MONICA SAMUEL AVILA GRINBERG

(Fonte: Lattes)
Índice h a partir de 2011
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina

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Categoria: review × Assunto: Transplantation ×

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  • article 1 Citação(ões) na Scopus
    Transplantation for Chagas Heart Disease: a Comprehensive Review
    (2021) BACAL, Fernando; MURAD, Ciro Mancilha; ARAGAO, Carlos Aurelio dos Santos; CAMPOS, Iascara Wozniak de; SEGURO, Luis Fernando Bernal da Costa; AVILA, Monica Samuel; MANGINI, Sandrigo; GAIOTTO, Fabio Antonio; STRABELLI, Tania Varejao; MARCONDES-BRAGA, Fabiana G.
    Purpose of Review Chagas cardiomyopathy (CC) has a worse prognosis than other forms of cardiomyopathy and up to 10% of patients may progress to end-stage heart failure. In this article, we have performed a comprehensive literature review of heart transplantation (HT) for CC, including results after HT, management of immunosuppression, and Chagas disease (CD) reactivation. Recent Findings CD used to be considered a contraindication to HT due to the risks of disease reactivation with immunosuppression. Nonetheless, multiple reports have consistently demonstrated the feasibility and safety of HT for refractory CC. CD reactivation must be routinely screened in the first-year post-transplant, and in recent years, polymerase chain reactions (PCR)-based techniques have been used more often. HT is now considered the best treatment for end-stage Chagas heart disease. In addition, studies of immunosuppressive medications have shown that these patients require a lesser degree of immunosuppression, mainly to balance reactivation risks.