HENRIQUE AYRES MAYRINK GIARDINI

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P ICHC, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina

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search.filters.applied.f.dateIssued: 2023 × Indexador: MEDLINE ×

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  • article 3 Citação(ões) na Scopus
    The administration of methotrexate in patients with Still's disease, ""real-life"" findings from AIDA Network Still Disease Registry
    (2023) RUSCITTI, Piero; SOTA, Jurgen; VITALE, Antonio; LOPALCO, Giuseppe; IANNONE, Florenzo; MORRONE, Maria; GIARDINI, Henrique Ayres Mayrink; D'AGOSTIN, Marilia Ambuel; ANTONELLI, Isabelle Parente de Brito; ALMAGHLOUTH, Ibrahim; ASFINA, Kazi Nur; KHALIL, Najma; SFIKAKIS, Petros P.; LASKARI, Katerina; TEKTONIDOU, Maria; CICCIA, Francesco; IACONO, Daniela; RICCIO, Flavia; RAGAB, Gaafar; HUSSEIN, Mohamed A.; GOVONI, Marcello; RUFFILLI, Francesca; DIRESKENELI, Haner; ALIBAZ-ONER, Fatma; GIACOMELLI, Roberto; NAVARINI, Luca; BARTOLONI, Elena; RICCUCCI, Ilenia; MARTIN-NARES, Eduardo; TORRES-RUIZ, Jiram; CIPRIANI, Paola; COLA, Ilenia Di; HERNANDEZ-RODRIGUEZ, Jose; GOMEZ-CAVERZASCHI, Veronica; DAGNA, Lorenzo; TOMELLERI, Alessandro; MAKOWSKA, Joanna; BRZEZINSKA, Olga; IAGNOCCO, Annamaria; BELLIS, Elisa; CAGGIANO, Valeria; GAGGIANO, Carla; TARSIA, Maria; MORMILE, Ilaria; EMMI, Giacomo; SFRISO, Paolo; MONTI, Sara; ERTEN, Suekran; GIUDICE, Emanuela Del; LUBRANO, Riccardo; CONTI, Giovanni; OLIVIERI, Alma Nunzia; GULLO, Alberto Lo; THARWAT, Samar; KARAMANAKOS, Anastasios; GIDARO, Antonio; MAGGIO, Maria Cristina; TORRE, Francesco La; CARDINALE, Fabio; OGUNJIMI, Benson; MAIER, Armin; SEBASTIANI, Gian Domenico; OPRIS-BELINSKI, Daniela; FRASSI, Micol; VIAPIANA, Ombretta; BIZZI, Emanuele; CARUBBI, Francesco; FOTIS, Lampros; TUFAN, Abdurrahman; KARDAS, Riza Can; WIESIK-SZEWCZYK, Ewa; JAHNZ-ROZYK, Karina; FABIANI, Claudia; FREDIANI, Bruno; BALISTRERI, Alberto; RIGANTE, Donato; CANTARINI, Luca
    Objectives: To describe clinical characteristics of patients with Still's disease treated with methotrexate (MTX) and to assess drug effectiveness evaluating change in disease activity, reduction of inflammatory markers, and glucocorticoid (GC)-sparing effect. Methods: Patients with Still's disease treated with MTX were assessed among those included in AIDA Network Still Disease Registry.Results: In this registry, 171 patients with Still's disease were treated with MTX (males 43.3%, age 37.1 & PLUSMN; 16.0 years). They were mainly characterised by joint features and fever without a prominent multiorgan involvement. MTX was administered with GCs in 68.4% of patients, with other conventional synthetic DMARDs in 6.4%, and with biologic DMARDs in 25.1%. A significant reduction of the modified systemic score was observed, and 38.6% patients were codified as being in clinical remission at the end of follow-up. The concomitant administration of a biologic DMARD resulted a predictor of the clinical remission. Furthermore, a reduction of inflammatory markers and ferritin levels was observed following the administration of MTX. Additionally, a marked reduction of the dosage of concomitant GCs was identified, while 36.7% discontinued such drugs. Male gender appeared as a predictor of GC discontinuation. MTX was discontinued in 12.3% of patients because of adverse effects, and in 12.3% for lack of efficacy.Conclusions: Clinical characteristics of patients with Still's disease treated with MTX were described, mainly joint features and fever without a prominent multiorgan involvement. The clinical usefulness of MTX was reported in reducing the disease activity, decreasing the inflammatory markers, and as GC-sparing agent.
