DEBORAH DE SA PEREIRA BELFORT

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico

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  • article 16 Citação(ões) na Scopus
    Characteristics and Outcomes of Heart Transplant Recipients With Coronavirus-19 Disease in a High-volume Transplant Center
    (2022) MARCONDES-BRAGA, Fabiana G.; MURAD, Ciro M.; BELFORT, Deborah S. P.; DANTAS, Rafael C. T.; LIRA, Maria Tereza S. S.; ARAGAO, Carlos A. S.; SICILIANO, Rinaldo F.; MANGINI, Sandrigo; SEGURO, Luis Fernando B. C.; CAMPOS, Iascara W.; AVILA, Monica S.; BELLO, Mariana V. O.; SANTOS, Fernanda B. A. dos; V, Tania M. Strabelli; GAIOTTO, Fabio A.; BACAL, Fernando
    Background. Heart transplant (HT) recipients may be at higher risk of acquiring SARS-CoV-2 infection and developing critical illness. The aim of this study is to describe characteristics and outcomes of HT recipients infected by SARS-COV-2, from a high-volume transplant center. Methods. We have described data of all adult HT recipients with confirmed coronavirus disease 2019 by RT-PCR in nasopharyngeal samples from April 5, 2020, to January 5, 2021. Outcomes and follow-up were recorded until February 5, 2021. Results. Forty patients were included. Twenty-four patients (60%) were men; the median age was 53 (40-60) y old; median HT time was 34 mo; and median follow-up time 162 d. The majority needed hospitalization (83%). Immunosuppressive therapy was reduced/withdrawn in the majority of patients, except from steroids, which were maintained. Seventeen patients (42.5%) were classified as having severe disease according to the ordinal scale developed by the World Health Organization Committee. They tended to have lower absolute lymphocyte count (P < 0.001) during follow-up when compared with patients with mild disease. Thirty-day mortality was 12.5%. However, a longer follow-up revealed increased later mortality (27.5%), with median time to death around 35 d. Bacterial nosocomial infections were a leading cause of death. Cardiac allograft rejection (10%) and ventricular dysfunction (12.5%) were also not negligible. Conclusions. Major findings of this study corroborate other cohorts' results, but it also reports significant rate of later events, suggesting that a strict midterm surveillance is advisable to HT recipients with coronavirus disease 2019.