THAIS BIANCA BRANDAO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- The impact of radiation caries on morbidity and mortality outcomes of head and neck squamous cell carcinoma patients(2024) PALMIER, Natalia Rangel; PRADO-RIBEIRO, Ana Carolina; MARIZ, Bruno Augusto Linhares Almeida; RODRIGUES-OLIVEIRA, Leticia; PAGLIONI, Mariana de Pauli; NAPIMOGA, Juliana Trindade Clemente; PEDROSO, Caique Mariano; MORAIS-FARIA, Karina; OLIVEIRA, Maria Cecilia Querido de; VECHIATO-FILHO, Aljomar Jose; BRANDAO, Thais Bianca; SANTOS-SILVA, Alan RogerAimsRadiation caries (RC) is a highly prevalent and chronic complication of head and neck radiotherapy (HNRT) and presents a challenge for clinicians and patients. The present study aimed to assess the impact of RC on the morbidity and mortality outcomes of head and neck squamous cell carcinoma (HNSCC) patients. Methods and ResultsPatients were divided into three groups: (1) RC (n = 20), (2) control (n = 20), and (3) edentulous (n = 20). Information regarding the number of appointments, dental procedures, osteoradionecrosis (ORN), prescriptions, and hospital admissions were collected. Mortality outcomes were assessed through disease-free survival (DFS) and overall survival (OS) rates. RC patients required more dental appointments (p < .001), restorations (p < .001), extractions (p = .001), and antibiotic and analgesic prescriptions (p < .001). Kaplan-Meier subgroup analyses showed a significantly increased risk of ORN in RC compared to edentulous patients (p = .015). RC patients presented lower DFS rates (43.2 months) than the control and edentulous groups (55.4 and 56.1 months, respectively). ConclusionsRC impacts morbidity outcomes among cancer survivors due to increased demand for medication prescriptions, multiple specialized dental appointments, invasive surgical treatments, increased risk of ORN, and increased need for hospital admissions.
- Clinical characterization of stomatitis cases with an epithelial growth factor receptor inhibitor in metastatic colorectal cancer patients: A study of 7 cases and literature review(2023) GOMES-SILVA, Wagner; VECHIATO-FILHO, Aljomar Jose; LUIZ, Ana Claudia; GUOLLO, Andre; OLIVEIRA, Maria Cecilia Querido de; GOMES, Mauricio Neves; CAPARELLI, Fernanda Cunha; BRANDAO, Thais BiancaObjective. The aim of this study was to reporta case series of patients with metastatic colorectal cancer (mCRC) undergoing panitumumab-containing regimens affected by oral lesions and to review the current literature.Study design. Electronic medical records of mCRC patients referred to treat mouth sores during the treatment with the anti-epithelial growth factor receptor (EGFR)-panitumumab-were retrospectively reviewed. Patients' characterization, clinical profile of oral lesions, and management outcomes were documented. Additionally, modifications or discontinuation of the antineo-plastic treatment as well as the occurrence of other adverse events (AEs) were analyzed.Results. A total of 7 patients were included. The oral lesions appeared in a median time of 10 days (range 7-11 days) after the drug administration. The median reported pain score was 5 (range 1-9), causing feeding discomfort. Oral lesions with a marked aphthous-like appearance, among others, occurred in all cases and involved nonkeratinized mucosa more likely. At least 1 patient had dose reduction of the treatment and 1 patient needed discontinuation due to panitumumab-associated stomatitis. Dermatologic AEs were the most prevalent. Clinical improvement was obtained with topical corticosteroid therapy and/or photobiomodulation.Conclusions. In summary, panitumumab-containing regimens were associated with a particular pattern of oral lesions consistent with stomatitis. This event may eventually affect the tolerability of the treatment in patients with mCRC. (Oral Surg Oral Med Oral Pathol Oral Radiol 2023;136:162-172)
- Are intraoral stents effective in reducing oral toxicities caused by radiotherapy? A systematic review and meta-analysis(2022) BRANDAO, Thais Bianca; PINTO, Henrique da Graca; VECHIATO FILHO, Aljomar Jose; FARIA, Karina Morais; OLIVEIRA, Maria Cecilia Querido de; PRADO-RIBEIRO, Ana Carolina; DIAS, Reinaldo Brito; SANTOS-SILVA, Alan Roger; BATISTA, Victor Eduardo de SouzaStatement of problem. Intraoral stents have been provided to minimize acute and chronic toxicities induced by radiotherapy, including oral mucositis, salivary changes, trismus, radiation-related caries, and osteoradionecrosis. However, a systematic review and meta-analysis is necessary to determine their effectiveness. Purpose. The purpose of this systematic review and meta-analysis was to determine the effectiveness of intraoral stent use and determine whether these prosthetic devices can reduce radiation dosage to nontargeted oral tissues and adverse effects related to head and neck radiation. Material and methods. Two independent reviewers made a systematic search for articles published from January 2010 to March 2020 in 3 databases, supplemented by a manual search. Studies were included if they were clinical trials (randomized controlled trials, both prospective and retrospective), published in English, and evaluated radiation dose and oral adverse side effects (acute or chronic) induced by radiotherapy of participants with and without intraoral stents. Results. The search strategy identified 201 studies; of which, 9 were included. A total of 251 participants were evaluated; of whom, 168 (77.3%) used intraoral stents and 57 (22.7%) were treated with radiotherapy without a prosthetic device. A statistically significant difference was found regarding the use of intraoral stents for preventing oral mucositis (P<.001), salivary changes (P=.003), and trismus (P<.02). A funnel plot showed asymmetry among the differences of means in all selected studies. Conclusions. Intraoral stents have a positive effect on preventing oral mucositis. Further clinical trials are needed to address the flaws identified in the present systematic review.
- Radiation-related caries: current diagnostic, prognostic, and management paradigms(2020) PALMIER, Natalia Rangel; MIGLIORATI, Cesar Augusto; PRADO-RIBEIRO, Ana Carolina; OLIVEIRA, Maria Cecilia Querido de; VECHIATO FILHO, Aljomar Jose; GOES, Mario Fernando de; BRANDAO, Thais Bianca; LOPES, Marcio Ajudarte; SANTOS-SILVA, Alan RogerObjective and study design. This narrative review summarizes the current state of art of radiation-related caries (RC), an aggressive disease that affects approximately 30% of post-head and neck radiotherapy (HNRT) patients. Results. RC mainly affects the tooth cervical areas and incisal/cuspal tips and develops 6 to 12 months after HNRT. Early RC signs include black/brownish tooth discoloration and enamel cracks, which progress to enamel delamination, exposing underlying dentin to a highly cariogenic oral environment and rapid tooth destruction/dental crown amputation. As RC advances and renders the tooth nonrestorable, it may lead to osteoradionecrosis spontaneously or upon extraction if the tooth is in a highly irradiated field of the oral cavity. This requires aggressive treatment, which would have a negative impact on a cancer survivor's quality of life and contribute to the incremental cost of cancer care. Chlorhexidine mouth rinses and topical fluoride applications are effective agents used in RC prevention; however, there are no well-established treatment protocols. Once RC progresses, dental restorations should be performed with adhesive materials in association with systematic fluoride application as illustrated in the clinical case presented in this review. Post-HNRT patients should be closely followed up for optimal RC prevention, early diagnosis, and prompt treatment. Conclusions. Future clinical studies are necessary to establish a contemporary, clinically validated protocol for RC management.