MARIA ESTHER JURFEST RIVERO CECCON
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Pediatria, Faculdade de Medicina
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- TLR-2 and TLR-4 mediated responses in monocytes from preterm and term newborns are distinct from those of adults(2012) SILVEIRA-LESSA, A. L.; QUINELLO, C.; CIANCIARULLO, M. A.; CECCON, M. E. J. R.; CARNEIRO-SAMPAIO, M.; PALMEIRA, P.
conferenceObject Detection of 22q11.2 Deletion in Infants with Congenital Heart Disease (Preliminary Data)(2013) CARNEIRO-SAMPAIO, M.; GRASSI, M. Sierro; KULIKOWSKI, L. Domenici; JACOB, C. Miuki Abe; DUTRA, R. Lelis; MIURA, N.; CECCON, M. E. Jurfest Rivero; KREBS, V. L. Jornada; CARVALHO, W. Brunow; JATENE, M.conferenceObject Phenotypic differences in leukocyte populations among septic and healthy preterm and full-term newborns(2012) QUINELLO, C.; SILVEIRA-LESSA, A. L.; RENNO, C.; CIANCIARULLO, M. A.; REDONDO, A. C. C.; CECCON, M. E. J. R.; CARNEIRO-SAMPAIO, M.; PALMEIRA, P.conferenceObject TLR-2 and TLR-4 mediated responses in monocytes from preterm and term newborns are distinct from those of adults(2012) SILVEIRA-LESSA, A. L.; QUINELLO, C.; CIANCIARULLO, M. A.; CECCON, M. E. J. R.; CARNEIRO-SAMPAIO, M.; PALMEIRA, P.- Cytokine profile of healthy preterm and term cord blood and peripheral blood of septic newborns(2012) QUINELLO, C.; SILVEIRA-LESSA, A. L.; CIANCIARULLO, M. A.; REDONDO, A. C. C.; CECCON, M. E. J. R.; CARNEIRO-SAMPAIO, M.; PALMEIRA, P.
conferenceObject Is prematurity associated with neonatal mortality in severe isolated congenital diaphragmatic hernia after fetal tracheal occlusion?(2013) RUANO, Rodrigo; SILVA, Marcos; GRASSI, Marcilia; CECCON, Maria; TANNURI, Uenis; ZUGAIB, MarceloOBJECTIVE: Fetoscopic tracheal occlusion (FETO) has been indicated for severe isolated CDH. However, this fetal intervention is related with prematurity (mean gestational age at delivery 35 weeks). In this study, we sought to evaluate if prematurity was associated with mortality after FETO. STUDY DESIGN: This is a prospective cohort study of 35 fetuses with severe isolatedCDHthat underwent FETO between 26-30 weeks. Preterm birth (<37 weeks) and extreme preterm birth (<32 weeks) were analyzed according to neonatal mortality using Fisher exact test. Other variables were also evaluated such as the lung-to-head ratio (LHR) prior to FETO, gestational age at FETO, duration of tracheal occlusion and duration of the procedure using t-test and Man-Whitney U test. RESULTS: Survival rate after FETO was 54.3%. Mean gestational age at delivery was 35.9±2.4 weeks in survivors and 34.9±2.8 weeks in those that died (p=0.28). Preterm birth and extreme preterm birth were not associated with mortality (p= 0.51 and p=0.34, respectively). The only variable associated with mortality was the LHR prior to FETO (0.73±0.02 vs. 0.84±0.09; p<0.01). CONCLUSION: In the present cohort of fetuses with severe CDH that underwent FETO, preterm birth and extreme preterm birth were not associated with mortality. The LHR prior to FETO can be used to predict outcome after tracheal occlusion performed between 26-30 weeks.conferenceObject Phagocytosis of Escherichia coli and Staphylococcus aureus by monocytes and neutrophils from septic and healthy preterm and term newborns(2012) QUINELLO, C.; SILVEIRA-LESSA, A. L.; RENNO, C.; CIANCIARULLO, M. A.; REDONDO, A. C. C.; CECCON, M. E. J. R.; CARNEIRO-SAMPAIO, M.; PALMEIRA, P.- Complement activity and regulation in premature, late premature and term neonates(2012) GRUMACH, A. S.; CECCON, M. E.; RUTZ, R.; KIRSCHFINK, M.Complement components (C3, C4, C5, C7, C9, factor B, C1inhibitor) are already synthesized early in fetal life although but present in early childhood with a relative deficiency in comparison with adult levels. Aim of this study was to evaluate a complement profile in premature (<34 weeks) and term babies focusing on the ontogeny of key regulatory proteins, which may allow an estimation of potential susceptibility to infection. Total complement activity (CH50, AP50), MBL, properdin, complement regulators (factors H, I and C1 Inhibitor) and C3a as marker of complement activation were assessed in three groups of healthy newborns in cord blood and at day 5 post partum: prematures from gestational age < 34 weeks (group 1), late premature from 34 to <37 weeks (group 2) and term neonates ≥37 weeks (group 3). Low, but age-related increasing CH50 values were observed in all three groups with lower titers in cord blood than in samples taken at day 5. Comparable low C3a levels excluded complement consumption as a consequence of activation. Plasma concentrations of C1 Inhibitor (protein and function) were below adult normal range only in preterm infants <34 weeks, but always lower in cord blood as compared those of 5th day. In contrast, factor I and the alternative pathway regulator, factor H, remained below normal adult range in all groups, even at day 5 pp. Levels of factor H and properdin increased with gestational age and no statistical significance among the 3 groups was detected for MBL levels. These results demonstrate the relative immaturity of the complement system and its regulators, especially in premature infants, predisposing to infections during the early neonatal period.
conferenceObject ACTIVE SEARCH FOR 22q11.2 DELETION IN INFANTS WITH CONGENITAL HEART DISEASE UNDERGOING CORRECTIVE SURGERY: PRELIMINARY RESULTS(2015) GRASSI, Marcilia Sierro; KULIKOWSKI, Leslie Domenici; JACOB, Cristina Miuki Abe; DUTRA, Roberta Lelis; ZANARDO, Evelin; CECCON, Maria Esther Jurfest Rivero; KREBS, Vera Lucia Jornada; IKARI, Nana Miura; JATENE, Marcelo Biscegli; CARVALHO, Werther Brunow; CARNEIRO-SAMPAIO, Magda