JOSE EDUARDO KRIEGER

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Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder

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Autor: KRIEGER, Jose Eduardo × search.filters.applied.f.dateIssued: 2021 × Tipo de acesso: openAccess ×

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  • article 15 Citação(ões) na Scopus
    Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix
    (2021) RIBEIRO-SILVA, Joao Carlos; NOLASCO, Patricia; KRIEGER, Jose Eduardo; MIYAKAWA, Ayumi Aurea
    Vascular aging is accompanied by the fragmentation of elastic fibers and collagen deposition, leading to reduced distensibility and increased vascular stiffness. A rigid artery facilitates elastin to degradation by MMPs, exposing vascular cells to greater mechanical stress and triggering signaling mechanisms that only exacerbate aging, creating a self-sustaining inflammatory environment that also promotes vascular calcification. In this review, we highlight the role of crosstalk between smooth muscle cells and the vascular extracellular matrix (ECM) and how aging promotes smooth muscle cell phenotypes that ultimately lead to mechanical impairment of aging arteries. Understanding the underlying mechanisms and the role of associated changes in ECM during aging may contribute to new approaches to prevent or delay arterial aging and the onset of cardiovascular diseases.