ANDRE BROOKING NEGRAO
Projetos de Pesquisa
Unidades Organizacionais
IPER, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
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- Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study(2015) SCHANTZ, Malcolm von; TAPOROSKI, Tamara P.; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; VALLADA, Homero; KRIEGER, Jose E.; PEDRAZZOLI, Mario; NEGRAO, Andre B.; PEREIRA, Alexandre C.Diurnal preference (chronotype) is a useful instrument for studying circadian biology in humans. It harbours trait-like dimensions relating to circadian period and sleep homeostasis, but also has ontogenetic components (morningness increases with age). We used the Morningness-Eveningness questionnaire (MEQ) in the Baependi study, a family-based cohort study based in a small town in Minas Gerais, Brazil. The population is highly admixed and has a cohesive and conservative lifestyle. 825 individuals (497 female) aged 18-89 years (average +/- SD = 46.4 +/- 16.3) and belonging to 112 different families participated in this study. The average MEQ score was 63.5 +/- 11.2 with a significant (P < 0.0001) linear increase with age. Morningness was significantly (P, 0.0001) higher in the rural (70.2 +/- 9.8) than in the municipal zone (62.6 +/- 11.1), and was also significantly (P = 0.025) higher in male (64.6 +/- 10.9) than in female (62.8 +/- 11.2) participants. Thus, in spite of universal access to electricity, the Baependi population was strongly shifted towards morningness, particularly in the rural zone. Heritability of MEQ score was 0.48 when adjusted for sex and age, or 0.38 when adjusted for sex, age, and residential zone. The reported MEQ score heritability is more akin to those of previous twin studies than previous family studies.
- Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study(2015) TAPOROSKI, Tamara P.; NEGRAO, Andre B.; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; ALVIM, Rafael O.; OLIVEIRA, Camila M. de; KRIEGER, Jose E.; SCHANTZ, Malcolm von; VALLADA, Homero; PEREIRA, Alexandre C.To investigate the phenotypic and genetic overlap between anxiety and depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited from a cohort of 93 families (mean age +/- SD 42 +/- 16.3, 57% female) in the rural town of Baependi, Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to assess depression and anxiety symptoms. Heritability estimates were obtained by an adjusted variance component model. Bivariate analyses were performed to obtain the partition of the covariance of anxiety and depression into genetic and environmental components, and to calculate the genetic contribution modulating both sets of symptoms. Anxiety and depression scores were 7.49 +/- 4.01 and 5.70 +/- 3.82, respectively. Mean scores were affected by age and were significantly higher in women. Heritability for depression and anxiety, corrected for age and sex, were 0.30 and 0.32, respectively. Significant genetic correlations (p(g) = 0.81) were found between anxiety and depression scores; thus, nearly 66% of the total genetic variance in one set of symptoms was shared with the other set. Our results provided strong evidence for a genetic overlap between anxiety and depression symptoms, which has relevance for our understanding of the biological basis of these constructs and could be exploited in genome-wide association studies.
- Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study(2015) SCHANTZ, M. Von; TAPOROSKI, T.; HORIMOTO, A.; ESTEBAN, N.; VALLADA, H.; KRIEGER, J.; PEDRAZZOLI, M.; NEGRAO, A.; PEREIRA, A.