ROSSANA VERONICA MENDOZA LOPEZ
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
6 resultados
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- Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series(2019) PIMENTEL, D. R. Neto; NUNES, E. Montosa; TERMINI, L.; NUNES, R. Almeida Lima; LOPEZ, R. V. Mendoza; FERREIRA, S.; BOCCARDO, E.; PRADO, J. C. Mann; ENOKIHARA, M. M. S. S.; SICHERO, L.; TOMIMORI, J.
- Genetic variants of HPV-16 and their geographical and anatomical distribution in men: A systematic review with meta-analysis(2021) FERREIRA, Matthew Thomas; GONCALVES, Milena Giulia; LOPEZ, Rossana Veronica Mendoza; SICHERO, LauraBackground: The prevalence of Human Papillomavirus type 16 (HPV-16) variants in men and the association with tumor development has not been fully investigated. We estimated the prevalence of genital, anal, and oral HPV16 infections in men through a systematic review and meta-analysis. Methods: Seven databases were searched and included studies that identified HPV-16 positive males, HPV-16 variants (lineages/sublineages), and indicated the sample?s anatomical origin. This protocol is registered in PROSPERO (CRD42020178013). Results: The database searches yielded 14 studies including 445 HPV-16 positive samples classified as lineage A (n = 390), lineage D (n = 43), lineage B (n = 10), and lineage C (n = 2) variants. Lineage A variants predominated among the anatomical sites and the diverse geographical regions. Conclusions: HPV-16 lineages vary according to anatomical and geographical region. According to this preliminary evaluation of the current literature, we hypothesize that, similar to women, specific HPV-16 variants may also be associated to increased cancer risk in men.
Prevalence and persistence of HPV-16 molecular variants in the anal canal of men: The HIM study
(2022) GONCALVES, Milena Giulia; FERREIRA, Matthew Thomas; LOPEZ, Rossana Veronica Mendoza; FERREIRA, Silvaneide; SIRAK, Bradley; BAGGIO, Maria Luiza; LAZCANO-PONCE, Eduardo; NYITRAY, Alan G.; GIULIANO, Anna R.; VILLA, Luisa L.; SICHERO, LauraBackground: HPV-16 causes approximately 90% of anal canal (AC) cancers worldwide. This study aimed to evaluate the prevalence and persistence of HPV-16 genetic variants in the AC of men from three different countries (Brazil, Mexico and United States) and to further identify sociodemographic and behavioral factors associated with these infections.& nbsp;Methods: Participants from the multinational prospective HPV Infection in Men (HIM) Study who had at least one HPV-16 positive AC swab were included. Characterization into HPV-16 genetic variants was successfully performed by PCR-sequencing in 95.6% (217/227) samples and these were classified into HPV-16 lineages and sublineages.& nbsp;Results: We observed higher prevalence of lineage A variants, mainly from A1 sublineage, in all countries. Non-A lineage variants were mostly detected in men from Brazil, where higher diversity of sublineage variants was detected during follow-up. Compare to men detected with Non-A HPV-16 lineage variants, men infected with lineage A reported a higher lifetime number of female sexual partners. Finally, a significantly higher prevalence of Non-A lineage variants was observed among men who have sex with men (MSM) with a transient HPV-16 AC infection (p = 0.033), but no significant differences regarding variants lineages and persistence status were observed when stratified by country, self-reported ethnicity or age.& nbsp;Conclusions: Our data extend previous reports which indicate that globally HPV-16 variants are unevenly distributed, and contribute further to studies of the natural history of AC HPV infections in men.- Prevalence of human papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis(2021) SICHERO, Laura; FERREIRA, Silvaneide; LOPEZ, Rossana V. M.; MELLO, Barbara P.; COSTA, Victor; EL-ACHKAR, Vivian N. R.; CARLOS, Roman; RIBEIRO-SILVA, Alfredo; PIGNATARI, Shirley; KAMINAGAKURA, Estela; VILLA, Luisa L.Human papillomavirus (HPV) types 6 and 11 are the etiological agents of recurrent respiratory papillomatosis (RRP). We examined the prevalence and distribution of HPVs 6 and 11 genetic variants in juvenile onset (JORRP) and adult onset (AORRP) laryngeal papillomas. Cases of JORRP and AORRP were collected, retrospectively. HPV detection and genotyping were accessed by polymerase chain reaction-sequencing in 67 RRP samples. Overall, the most prevalent HPV-6 variants were from B1 (55.8%) and B3 (27.9%) sublineages, whereas among HPV-11 positive samples A2 (62.5%) variants were predominant. A higher prevalence of HPV-6 B1 was observed in JORRP (83.3% B1 and 16.7% B3), compared with AORRP cases (58.3% B1 and 41.7% B3). HPV-11 A2 variants were more prevalent both in JORRP (57.2%) and in AORRP cases (70.0%). Nevertheless, with the exception that HPV-6 B1 were significantly less likely to recur, there was a lack of association between any particular HPVs 6 or 11 variant and clinicopathological features. Our data do not support an association between HPVs 6 and 11 variability and RRP.
