ANDRE DONG WON LEE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey(2020) PIRONI, Loris; STEIGER, Ezra; BRANDT, Chrisoffer; JOLY, Francisca; WANTEN, Geert; CHAMBRIER, Cecile; AIMASSO, Umberto; SASDELLI, Anna Simona; ZERASCHI, Sarah; KELLY, Darlene; SZCZEPANEK, Kinga; JUKES, Amelia; CARO, Simona Di; THEILLA, Miriam; KUNECKI, Marek; DANIELS, Joanne; SERLIE, Mireille; POULLENOT, Florian; WU, Jian; COOPER, Sheldon C.; RASMUSSEN, Henrik H.; COMPHER, Charlene; SEGUY, David; CRIVELLI, Adriana; PAGANO, Maria C.; HUGHES, Sarah-Jane; GUGLIELMI, Francesco W.; KOZJEK, Nada Rotovnik; SCHNEIDER, Stephane M.; GILLANDERS, Lyn; ELLEGARD, Lars; THIBAULT, Ronan; MATRAS, Przemyslaw; ZMARZLY, Anna; MATYSIAK, Konrad; GOSSUM, Andre Van; FORBES, Alastair; WYER, Nicola; TAUS, Marina; VIRGILI, Nuria M.; O'CALLAGHAN, Margie; CHAPMAN, Brooke; OSLAND, Emma; CUERDA, Cristina; SAHIN, Peter; JONES, Lynn; LEE, Andre Dong Won; MASCONALE, Luisa; ORLANDONI, Paolo; LZBEKI, Ferenc; SPAGGIARI, Corrado; BUENO, Marta; DOITCHINOVA-SIMEONOVA, Maryana; GARDE, Carmen; SERRALDE-ZUNIGA, Aurora E.; OLVEIRA, Gabriel; KRZNARIC, Zeljko; CZAKO, Laszlo; KEKSTAS, Gintautas; SANZ-PARIS, Alejandro; JAUREGUI, Estrella Petrina; MURILLO, Ana Zugasti; SCHAFER, Eszter; ARENDS, Jann; SUAREZ-LLANOS, Jose P.; LAL, SimonBackground & aims: The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in their provision of HPN and the types of intravenous supplementation (IVS)-admixtures prescribed to patients with chronic intestinal failure (CIF). Methods: In March 2015, 65 centers from 22 countries enrolled 3239 patients (benign disease 90.1%, malignant disease 9.9%), recording the patient, CIF and HPN characteristics in a structured database. The HPN-provider was categorized as health care system local pharmacy (LP) or independent home care company (HCC). The IVS-admixture was categorized as fluids and electrolytes alone (FE) or parenteral nutrition, either commercially premixed (PA) or customized to the individual patient (CA), alone or plus extra FE (PAFE or CAFE). Doctors of HPN centers were responsible for the IVS prescriptions. Results: HCC (66%) was the most common HPN provider, with no difference noted between benign-CIF and malignant-CIF. LP was the main modality in 11 countries; HCC prevailed in 4 European countries: Israel, USA, South America and Oceania (p < 0.001). IVS-admixture comprised: FE 10%, PA 17%, PAFE 17%, CA 38%, CAFE 18%. PA and PAFE prevailed in malignant-CIF while CA and CAFE use was greater in benign-CIF (p < 0.001). PA + PAFE prevailed in those countries where LP was the main HPN-provider and CA + CAFE prevailed where the main HPN-provider was HCC (p < 0.001). Conclusions: This is the first study to demonstrate that HPN provision and the IVS-admixture differ greatly among countries, among HPN centers and between benign-CIF and cancer-CIF. As both HPN provider and IVS-admixture types may play a role in the safety and effectiveness of HPN therapy, criteria to homogenize HPN programs are needed so that patients can have equal access to optimal CIF care.
- Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey(2021) PIRONI, Loris; STEIGER, Ezra; JOLY, Francisca; JEPPESEN, Palle B.; WANTEN, Geert; SASDELLI, Anna S.; CHAMBRIER, Cecile; AIMASSO, Umberto; MUNDI, Manpreet S.; SZCZEPANEK, Kinga; JUKES, Amelia; THEILLA, Miriam; KUNECKI, Marek; DANIELS, Joanne; SERLIE, Mireille; POULLENOT, Florian; COOPER, Sheldon C.; RASMUSSEN, Henrik H.; COMPHER, Charlene; SEGUY, David; CRIVELLI, Adriana; SANTARPIA, Lidia; GUGLIELMI, Francesco W.; KOZJEK, Nada Rotovnik; SCHNEIDER, Stephane M.; ELLEGARD, Lars; THIBAULT, Ronan; MATRAS, Przemyslaw; MATYSIAK, Konrad; GOSSUM, Andre Van; FORBES, Alastair; WYER, Nicola; TAUS, Marina; VIRGILI, Nuria M.; O'CALLAGHAN, Margie; CHAPMAN, Brooke; OSLAND, Emma; CUERDA, Cristina; UDVARHELYI, Gabor; JONES, Lynn; LEE, Andre D. Won; MASCONALE, Luisa; ORLANDONI, Paolo; SPAGGIARI, Corrado; DIEZ, Marta Bueno; DOITCHINOVA-SIMEONOVA, Maryana; SERRALDE-ZUNIGA, Aurora E.; OLVEIRA, Gabriel; KRZNARIC, Zeljko; CZAKO, Laszlo; KEKSTAS, Gintautas; SANZ-PARIS, Alejandro; JAUREGUI, Ma Estrella Petrina; MURILLO, Ana Zugasti; SCHAFER, Eszter; ARENDS, Jann; SUAREZ-LLANOS, Jose P.; SU, P.; YOUSSEF, Nader N.; BRILLANTI, Giorgia; NARDI, Elena; LAL, SimonBackground and aims: The case-mix of patients with intestinal failure due to short bowel syndrome (SBSIF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries. Methods: The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1-2, 2-3 and >3 L/day. Results: In the entire group: 60.7% were females and SBS-J comprised 60% of cases, while mesenteric ischaemia (MI) and Crohn' disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50% of cases; IVS was infused >5 days/week in 75% and FE in 10% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75% or more of patients in UK and Denmark and 50-60% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland. Conclusions: SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.
- Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey(2018) PIRONI, Loris; KONRAD, Denise; BRANDT, Chrisoffer; JOLY, Francisca; WANTEN, Geert; AGOSTINI, Federica; CHAMBRIER, Cecile; AIMASSO, Umberto; ZERASCHI, Sarah; KELLY, Darlene; SZCZEPANEK, Kinga; JUKES, Amelia; CARO, Simona Di; THEILLA, Miriam; KUNECKI, Marek; DANIELS, Joanne; SERLIE, Mireille; POULLENOT, Florian; WU, Jian; COOPER, Sheldon C.; RASMUSSEN, Henrik H.; COMPHER, Charlene; SEGUY, David; CRIVELLI, Adriana; PAGANO, Maria C.; HUGHES, Sarah Jane; GUGLIELMI, Francesco W.; KOZJEK, Nada Rotovnik; SCHNEIDER, Stephane M.; GILLANDERS, Lyn; ELLEGARD, Lars; THIBAULT, Ronan; MATRAS, Przemyslaw; ZMARZLY, Anna; MATYSIAK, Konrad; GOSSUM, Andre Van; FORBES, Alastair; WYER, Nicola; TAUS, Marina; VIRGILI, Nuria M.; O'CALLAGHAN, Margie; CHAPMAN, Brooke; OSLAND, Emma; CUERDA, Cristina; SAHIN, Peter; JONES, Lynn; LEE, Andre D. W.; BERTASI, Valentino; ORLANDONI, Paolo; IZBEKI, Ferenc; SPAGGIARI, Corrado; DIEZ, Marta Bueno; DOITCHINOVA-SIMEONOVA, Maryana; GARDE, Carmen; SERRALDE-ZUNIGA, Aurora E.; OLVEIRA, Gabriel; KRZNARIC, Zeljko; CZAKO, Laszlo; KEKSTAS, Gintautas; SANZ-PARIS, Alejandro; JAUREGUI, Estrella Petrina; MURILLO, Ana Zugasti; SCHAFER, Eszter; ARENDS, Jann; SUAREZ-LLANOS, Jose R.; SHAFFER, Jon; LAL, SimonBackground & aims: The aim of the study was to evaluate the applicability of the ESPEN 16-category clinical classification of chronic intestinal failure, based on patients' intravenous supplementation (IVS) requirements for energy and fluids, and to evaluate factors associated with those requirements. Methods: ESPEN members were invited to participate through ESPEN Council representatives. Participating centers enrolled adult patients requiring home parenteral nutrition for chronic intestinal failure on March 1st 2015. The following patient data were recorded though a structured database: sex, age, body weight and height, intestinal failure mechanism, underlying disease, IVS volume and energy need. Results: Sixty-five centers from 22 countries enrolled 2919 patients with benign disease. One half of the patients were distributed in 3 categories of the ESPEN clinical classification. 9% of patients required only fluid and electrolyte supplementation. IVS requirement varied considerably according to the pathophysiological mechanism of intestinal failure. Notably, IVS volume requirement represented loss of intestinal function better than IVS energy requirement. A simplified 8 category classification of chronic intestinal failure was devised, based on two types of IVS (either fluid and electrolyte alone or parenteral nutrition admixture containing energy) and four categories of volume. Conclusions: Patients' IVS requirements varied widely, supporting the need for a tool to homogenize patient categorization. This study has devised a novel, simplified eight category IVS classification for chronic intestinal failure that will prove useful in both the clinical and research setting when applied together with the underlying pathophysiological mechanism of the patient's intestinal failure.
- Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure(2020) PIRONI, Loris; STEIGER, Ezra; JOLY, Francisca; WANTEN, Geert J. A.; CHAMBRIER, Cecile; AIMASSO, Umberto; SASDELLI, Anna Simona; SZCZEPANEK, Kinga; JUKES, Amelia; THEILLA, Miriam; KUNECKI, Marek; DANIELS, Joanne; SERLIE, Mireille J.; COOPER, Sheldon C.; POULLENOT, Florian; RASMUSSEN, Henrik Hojgaard; COMPHER, Charlene W.; CRIVELLI, Adriana; HUGHES, Sarah-Jane; SANTARPIA, Lidia; GUGLIELMI, Francesco William; KOZJEK, Nada Rotovnik; ELLEGARD, Lars; SCHNEIDER, Stephane M.; MATRAS, Przemyslaw; FORBES, Alastair; WYER, Nicola; ZMARZLY, Anna; TAUS, Marina; O'CALLAGHAN, Margie; OSLAND, Emma; THIBAULT, Ronan; CUERDA, Cristina; JONES, Lynn; CHAPMAN, Brooke; SAHIN, Peter; VIRGILI, Nuria M.; LEE, Andre Dong Won; ORLANDONI, Paolo; MATYSIAK, Konrad; CARO, Simona Di; DOITCHINOVA-SIMEONOVA, Maryana; MASCONALE, Luisa; SPAGGIARI, Corrado; GARDE, Carmen; SERRALDE-ZUNIGA, Aurora E.; OLVEIRA, Gabriel; KRZNARIC, Zeljko; JAUREGUI, Estrella Petrina; MURILLO, Ana Zugasti; SUAREZ-LLANOS, Jose P.; NARDI, Elena; GOSSUM, Andre Van; LAL, SimonBackground and aim No marker to categorise the severity of chronic intestinal failure (CIF) has been developed. A 1-year international survey was carried out to investigate whether the European Society for Clinical Nutrition and Metabolism clinical classification of CIF, based on the type and volume of the intravenous supplementation (IVS), could be an indicator of CIF severity. Methods At baseline, participating home parenteral nutrition (HPN) centres enrolled all adults with ongoing CIF due to non-malignant disease; demographic data, body mass index, CIF mechanism, underlying disease, HPN duration and IVS category were recorded for each patient. The type of IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorised as <1, 1-2, 2-3 and >3 L/day. The severity of CIF was determined by patient outcome (still on HPN, weaned from HPN, deceased) and the occurrence of major HPN/CIF-related complications: intestinal failure-associated liver disease (IFALD), catheter-related venous thrombosis and catheter-related bloodstream infection (CRBSI). Results Fifty-one HPN centres included 2194 patients. The analysis showed that both IVS type and volume were independently associated with the odds of weaning from HPN (significantly higher for PN 1 L/day), patients' death (lower for FE, p=0.079), presence of IFALD cholestasis/liver failure and occurrence of CRBSI (significantly higher for PN 2-3 and PN >3 L/day). Conclusions The type and volume of IVS required by patients with CIF could be indicators to categorise the severity of CIF in both clinical practice and research protocols.