THAIS BIANCA BRANDAO

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Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina

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  • article 2 Citação(ões) na Scopus
    The impact of radiation caries on morbidity and mortality outcomes of head and neck squamous cell carcinoma patients
    (2024) PALMIER, Natalia Rangel; PRADO-RIBEIRO, Ana Carolina; MARIZ, Bruno Augusto Linhares Almeida; RODRIGUES-OLIVEIRA, Leticia; PAGLIONI, Mariana de Pauli; NAPIMOGA, Juliana Trindade Clemente; PEDROSO, Caique Mariano; MORAIS-FARIA, Karina; OLIVEIRA, Maria Cecilia Querido de; VECHIATO-FILHO, Aljomar Jose; BRANDAO, Thais Bianca; SANTOS-SILVA, Alan Roger
    AimsRadiation caries (RC) is a highly prevalent and chronic complication of head and neck radiotherapy (HNRT) and presents a challenge for clinicians and patients. The present study aimed to assess the impact of RC on the morbidity and mortality outcomes of head and neck squamous cell carcinoma (HNSCC) patients. Methods and ResultsPatients were divided into three groups: (1) RC (n = 20), (2) control (n = 20), and (3) edentulous (n = 20). Information regarding the number of appointments, dental procedures, osteoradionecrosis (ORN), prescriptions, and hospital admissions were collected. Mortality outcomes were assessed through disease-free survival (DFS) and overall survival (OS) rates. RC patients required more dental appointments (p < .001), restorations (p < .001), extractions (p = .001), and antibiotic and analgesic prescriptions (p < .001). Kaplan-Meier subgroup analyses showed a significantly increased risk of ORN in RC compared to edentulous patients (p = .015). RC patients presented lower DFS rates (43.2 months) than the control and edentulous groups (55.4 and 56.1 months, respectively). ConclusionsRC impacts morbidity outcomes among cancer survivors due to increased demand for medication prescriptions, multiple specialized dental appointments, invasive surgical treatments, increased risk of ORN, and increased need for hospital admissions.