CAMILLE PINTO FIGUEIREDO

(Fonte: Lattes)
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Lattes
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: Osteoporosis International ×

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  • conferenceObject
    PREVALENCE OF SARCOPENIA AND ASSOCIATED RISK FACTORS BY TWO DIAGNOSTIC CRITERIA IN COMMUNITY-DWELLING OLDER WOMEN: THE SAO PAULO AGEING & HEALTH STUDY (SPAH)
    (2016) DOMICIANO, D. S.; FIGUEIREDO, C. P.; LOPES, J. B.; CAPARBO, V. F.; TAKAYAMA, L.; MENEZES, P. R.; PEREIRA, R. M.
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  • article 43 Citação(ões) na Scopus
    Prevalence of sarcopenia and associated risk factors by two diagnostic criteria in community-dwelling older men: the So Paulo Ageing & Health Study (SPAH)
    (2014) FIGUEIREDO, C. P.; DOMICIANO, D. S.; LOPES, J. B.; CAPARBO, V. F.; SCAZUFCA, M.; BONFA, E.; PEREIRA, R. M. R.
    Sarcopenia is an aging syndrome that can be characterized by many criteria adjusted or not by fat mass. This study suggested that the optimal criteria should be selected according to body mass index (BMI) in older men and identified age, BMI, race, smoking, physical activity, hip bone mineral density (BMD) as risk factors for this syndrome. This study aims to analyze the prevalence of sarcopenia and associated risk factors using appendicular skeletal mass (ASM)/height(2) and ASM adjusted for total fat mass criteria in older men from community. Three hundred ninety-nine men were included and answered a questionnaire about lifestyle and medical history. Individuals were classified by their BMI using the classification adjusted by age. Body composition and bone mineral density were measured by dual X-ray absorptiometry. Sarcopenia was classified according to both criteria. Logistic regression models were used to analyze risk factors associated with sarcopenia. The mean BMI was 26.46 kg/m(2): 12.5 % underweight, 43.6 % normal, and 43.9 % overweight/obese. Fifty-four (13.5 %) were considered sarcopenic by ASM/height(2) and 79 (19.8 %) by ASM adjusted for fat (p = 0.001). Fifty-one (12.8 %) individuals had discordant sarcopenia classification: 13 were classified only by ASM/height(2) and 38 only by ASM adjusted for fat. Of the 13 subjects classified as sarcopenic only by ASM/height(2), 84.6 % (11/13) were underweight and solely one (7.7 %) was considered overweight/obese. In contrast, of those 38 older men classified as sarcopenic only by ASM adjusted for fat, none were underweight and 53 % (20/38) were overweight/obese. Subjects classified as sarcopenic according to both criteria had the same risk factors in the final model analyses (age, BMI, race, smoking, physical activity, hip BMD; p < 0.05). This study suggested that the optimal criteria for sarcopenia should be selected according to BMI in community-dwelling older men.
  • conferenceObject
    BONE MINERAL DENSITY AND PARATHYROID HORMONE AS INDEPENDENT RISK FACTORS FOR MORTALITY IN COMMUNITY-DWELLING OLDER ADULTS: A POPULATION-BASED PROSPECTIVE COHORT STUDY IN BRAZIL. THE SAO PAULO AGEING & HEALTH (SPAH) STUDY
    (2016) DOMICIANO, D.; MACHADO, L.; LOPES, J.; FIGUEIREDO, C.; CAPARBO, V.; TAKAYAMA, L.; OLIVEIRA, R.; SCAZUFCA, M.; MCCLUNG, M.; PEREIRA, R.
  • conferenceObject
    VERTEBRAL FRACTURE ASSESSMENT (VFA): A VALID TOOL TO DETECT VERTEBRAL FRACTURES IN COMMUNITY-DWELLING OLDER INDIVIDUALS - THE SAO PAULO AGEING & HEALTH STUDY (SPAH)
    (2012) DOMICIANO, D.; LOPES, J. B.; FIGUEIREDO, C. P.; CAPARBO, V.; TAKAYAMA, L.; BONFA, E.; PEREIRA, R. M. R.