  • conferenceObject
    ASSOCIATION BETWEEN OSTEOPROTEGERIN AND RANKLSINGLE NUCLEOTIDE POLYMORPHISMS AND DESTRUCTIVE RHINOSINUSITIS IN PATIENTS WITH GRANULOMATOSIS WITH POLYANGIIITIS
    (2023) FURQUIM, Marilia; HOUNPKE, Bidossessi; CAPARBO, Valeria; GIARDINI, Henrique; BARBAS, Carmen; DOMICIANO, Diogo; SHINJO, Samuel; PEREIRA, Rosa
  • article 0 Citação(ões) na Scopus
    Adult-onset Still's disease with ankylosis of the distal interphalangeal joints: beyond psoriatic arthritis
    (2023) CORDEIRO, R. A.; ANTONELLI, I. P. B.; GIARDINI, H. A. M.
  • article 2 Citação(ões) na Scopus
    Still's disease continuum from childhood to elderly: data from the international AIDA Network Still's disease registry
    (2023) VITALE, Antonio; CAGGIANO, Valeria; LOPALCO, Giuseppe; GIARDINI, Henrique A. Mayrink; CICCIA, Francesco; ALMAGHLOUTH, Ibrahim A.; RUSCITTI, Piero; SFIKAKIS, Petros P.; TUFAN, Abdurrahman; DAGNA, Lorenzo; GIACOMELLI, Roberto; HINOJOSA-AZAOLA, Andrea; RAGAB, Gafaar; DIRESKENELI, Haner; FOTIS, Lampros; SOTA, Jurgen; IANNONE, Florenzo; MORRONE, Maria; ANTONELLI, Isabele Parente de Brito; DAGOSTIN, Marilia Ambiel; IACONO, Daniela; PATRONE, Martina; ASFINA, Kazi; ALANAZI, Fehaid; COLA, Ilenia Di; GAGGIANO, Carla; TEKTONIDOU, Maria G.; KARDAS, Riza Can; KUCUK, Hamit; CAMPOCHIARO, Corrado; TOMELLERI, Alessandro; NAVARINI, Luca; BERARDICURTI, Onorina; MARTIN-NARES, Eduardo; TORRES-RUIZ, Jiram; MAHMOUD, Ayman Abdel-Monem Ahmed; ALIBAZ-ONER, Fatma; KOURTESI, Katerina; TARSIA, Maria; SFRISO, Paolo; MAKOWSKA, Joanna; GOVONI, Marcello; TORRE, Francesco La; MAGGIO, Maria Cristina; MONTI, Sara; GIUDICE, Emanuela Del; EMMI, Giacomo; BARTOLONI, Elena; HERNANDEZ-RODRIGUEZ, Jose; GOMEZ-CAVERZASCHI, Veronica; MAIER, Armin; SIMONINI, Gabriele; IAGNOCCO, Annamaria; CONTI, Giovanni; OLIVIERI, Alma Nunzia; PAULIS, Amato De; GULLO, Alberto Lo; VIAPIANA, Ombretta; WIESIK-SZEWCZYK, Ewa; ERTEN, Sukran; OGUNJIMI, Benson; CARUBBI, Francesco; THARWAT, Samar; LASKARI, Katerina; COSTI, Stefania; TRIGGIANESE, Paola; KARAMANAKOS, Anastasios; CONFORTI, Alessandro; FRASSI, Micol; SEBASTIANI, Gian Domenico; GIDARO, Antonio; MAURO, Angela; BALISTRERI, Alberto; FABIANI, Claudia; FREDIANI, Bruno; CANTARINI, Luca
    Objective Still's disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still's disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still's disease. Methods Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still's disease. Results A total of 411 patients suffering from Still's disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still's disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p<0.0001) were significantly more frequent among elderly-onset patients compared with paediatric-onset subjects. Regarding laboratory data, thrombocytosis was significantly more frequent among paediatric patients onset compared with adult-onset subjects (p<0.0001), while thrombocytopenia was more frequent among elderly-onset patients although statistical significance was only bordered. No substantial differences were observed in the response to treatments. Conclusions Despite some minor difference between groups, overall, demographic, clinical, laboratory and treatments aspects of Still's disease were similarly observed in patients at all ages. This supports that pediatric-onset, adult-onset and elderly-onset Still's disease is the same clinical condition arising in different ages.
