JOSE EDUARDO KRIEGER

(Fonte: Lattes)
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Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder

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Agora exibindo 1 - 10 de 54
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    PREDICTORS OF CORONARY ARTERY CALCIFICATION INCIDENCE IN SEVERE HYPERCHOLESTEROLEMIA
    (2023) MARTE, Ana; MINAME, Marcio Hiroshi; PARDI, Estevao Magalhaes; GANEM, Lucas; MIZUTA, Marjorie Hayashida; ROCHA, Viviane Zorzanelli; PEREIRA, Alexandre Costa; KRIEGER, Jose Eduardo; SANTOS, Raul
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    Common Molecular Signature for Human Endothelial Dysfunction Associated With Abnormalities in Blood Flow, Lipids, Inflammation and Hypoxia
    (2019) SOUSA, Iguaracy P.; SOUZA, Vinicius de; TEIXEIRA, Samantha K.; KRIEGER, Jose E.
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    Influence of genetic polymorphisms of alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin receptor B2 on treadmill exercise test responses
    (2012) NUNES, R. A. Belo; BARROSO, L. P.; SCHMIDT, R. T.; BARRETO, D. D.; FREITAS, H. F.; PEREIRA, A. C.; KRIEGER, J. E.; MANSUR, A. J.
    Purpose: Treadmill exercise testing responses have been associated with cardiovascular prognosis in individuals without overt heart disease. Neurohumoral and nitric oxide responses may influence cardiovascular performance during exercise. The aim of this study was evaluate associations between genetic polymorphisms of alpha-adrenergic receptors (ADRA1A, ADRA2A and ADRA2B), endothelial nitric oxide synthase (eNOS) and bradykin receptor B2 (BK2R) and treadmill exercise test responses in individuals without overt heart disease. Method: We enrolled 766 (417 women and 349 men) asymptomatic subjects. We selected the following variables during a maximal symptom-limited treadmill exercise test: exercise capacity, chronotropic reserve, maximum heart-rate achieved, heart-rate recovery, exercise systolic blood pressure, exercise diastolic blood pressure and systolic blood pressure recovery. Genotypes for the ADRA1A Arg347Cys (rs1048101), ADRA2A C1780T (rs553668), ADRA2B Del 301-303 (rs28365031), eNOS T786C (rs2070744), eNOS Glu298Asp (rs1799983) and BK2R (rs5810761) polymorphisms were assessed by polymerase chain reaction (PCR) followed by high resolution melting analysis. Laboratory and demographic data were collected for all participants. Statistical analysis was performed with multiple regression models for women and men. Results: The genotype frequencies were under Hardy-Weinberg equilibrium, except for the ADRA2B Del301-303 polymorphism. In the multivariated analysis the ADRA2A C1780T polymorphism was significantly associated with exercise diastolic blood pressure in both sexes. Exercise diastolic blood pressure was higher in individuals with TT genotype than in C allel carriers (P=0.003 for women; P=0.007 for men) (Table 1). The other polymorphisms did not influence significantly the treadmill exercise test responses. Conclusion: The ADRA2A C1780T influenced the exercise diastolic blood pressure in both sexes. This finding suggests that this polymorphism may be a marker of blood pressure response during exercise.
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    Trypanosoma cruzi cardiomyocyte infection promotes innate immune response and metabolic rewiring
    (2022) VENTURINI, Gabriela; ALVIM, Juliana; PADILHA, Kallyandra; TOEPFER, Christopher; GORHAM, Joshua; BIAGI, Diogo; SCHENKMAN, Sergio; CARVALHO, Valdemir; SALGUEIRO, Jessica; CARDOZO, Karina; KRIEGER, Jose; PEREIRA, Alexandre; SEIDMAN, Jonathan; SEIDMAN, Christine
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    Selection of candidate genes for hypertension on rat chromosome 4 from shr using expression profilling in kidney and subcongenic strain development
    (2013) TEIXEIRA, Samantha Kuwada; RODRIGUES, Mariliza Velho; MORALES, Marcelo Marcos; KRIEGER, Jose Eduardo
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    Heritability and correlation map of skin viscoelastic measurements with environmental and life style factors of Brazilian population
    (2015) AZAMBUJA, A. P.; NAKAMURA, M. S.; PIRES, T. F.; HORIMOTO, A. R.; ALVIM, R.; KRIEGER, J. E.; PEREIRA, A. C.
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    Stretch induces CRP3 expression in vein grafts
    (2012) CAMPOS, Luciene Cristina Gastalho; MIYAKAWA, Ayumi Aurea; BARAUNA, Valerio Garrone; BORIN, Thaiz Ferraz; DALLAN, Luis Alberto de Oliveira; KRIEGER, Jose Eduardo
    Cysteine- and glycine- rich protein 3 (CRP3) can act as structural protein and potent transcriptional cofactor during muscle differentiation and vascular remodeling. In this context, we have demonstrated, by real time RT–PCR, that CRP3 expression is 10 times higher in smooth muscle cells (SMCs) from human mammary artery vs. saphenous vein (h-SV) and that CRP3 expression can be induced in arterialized h-SV using an ex vivo flow through system that mimics arterial condition. The upregulation of CRP3 was primarily dependent on stretch stimulus in SMCs, rather than shear stress in ECs. Here, we assessed the induction and localization of CRP3 in SMCs during arterialization. Using a rat vein arterializations model in vivo, 1–14 days after surgery, CRP3 immunostaining was observed predominantly in the inner layer and 28–90 days it appears more scattered in the vessel. Confocal microscopy and western blot analysis showed that CRP3 is expressed in cytoplasm and nucleous of SMCs under stretch and in early stages of rat arterialization model. Later, the localization was restricted to the cytoplasm. Our data provide evidence that CRP3 is primarily expressed in arterial SMCs but upon stretching there is early expression of CRP3 induction in vein SMC cytoplasm and nucleous. These finding support to the idea that CRP3 may influence vascular adaptation to stress via cytoskeleton rearrangement and gene expression reprogramming.
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    IDENTIFICATION OF NOVEL GWAS HITS FOR SEMANTIC VERBAL FLUENCY: RESULTS FROM A FAMILY-BASED STUDY
    (2019) TAPOROSKI, Tamara; SCHANTZ, Malcolm Von; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; POMPEIA, Sabine; EVANS, Simon; KRIEGER, Jose E.; VALLADA, Homero; NEGRAO, Andre Brooking; PEREIRA, Alexandre C.
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    Activation of the AT1 receptor-beta-arrestin signaling pathway inhibits NHE3 activity in the renal proximal tubule
    (2014) MORAIS, Carla Carneiro de; OLIVEIRA-SOUZA, Maria; PESSOA, Thaissa; MALNIC, Gerhard; KRIEGER, Jose; GIRARDI, Adriana