    Aims: Vertebral fractures (VFx) are associated with higher morbidity and mortality in the general population. Since 70 % of the VFx are clinically silent, radiologic image of spine has to be acquired for the diagnosis. Vertebral Fracture Assessment (VFA) has emerged as possible alternative for the gold standard radiologic image to detect prevalent VFx. Previous studies evaluating this method are hampered by the limited sample size, selection of women with specific indication for spine X-ray and inclusion of patients under 70 years. Thus, the aim of this study was to compare the performance of VFA with X-ray to identify VFx in healthy community-dwelling older men and women. Methods: 429 noninstitutionalized subjects (60 % women), aged over 65 years, from community, were enrolled in this cohort. VFA by DXA measurements was evaluated by two expert rheumatologists by consensus and spine X-ray (T4 to L4) were analyzed according to semiquantitative method (Genant HK, 1993) by an expert radiologist. The correlation between VFA and spine X-ray to identify VFx was analyzed by kappa ( κ ) scores. P<0.05 was set as significant. Results: The average age ofsubjects was 73.1±5.1 years.The prevalence of VFx in VFA and X-ray were 29.7 and 28.6 % in women (p= 0.69), and 28.2 and 30.6 % in men (p=0.50), respectively. The frequency of unavailable vertebrae was significantly lower in spine X-ray than VFA (0.9 % and 5.6 %, respectively, p<0.001), particularly along with T4-T6. According to VFA, 5013 (96 %) vertebrae were identified as normal, 144 (2.7 %) had grade 1 fractures, 58 (1.1 %) grade 2 fractures and 12 (0.2) grade 3 fractures. The sensitivity of VFA was 72.93 % and the specificity was 99.1 % to identify VFx. The sensitivity increased to 92 % and specificity to 99.9 % excluding deformities grade 1. A good correlation between VFA and X-ray (κ=0.74) was observed and the exclusion of grade 1 resulted in an even better agreement(κ=0.84). The correlation vertebrae by vertebrae between VFA and spine X-ray was lower for T4-T7 (0.61-0.67). Correlations between the two methods were comparable in both gender (κ=0.73 in men,κ=0.75 in women). Conclusion: In elderly community, VFA and X-ray had comparable performances to identify VFx, particularly if mild deformities are excluded. Thus, this methodology is an easy and feasible promising alternative to improve the identification and management of patients with high risk of osteoporotic fractures.
  • conferenceObject
    VISCERAL FAT MEASURED BY DXA IS ASSOCIATED WITH INCREASED RISK OF NONSPINE FRACTURES IN NONOBESE ELDERLY WOMEN: A POPULATION-BASED PROSPECTIVE COHORT ANALYSIS FROM THE SAO PAULO AGEING & HEATHY (SPAH) STUDY
    (2016) MACHADO, L.; PEREIRA, R. M.; DOMICIANO, D.; FIGUEIREDO, C.; LOPES, J.; CAPARBO, V.; TAKAYAMA, L.; OLIVEIRA, R.; MENEZES, P.
  • conferenceObject
    ASSOCIATION BETWEEN METABOLIC SYNDROME AND BONE MINERAL DENSITY IN COMMUNITY-DWELLING OLDER WOMEN: THE SAO PAULO AGEING AND HEALTH STUDY (SPAH)
    (2017) MACHADO, L. G.; DOMICIANO, D. S.; FIGUEIREDO, C. P.; LOPES, J. B.; CAPARBO, V. F.; TAKAYAMA, L.; OLIVEIRA, R.; PEREIRA, R. M.
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    QUANTIFICATION AND IMPACT OF SECONDARY OSTEOARTHRITIS USING HR-PQCT IN ANTI-CITRULLINATED PROTEIN ANTIBODY RHEUMATOID ARTHRITIS PATIENTS
    (2017) FIGUEIREDO, C.; SIMON, D.; ENGLBRECHT, M.; HASCHKA, J.; KLEYER, A.; BAYAT, S.; HUEBER, A.; PEREIRA, R. M.; RECH, J.; SCHETT, G.
  • article 10 Citação(ões) na Scopus
    Associations between OPG and RANKL polymorphisms, vertebral fractures, and abdominal aortic calcification in community-dwelling older subjects: the Sao Paulo Ageing & Health Study (SPAH)
    (2016) PEREIRA, R. M. R.; FIGUEIREDO, C. P.; CHA, C. C.; CAPARBO, V. F.; OLIVEIRA, R. M.; FRANCO, A. S.; MENEZES, P. R.; CASTRO, I. de; ONUCHIC, L. F.