  • article 2 Citação(ões) na Scopus
    Musculoskeletal manifestations in children with Behcet's syndrome: data from the AIDA Network Behcet's Syndrome Registry
    (2023) GAGGIANO, Carla; MASELLI, Anna; SFIKAKIS, Petros P.; LASKARI, Katerina; RAGAB, Gaafar; HEGAZY, Mohamed Tharwat; LAYMOUNA, Ahmed Hatem; LOPALCO, Giuseppe; ALMAGHLOUTH, Ibrahim A.; ASFINA, Kazi Nur; ALAHMED, Ohoud; MAYRINK, Henrique Ayres Giardini; ANTONELLI, Isabele Parente de Brito; CATTALINI, Marco; PIGA, Matteo; SOTA, Jurgen; GENTILESCHI, Stefano; MAGGIO, Maria Cristina; OPRIS-BELINSKI, Daniela; HATEMI, Gulen; INSALACO, Antonella; OLIVIERI, Alma Nunzia; TUFAN, Abdurrahman; KARADENIZ, Hazan; KARDAS, Riza Can; TORRE, Francesco La; CARDINALE, Fabio; MARINO, Achille; GUERRIERO, Silvana; RUSCITTI, Piero; TARSIA, Maria; VITALE, Antonio; CAGGIANO, Valeria; TELESCA, Salvatore; IANNONE, Florenzo; PARRETTI, Veronica; FRASSI, Micol; ARAGONA, Emma; CICCIA, Francesco; WIESIK-SZEWCZYK, Ewa; IONESCU, Ruxandra; SAHIN, Ali; AKKOC, Nurullah; HINOJOSA-AZAOLA, Andrea; THARWAT, Samar; HERNANDEZ-RODRIGUEZ, Jose; ESPINOSA, Gerard; CONTI, Giovanni; GIUDICE, Emanuela Del; GOVONI, Marcello; EMMI, Giacomo; FABIANI, Claudia; BALISTRERI, Alberto; FREDIANI, Bruno; RIGANTE, Donato; CANTARINI, Luca
    This study aims to describe musculoskeletal manifestations (MSM) in children with Behcet's syndrome (BS), their association with other disease manifestations, response to therapy, and long-term prognosis. Data were retrieved from the AIDA Network Behcet's Syndrome Registry. Out of a total of 141 patients with juvenile BS, 37 had MSM at disease onset (26.2%). The median age at onset was 10.0 years (IQR 7.7). The median follow-up duration was 21.8 years (IQR 23.3). Recurrent oral (100%) and genital ulcers (67.6%) and pseudofolliculitis (56.8%) were the most common symptoms associated with MSM. At disease onset, 31 subjects had arthritis (83.8%), 33 arthralgia (89.2%), and 14 myalgia (37.8%). Arthritis was monoarticular in 9/31 cases (29%), oligoarticular in 10 (32.3%), polyarticular in 5 (16.1%), axial in 7 (22.6%). Over time, arthritis became chronic-recurrent in 67.7% of cases and 7/31 patients had joint erosions (22.6%). The median Behcet's Syndrome Overall Damage Index was 0 (range 0-4). Colchicine was inefficacious for MSM in 4/14 cases (28.6%), independently from the type of MSM (p = 0.46) or the concomitant therapy (p = 0.30 for cDMARDs, p = 1.00 for glucocorticoids); cDMARDs and bDMARDs were inefficacious for MSM in 6/19 (31.4%) and 5/12 (41.7%) cases. The presence of myalgia was associated with bDMARDs inefficacy (p = 0.014). To conclude, MSM in children with BS are frequently associated with recurrent ulcers and pseudofolliculitis. Arthritis is mostly mono- or oligoarticular, but sacroiliitis is not unusual. Prognosis of this subset of BS is overall favorable, though the presence of myalgia negatively affects response to biologic therapies. ClinicalTrials.gov Identifier: NCT05200715 (registered on December 18, 2021).
