ANDRE BROOKING NEGRAO
Projetos de Pesquisa
Unidades Organizacionais
IPER, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
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Resultados de Busca
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- Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study(2015) SCHANTZ, Malcolm von; TAPOROSKI, Tamara P.; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; VALLADA, Homero; KRIEGER, Jose E.; PEDRAZZOLI, Mario; NEGRAO, Andre B.; PEREIRA, Alexandre C.Diurnal preference (chronotype) is a useful instrument for studying circadian biology in humans. It harbours trait-like dimensions relating to circadian period and sleep homeostasis, but also has ontogenetic components (morningness increases with age). We used the Morningness-Eveningness questionnaire (MEQ) in the Baependi study, a family-based cohort study based in a small town in Minas Gerais, Brazil. The population is highly admixed and has a cohesive and conservative lifestyle. 825 individuals (497 female) aged 18-89 years (average +/- SD = 46.4 +/- 16.3) and belonging to 112 different families participated in this study. The average MEQ score was 63.5 +/- 11.2 with a significant (P < 0.0001) linear increase with age. Morningness was significantly (P, 0.0001) higher in the rural (70.2 +/- 9.8) than in the municipal zone (62.6 +/- 11.1), and was also significantly (P = 0.025) higher in male (64.6 +/- 10.9) than in female (62.8 +/- 11.2) participants. Thus, in spite of universal access to electricity, the Baependi population was strongly shifted towards morningness, particularly in the rural zone. Heritability of MEQ score was 0.48 when adjusted for sex and age, or 0.38 when adjusted for sex, age, and residential zone. The reported MEQ score heritability is more akin to those of previous twin studies than previous family studies.
- Metabolic syndrome alters relationships between cardiometabolic variables, cognition and white matter hyperintensity load(2019) ALKAN, E.; TAPOROSKI, T. P.; STERR, A.; SCHANTZ, M. von; VALLADA, H.; KRIEGER, J. E.; PEREIRA, A. C.; ALVIM, R.; HORIMOTO, A. R. V. R.; POMPEIA, S.; NEGRAO, A. B.; EVANS, S. L. H.Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, WMH load and cognitive performance are uncertain. We investigated these in a Brazilian sample (aged 50-85) with (N = 61) and without (N=103) MetS. Stepwise regression models identified effects of cardiometabolic and demographic variables on WMH load (from FLAIR MRI) and verbal recall performance. WMH volume was greater in MetS, but verbal recall performance was not impaired. Age showed the strongest relationship with WMH load. Across all participants, systolic blood pressure (SBP) and fasting blood glucose were also contributors, and WMH volume was negatively associated with verbal recall performance. In non-MetS, higher HbA1c, SBP, and number of MetS components were linked to poorer recall performance while higher triglyceride levels appeared to be protective. In MetS only, these relationships were absent but education exerted a strongly protective effect on recall performance. Thus, results support MetS as a construct: the clustering of cardiometabolic variables in MetS alters their individual relationships with cognition; instead, MetS is characterised by a greater reliance on cognitive reserve mechanisms. In non-MetS, strategies to control HbA1c and SBP should be prioritised as these have the largest impact on cognition.
- Timing and quality of sleep in a rural Brazilian family-based cohort, the Baependi Heart Study(2016) BEIJAMINI, F.; KNUTSON, K. L.; LORENZI-FILHO, G.; EGAN, K. J.; TAPOROSKI, T. P.; PAULA, L. K. G. De; NEGRAO, A. B.; HORIMOTO, A. R. V. R.; DUARTE, N. E.; VALLADA, H.; KRIEGER, J. E.; PEDRAZZOLI, M.; PEREIRA, A. C.; SCHANTZ, M. vonSleep is modulated by several factors, including sex, age, and chronotype. It has been hypothesised that contemporary urban populations are under pressure towards shorter sleep duration and poorer sleep quality. Baependi is a small town in Brazil that provides a window of opportunity to study the influence of sleep patterns in a highly admixed rural population with a conservative lifestyle. We evaluated sleep characteristics, excessive daytime sleepiness, and chronotype using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Morningness-Eveningness Questionnaire questionnaires, respectively. The sample consisted of 1,334 subjects from the Baependi Heart study (41.5% male; age: 46.5 +/- 16.2 y, range: 18-89 years). Average self-reported sleep duration was 07:07 +/- 01:31 (bedtime 22:32 +/- 01:27, wake up time: 06:17 +/- 01:25 hh:min), sleep quality score was 4.9 + 3.2, chronotype was 63.6 +/- 10.8 and daytime sleepiness was 7.4 +/- 4.8. Despite a shift towards morningness in the population, chronotype remained associated with reported actual sleep timing. Age and sex modulated the ontogeny of sleep and chronotype, increasing age was associated with earlier sleep time and shorter sleep duration. Women slept longer and later, and reported poorer sleep quality than men (p < 0.0001). This study provides indirect evidence in support of the hypothesis that sleep timing was earlier prior to full urbanisation.