LEA CAMPOS DE OLIVEIRA

(Fonte: Lattes)
Índice h a partir de 2011
14
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Unidades Organizacionais
LIM/46 - Laboratório de Parasitologia Médica, Hospital das Clínicas, Faculdade de Medicina
LIM/03 - Laboratório de Medicina Laboratorial, Hospital das Clínicas, Faculdade de Medicina

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  • conferenceObject
    GALECTIN 3 IS ASSOCIATED WITH THE MORE SEVERE FORM OF CHAGAS CARDIOMYOPATHY
    (2015) FERNANDES, Fabio; MOREIRA, Carlos H.; OLIVEIRA, Lea C.; SOUZA, Marcela; MADY, Charles; IANNI, Barbara M.; MANULI, Erika; SABINO, Ester C.
  • conferenceObject
    BENZNIDAZOLE-RELATED ADVERSE DRUG REACTIONS IN BRAZILIAN PATIENTS WITH CHAGAS DISEASE
    (2015) MOREIRA, Carlos H.; CARVALHO, Noemia B.; FERRUFINO, Rosario Q.; GUASTINI, Cristina M.; LINDOSO, Jose Angelo L.; OLIVEIRA, Lea C.; MANULI, Erika R.; SOUZA, Marcela; SABINO, Ester C.
  • article 7 Citação(ões) na Scopus
    Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes
    (2015) OLIVEIRA, Lea Campos de; GOLDBERG, Anna Carla; MARIN, Maria Lucia Carnevale; SCHNEIDWIND, Karina Rosa; FRADE, Amanda Farage; KALIL, Jorge; MIURA, Irene Kasue; PUGLIESE, Renata Pereira Sustovich; DANESI, Vera Lucia Baggio; PORTA, Gilda
    Pediatric autoimmune hepatitis (AIH) patients present hypergammaglobulinemia, periportal CD8(+) cytotoxic T cell infiltration, and cirrhosis. Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1. We previously detected increased IgE serum levels and sought to compare clinical and histological features according to IgE levels in AIH (n = 74, ages 1-14 years) patients. Additionally, we typed 117 patients and 227 controls for functional polymorphisms of IL4, IL13, IL5, and IL4RA genes involved in IgE switching and eosinophil maturation that might contribute to overall genetic susceptibility to AIH. Serum IgE levels were high in 55% of AIH-1, but only in 12% of AIH-2 (P = 0.003) patients. Liver IgE was present in 91.3% of AIH-1 patients. The A alleles at both IL13 rs20541 and IL4RA rs1805011 were associated with AIH-1 (P = 0.024, OR = 1.55 and P < 0.0001, OR = 2.15, resp.). Furthermore, individuals presenting homozygosis for the A allele at IL4RA rs1805011 and HLA-DRB1*03 and/or *13 allele had sixfold greater risk to develop the disease (OR = 14.00, P < 0.001). The novel association suggests an additional role for IgE-linked immune response genes in the pathogenesis of AIH.