FABIO LUIS DE SOUZA DURAN
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
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- Gray Matter, Lateral Ventricle Volumes, and Executive Functioning in Cannabis Users with First-Episode Psychosis(2017) CUNHA, P. J.; ROSA, P. G. P.; DURAN, F. L. S.; SANTOS, L. C.; CRIPPA, J. A. S.; BUSATTO, G. F.; SCHAUFELBERGER, M. S.This chapter is focused on examining the brain structural and executive alterations associated with cannabis use in patients with first-episode psychosis (FEP). Cannabis users with FEP are more likely to present a relatively ""preserved"" brain, and less executive deficits, at least in the beginning of their disorder. Initial neurostructural alterations will depend on the level of the patient's premorbid functioning, among other factors. As the cannabis use progress, the patient will present a pattern characterized by cognitive impairments and brain structural abnormalities, such as executive dysfunction, gray matter reductions, and lateral ventricle enlargements. In clinical practice, it would be relevant to develop strategies aiming to prevent cannabis use among adolescents, especially those with prodromal symptoms, and with a family history of psychosis. Early focused interventions for patients with FEP could also help to prevent relapse on cannabis use for a better prognosis. © 2017 Elsevier Inc. All rights reserved.