article 13 Citação(ões) na Scopus Concordance of Beta-papillomavirus across anogenital and oral anatomic sites of men: The HIM Study(2017) NUNES, Emily M.; LOPEZ, Rossana V. M.; SUDENGA, Staci L.; GHEIT, Tarik; TOMMASINO, Massimo; BAGGIO, Maria L.; FERREIRA, Silvaneide; GALAN, Lenice; SILVA, Roberto C.; LAZCANO-PONCE, Eduardo; GIULIANO, Anna R.; VILLA, Luisa L.; SICHERO, LauraWe evaluated the concordance between beta-HPVs detected in external genital skin, anal canal, and oral cavity specimens collected simultaneously from 717 men that were participating in the multinational HIM Study. Viral genotyping was performed using the Luminex technology. Species- and type-specific concordance was measured using kappa statistics for agreement. Overall, concordance of P-HPVs across sites was low and mainly observed among paired genital/anal canal samples. When grouped by species, solely beta-4 HPVs showed moderate concordance in genital/anal pairs (k = 0.457), which could be attributed to the substantial concordance of HPV-92 in men from Brazil and Mexico (k > 0.610). beta-HPV type concordance was higher in Mexico, where HPV-19 was consistently concordant in all anatomic site combinations. Our analysis indicates that type-specific concordance across sites is limited to few viral types; however, these infections seem to occur more often than would be expected by chance, suggesting that although rare, there is agreement among sites.- Human Papillomavirus 16 Lineage A Variants Associated With Persistent Genital Infections in Men: The HPV Infection in Men (HIM) Study(2023) FERREIRA, Matthew Thomas; LOPEZ, Rossana Veronica Mendoza; GONCALVES, Milena Giulia; FERREIRA, Silvaneide; SIRAK, Bradley; BAGGIO, Maria Luizai; LAZCANO-PONCE, Eduardo; NYITRAY, Alan G.; GIULIANO, Anna R.; VILLA, Luisa L.; SICHERO, Laura; LIN, Huiyi; MESSINA, Jane; CAMPBELL, Christine Pierce; GAGE, Christine; INGLES, Donna J.; ISAACS, Kim; KENNEDY, Kayoko; BOBANIC, Andrea; RAHMAN, Shams; SCHABATH, Matthew; NYITRAY, Alan; RATHWELL, Julie; PAULA, Lenice Galan de; CINTRA, Ricardo; CERNICCHIARO, Filomena; RIBEIRO, Graca; OTERO, Rosaria; BOCALON, Roberta; ANTUNES, Juliana; SILVA, Fernanda; TERRERI, Rossana; VALDEZ, Aurelio Cruz; VASQUEZ, Rene de Jesus Alvear; JUAREZ, Oscar Rojas; SOSA, Rossana del Carmen Gonzalez; VENCES, Rosangel Rios; SEGURA, Martha Huerta; GALVAN, Alicia Rodriguez; RODRIGUEZ, Paula Roman; VELEZ, Ana Laura Landa; GARCIA, Griselda Diaz; ABARCA, Veronica Chavez; QUEVEDO, Gisela Flores; NEVAREZ, Maria del Pilar Hernandez; MARTINEZ, Guillermina Sanchez; ROJAS, Adriana Ortiz; FLORES, Carlos Omar Barrera; MANGONE, Flavia Rotea; PAVANELLI, Ana CarolinaWe show for the first time the influence of human papillomavirus (HPV) 16 nucleotide variability on the risk of persistent infection in the male genitalia. Our data suggest differences in the natural history of HPV-16 variants between men and women. Background Human papillomavirus (HPV) 16 non-A lineage variants have higher carcinogenic potential for cervical cancer. HPV-16 variants natural history among males is not established. We evaluated HPV-16 variants prevalence and persistence in the external genitalia of men enrolled in the prospective HPV Infection in Men (HIM) Study. Methods The HIM Study included men from the United States, Brazil, and Mexico. HPV-16 variants were distinguished using polymerase chain reaction sequencing. The prevalence of HPV-16 variants was assessed, and associations with infection persistence were estimated. Results We characterized the HPV-16 variants for 1700 genital swab samples from 753 men and 22 external genital lesions in 17 men. The prevalence of HPV-16 lineages differed by country and marital status (P < .001). Overall, 90.9% of participants harbored lineage A variants. The prevalence of non-A lineages was heterogenous among countries. HPV-16 lineage A variants were associated with a 2.69-fold increased risk of long-term persistent infections compared with non-A lineages. All high-grade penile intraepithelial neoplasia harbored lineage A variants and occurred in the context of long-term persistent infections with the same variants. Conclusions The prevalence and persistence of HPV-16 variants observed at the male external genitalia suggest differences in the natural history of these variants between men and women, which may be associated with intrinsic differences in the infected genital epithelia.