BRUNO RODRIGUES
Projetos de Pesquisa
Unidades Organizacionais
2 resultados
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- Ventricular and autonomic benefits of exercise training persist after detraining in infarcted rats(2013) BARBOZA, Catarina Andrade; ROCHA, Leandro Yanase; MOSTARDA, Cristiano Teixeira; FIGUEROA, Diego; CAPERUTO, Erico Chagas; ANGELIS, Katia De; IRIGOYEN, Maria Claudia; RODRIGUES, BrunoWe evaluate the effects of detraining (DT, for 1 month) on the left ventricular (LV) remodeling and function, hemodynamic and baroreflex sensitivity (BRS), as well as on mortality rate of infarcted (MI) rats after 3 months of exercise training (ET, 50-70 % of VO2max). Male Wistar rats were divided into five groups: control (C, n = 10), untrained-infarcted (UI, n = 15), trained-infarcted (TI, n = 12), untrained-infarcted plus 1 month (UI-1, n = 15) and detrained-infarcted 1 month (DI-1, n = 15). LV function was evaluated by echocardiography at the initial and final of the protocols. After following, ET and/or DT protocols, hemodynamic and BRS [by tachycardic (TR) and bradycardic (BR) responses] were assessed. TI group displayed increased VO2max in comparison with UI and DI-1 groups; however, DI-1 values remained increased compared to UI-1 group. MI area was reduced by ET and maintained after DT. Ejection fraction (TI = 60 +/- A 2 and DI-1 = 61 +/- A 2 % vs. UI = 41 +/- A 1 and UI-1 = 37 +/- A 3 %), E/A ratio (TI = 1.6 +/- A 0.1 and DI-1 = 1.9 +/- A 0.1 vs. UI = 2.9 +/- A 0.2 and UI-1 = 2.9 +/- A 0.3), TR (TI = 3.3 +/- A 0.3 and DI-1 = 3.3 +/- A 0.4 vs. UI = 1.7 +/- A 0.1 and UI-1 = 1.6 +/- A 0.1 bpm/mmHg) and BR (TI = -2.2 +/- A 0.1 and DI-1 = -2.0 +/- A 0.1 vs. UI = -1.3 +/- A 0.09 and UI-1 = -1.2 +/- A 0.09 bpm/mmHg) were improved by ET and maintained after DT in comparison with untrained rats. These changes resulted in mortality reduction in the TI (8 %) and DI-1 groups (13 %) compared with the UI (46 %) and UI-1 (53 %) groups. These findings indicate that ET is not only an effective tool in the management of cardiovascular and autonomic MI derangements, but also that these positive changes were maintained even after 1 month of DT in rats.
- Impact of myocardial infarction on cardiac autonomic function in diabetic rats(2013) RODRIGUES, Bruno; MOSTARDA, Cristiano T.; JORGE, Luciana; BARBOZA, Catarina A.; GRANS, Camilla F.; ANGELIS, Katia De; IRIGOYEN, Maria ClaudiaAims: We evaluated autonomic and hemodynamic parameters and maximal oxygen consumption (VO(2)max) as possible determinants of mortality in streptozotocin (STZ) diabetic rats after myocardial infarction (MI). Method: Male Wistar rats were divided into (n=8 of each): control sham (CS), diabetes sham (DS), MI (I), and diabetes +MI (DI). MI was induced 15 days after STZ induction. VO(2)max was measured at 3 (basal), 30, 60, and 91 days after MI. Hemodynamic and autonomic parameters were evaluated 92 days after MI. Results: MI area was similar in infarcted groups (similar to 44%). Mortality rate increased in the DI (70%) compared with I (53%) group. Cardiopulmonary baroreflex, sympathetic (48%) and vagal (33%) tonus, low frequency (LF) band (57%), and LF/high frequency (HF) band ratio (53%) were reduced in DI compared with I animals. Furthermore, cardiac output (CO), peripheral vascular resistance (PVR) impairment, and VO(2)max reductions were observed in the DI compared with the I group. Conclusions: Our data suggest that the CO and PVR changes as well as VO(2)max reduction were probably associated with additional cardiac autonomic control impairment, and, consequently, increased mortality rate in diabetic rats after a chronic myocardial infarction.