daily. Control of symptoms was achieved in the majority of patients. A reduction in dosage due to side-effects was seen in four patients; risperidone had to be switched to another antipsychotic in three cases, despite a good response. Only one patient did not respond to risperidone.Conclusions Risperidone is an effective, well-tolerated and safe treatment for delusional parasitosis. Adequate follow-up is mandatory in order to obtain long-term control of symptoms. Patients with delusional infestation (DI) frequently refuse to be treated with psychoactive drugs. Risperidone was first used to treat DI in 1995. A recent review identified 12 studies evaluating risperidone, with a total of 43 patients with DI. We studied the characteristics and therapeutic results in 27 patients with DI treated with risperidone in a university medical centre in Sao Paulo, Brazil. Control of symptoms was achieved in the majority. Risperidone is an effective, well-tolerated and safe treatment for DI. Adequate follow-up is mandatory to obtain long-term control of symptoms.
  • article 0 Citação(ões) na Scopus
    Histopathologic findings in ointment pseudo-cheilitis: An alert to dermatopathologists
    (2024) NICO, Marcello Menta Simonsen; SIERRA, Jose Ollague; MOYA, Fernanda Goncalves; LOURENCO, Silvia Vanessa
    Ointment pseudo-cheilitis is a recently recognized distinctive type of self-induced cheilitis. Lesions consist of a variable amount of crusts adhered to the vermilion. These crusts consist of dried saliva and dead cells mixed with applied medications attached to the lip surface. Patients are typically severely anxious or depressed; the condition impacts quality of life. Ointment pseudo-cheilitis is frequently misdiagnosed as exfoliative cheilitis or cheilitis glandularis. Biopsy reports are often non-revealing because there are no established histopathological criteria for this disease, and clinicians usually do not formulate the correct diagnostic hypothesis. Here, we present the histopathological findings of four cases of ointment pseudo-cheilitis. The most consistent finding was the presence of laminated parakeratotic material detached from the epithelium in biopsies that are devoid of other significant diagnostic changes. This material at the lip surface possibly represents physiologic labial desquamation mixed with dried saliva and applied medication. With this report, we intend to alert dermatopathologists to the diagnosis of ointment pseudo-cheilitis if they receive biopsies from patients who present clinically exuberant labial lesions that show only minimal histopathological changes.