    This is the first study analyzing concomitantly osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) polymorphisms and OPG/RANKL serum levels and their association with bone mineral density (BMD), vertebral fractures, and vascular aortic calcification in a cohort of 800 subjects in community-dwelling older individuals. Introduction Osteoprotegerin (OPG) and RANKL play an important role in osteoclast activation and differentiation as well as in vascular calcification. At present, there are no studies of OPG or RANKL gene polymorphisms in Brazilian older populations. The aim of this study was to evaluate OPG/RANKL polymorphism and their association with vertebral fractures (VFs) and aortic calcification. Methods Eight hundred subjects (497 women/303 men) were genotyped for the OPG 1181G>C (rs2073618), 163C>T (rs3102735), 245T>G (rs3134069), and 209G>A (rs3134070) and RANKL A>G (rs2277438) single-nucleotide polymorphisms (SNPs). VFs were evaluated by spine radiography (Genant's method). Aortic calcification was quantified using Kauppila's method. Results The isolated genotype analyses and single-allele frequency data showed association of OPG 163C, 245G, and 209A alleles with presence of VFs (P < 0.05). Multiple logistic regression of subjects with absence of VFs vs. those with VFs (grades II/III) revealed only OPG 209A homozygosity as a risk factor for higher-grade VFs (odds ratio (OR) = 4.17, 95 % CI 1.03-16.93, P = 0.046). Regarding aortic calcification, the isolated genotype analysis frequency data revealed a significant association of OPG 1181G, 163C, 245G, and 209A alleles with absent aortic calcification (P < 0.05). Multiple logistic regression data confirmed that the OPG 209A allele was protective for aortic calcification (OR = 0.63, 95 % CI 0.45-0.88, P = 0.007) and the OPG 1181C allele was a risk factor for aortic calcification (OR = 1.26, 95 % CI 1.00-1.58, P = 0.046). Conclusion This study showed that the OPG 209AA genotype was a risk factor for higher-grade VFs, the OPG 209A allele was protective for aortic calcification, and the OPG 1181C was a risk factor for aortic calcification, supporting the involvement of OPG polymorphisms in the analyzed phenotypes and the concept that the related pathogenesis is multifactorial.
  • article 6 Citação(ões) na Scopus
    Persistent hypovitaminosis D and loss of hip bone mineral density over time as additional risk factors for recurrent falls in a population-based prospective cohort of elderly persons living in the community. The Sao Paulo Ageing & Health (SPAH) Study
    (2015) MACHADO, K. L. L. L.; DOMICIANO, D. S.; MACHADO, L. G.; LOPES, J. B.; FIGUEIREDO, C. P.; TAKAYAMA, L.; OLIVEIRA, R. M.; MENEZES, P. R.; PEREIRA, R. M. R.
    A Summary We performed concomitant evaluation of clinical, laboratory, and bone mineral density (BMD) parameters as potential risk factors for falls in a population-based prospective cohort of older adults, since previous studies have focused mostly in clinical risk factors. Loss of hip BMD and persistent hypovitaminosis D were associated with recurrent falls in community-dwelling elderly. Introduction Few studies have performed a concomitant evaluation of clinical data, laboratory bone parameters, and bone mineral density (BMD) to determine more accurately the contribution of each of these variables to risk of falls in elderly persons. We investigated the association between bone parameters and recurrent falls in a population-based prospective cohort of community-dwelling older adults. Methods A total of 705 elderly individuals (448 women, 257 men) were evaluated with clinical data, BMD, and laboratory bone tests at baseline and after a mean follow-up of 4.3 +/- 0.8 years. Individuals with recurrent falls (a parts per thousand yen2 falls in the previous year from the date of the second evaluation) were considered chronic fallers. Logistic regression models were used to identify independent risk factors for recurrent falls. Results The frequency of chronic fallers was 16.5 %. In multivariate analyses, risk factors for recurrent falls were visual impairment (odds ratio (OR) = 2.49, 95 % confidence interval (CI) 1.30-4.74, p = 0.006), use of psychotropic drugs (OR = 2.47, 95 % CI 1.37-4.49, p = 0.003), clinical fracture (OR = 2.78, 95 % CI 1.48-5.20, p = 0.001), persistently low 25-hydroxyvitamin D (25OHD) (< 20 ng/mL) (OR = 1.71, 95 % CI 1.10-2.64, p = 0.016), and loss of total hip BMD during the study (OR = 1.21, 95 % CI 1.17-1.25, p = 0.035 for each 4 % decrease). Conclusions In addition to traditional clinical risk factors for falls, loss of hip BMD and hypovitaminosis D were associated with recurrent falls in community-dwelling elderly persons. Thus, recognizing these factors is essential to preventing falls and improving the outcomes of this population.