  • article 0 Citação(ões) na Scopus
    Clinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry
    (2023) TRIGGIANESE, Paola; VITALE, Antonio; LOPALCO, Giuseppe; GIARDINI, Henrique Ayres Mayrink; CICCIA, Francesco; AL-MAGHLOUTH, Ibrahim; RUSCITTI, Piero; SFIKAKIS, Petros Paul; IANNONE, Florenzo; ANTONELLI, Isabele Parente de Brito; PATRONE, Martina; ASFINA, Kazi Nur; COLA, Ilenia Di; LASKARI, Katerina; GAGGIANO, Carla; TUFAN, Abdurrahman; SFRISO, Paolo; DAGNA, Lorenzo; GIACOMELLI, Roberto; HINOJOSA-AZAOLA, Andrea; RAGAB, Gaafar; FOTIS, Lampros; DIRESKENELI, Haner; SPEDICATO, Veronica; DAGOSTIN, Marilia Ambiel; IACONO, Daniela; ALI, Hebatallah Hamed; CIPRIANI, Paola; SOTA, Jurgen; KARDAS, Riza Can; BINDOLI, Sara; CAMPOCHIARO, Corrado; NAVARINI, Luca; GENTILESCHI, Stefano; MARTIN-NARES, Eduardo; TORRES-RUIZ, Jiram; SAAD, Moustafa Ali; KOURTESI, Katerina; ALIBAZ-ONER, Fatma; SEVIK, Gizem; IAGNOCCO, Annamaria; MAKOWSKA, Joanna; GOVONI, Marcello; MONTI, Sara; MAGGIO, Maria Cristina; TORRE, Francesco La; GIUDICE, Emanuela Del; HERNANDEZ-RODRIGUEZ, Jose; BARTOLONI, Elena; EMMI, Giacomo; CHIMENTI, Maria Sole; MAIER, Armin; SIMONINI, Gabriele; CONTI, Giovanni; OLIVIERI, Alma Nunzia; TARSIA, Maria; PAULIS, Amato De; GULLO, Alberto Lo; WIESIK-SZEWCZYK, Ewa; VIAPIANA, Ombretta; OGUNJIMI, Benson; THARWAT, Samar; ERTEN, Sukran; NUZZOLESE, Rossana; KARAMANAKOS, Anastasios; FRASSI, Micol; CONFORTI, Alessandro; CAGGIANO, Valeria; MARINO, Achille; SEBASTIANI, Gian Domenico; GIDARO, Antonio; TOMBETTI, Enrico; CARUBBI, Francesco; RUBEGNI, Giovanni; CARTOCCI, Alessandra; BALISTRERI, Alberto; FABIANI, Claudia; FREDIANI, Bruno; CANTARINI, Luca
    To characterize clinical and laboratory signs of patients with Still's disease experiencing macrophage activation syndrome (MAS) and identify factors associated with MAS development. Patients with Still's disease classified according to internationally accepted criteria were enrolled in the AutoInflammatory Disease Alliance (AIDA) Still's Disease Registry. Clinical and laboratory features observed during the inflammatory attack complicated by MAS were included in univariate and multivariate logistic regression analysis to identify factors associated to MAS development. A total of 414 patients with Still's disease were included; 39 (9.4%) of them developed MAS during clinical history. At univariate analyses, the following variables were significantly associated with MAS: classification of arthritis based on the number of joints involved (p = 0.003), liver involvement (p = 0.04), hepatomegaly (p = 0.02), hepatic failure (p = 0.01), axillary lymphadenopathy (p = 0.04), pneumonia (p = 0.03), acute respiratory distress syndrome (p < 0.001), platelet abnormalities (p < 0.001), high serum ferritin levels (p = 0.009), abnormal liver function tests (p = 0.009), hypoalbuminemia (p = 0.002), increased LDH (p = 0.001), and LDH serum levels (p < 0.001). At multivariate analysis, hepatomegaly (OR 8.7, 95% CI 1.9-52.6, p = 0.007) and monoarthritis (OR 15.8, 95% CI 2.9-97.1, p = 0.001), were directly associated with MAS, while the decade of life at Still's disease onset (OR 0.6, 95% CI 0.4-0.9, p = 0.045), a normal platelet count (OR 0.1, 95% CI 0.01-0.8, p = 0.034) or thrombocytosis (OR 0.01, 95% CI 0.0-0.2, p = 0.008) resulted to be protective. Clinical and laboratory factors associated with MAS development have been identified in a large cohort of patients based on real-life data.