THAIS BIANCA BRANDAO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
62 resultados
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Agora exibindo 1 - 10 de 62
- Clinical predictors of malignant transformation and recurrence in oral potentially malignant disorders: A systematic review and meta-analysis(2022) PAGLIONI, Mariana de Pauli; KHURRAM, Syed Ali; RUIZ, Blanca Iciar Indave; LAUBY-SECRETAN, Beatrice; NORMANDO, Ana Gabriela; RIBEIRO, Ana Carolina Prado; BRANDAO, Thais Bianca; PALMIER, Natalia Rangel; LOPES, Marcio Ajudarte; GUERRA, Eliete Neves da Silva; MELETI, Marco; MIGLIORATI, Cesar Augusto; CARVALHO, Andre Lopes; MATOS, Leandro Luongo de; KOWALSKI, Luiz Paulo; SANTOS-SILVA, Alan RogerObjective. We performed a systematic review dedicated to pooling evidence for the associations of clinical features with malignant transformation (MT) and recurrence of 3 oral potentially malignant disorders (OPMDs) (actinic cheilitis [AC], oral leukoplakia [OL], and proliferative verrucous leukoplakia [PVL]). Study Design. We selected studies that included clinical features and risk factors (age, sex, site, size, appearance, alcohol intake, tobacco use, and sun exposure) of OL, PVL, and AC associated with recurrence and/or MT. Results. Based on the meta-analysis results, non-homogeneous OL appears to have a 4.53 times higher chance of recurrence after treatment. We also found 6.52 higher chances of MT of non-homogeneous OL. Another clinical feature related to higher MT chances is the location (floor of the mouth and tongue has 4.48 higher chances) and the size (OL with >200 mm2 in size has 4.10 higher chances of MT). Regarding habits, nonsmoking patients with OL have a 3.20 higher chance of MT. The only clinical feature related to higher chances of MT in patients with PVL was sex (females have a 2.50 higher chance of MT). Conclusions. Our study showed that some clinical features may indicate greater chances of recurrence after treatment and MT of OPMD.
- The wolf in sheep's clothing: Microtomographic aspects of clinically incipient radiation-related caries(2016) MORAIS-FARIA, Karina; NEVES-SILVA, Rodrigo; LOPES, Marcio-Ajudarte; RIBEIRO, Ana-Carolina-Prado; CASTRO JR., Gilberto de; CONCEICAO-VASCONCELOS, Karina-Gondim-Moutinho da; BRANDAO, Thais-Bianca; SANTOS-SILVA, Alan-RogerBackground: Radiation-related caries (RRC) can cause rapid progression, with a high potential for dental destruction affecting mainly cervical and incisal areas. Unlike the injuries that occur in the conventional caries, incipient RRC present in unusual surfaces have difficult diagnosis and classification stages of cavitation. Material and Methods: Evaluate the radiographic patterns of demineralization of RRC by using micro-CT. Ten teeth with incipient RRC and 10 teeth with incipient conventional caries (control group) matched by anatomic teeth group and caries affected surfaces were evaluated by X-ray microtomography (micro-CT) Skyscan 1174V2 (50Kv, 1.3 megapixel, Kontich, Belgium). Teeth were placed in a standard position for micro-CT (coronal, transaxial and sagittal sections) during images acquisition. Lesions were classified according to the depth of invasion and relationship with enamel, dentin and pulp. Results: RRC samples presented deeper lesions with higher involvement of enamel and dentin. Control group presented focal and superficial lesions with lower involvement of enamel and dentin. Conclusions: Incipient RRC present aggressive microtomographic patterns of demineralization when compared to conventional caries, as indicated by deep lesions, regardless of its clinically incipient aspects.
- The impact of radiation caries on morbidity and mortality outcomes of head and neck squamous cell carcinoma patients(2024) PALMIER, Natalia Rangel; PRADO-RIBEIRO, Ana Carolina; MARIZ, Bruno Augusto Linhares Almeida; RODRIGUES-OLIVEIRA, Leticia; PAGLIONI, Mariana de Pauli; NAPIMOGA, Juliana Trindade Clemente; PEDROSO, Caique Mariano; MORAIS-FARIA, Karina; OLIVEIRA, Maria Cecilia Querido de; VECHIATO-FILHO, Aljomar Jose; BRANDAO, Thais Bianca; SANTOS-SILVA, Alan RogerAimsRadiation caries (RC) is a highly prevalent and chronic complication of head and neck radiotherapy (HNRT) and presents a challenge for clinicians and patients. The present study aimed to assess the impact of RC on the morbidity and mortality outcomes of head and neck squamous cell carcinoma (HNSCC) patients. Methods and ResultsPatients were divided into three groups: (1) RC (n = 20), (2) control (n = 20), and (3) edentulous (n = 20). Information regarding the number of appointments, dental procedures, osteoradionecrosis (ORN), prescriptions, and hospital admissions were collected. Mortality outcomes were assessed through disease-free survival (DFS) and overall survival (OS) rates. RC patients required more dental appointments (p < .001), restorations (p < .001), extractions (p = .001), and antibiotic and analgesic prescriptions (p < .001). Kaplan-Meier subgroup analyses showed a significantly increased risk of ORN in RC compared to edentulous patients (p = .015). RC patients presented lower DFS rates (43.2 months) than the control and edentulous groups (55.4 and 56.1 months, respectively). ConclusionsRC impacts morbidity outcomes among cancer survivors due to increased demand for medication prescriptions, multiple specialized dental appointments, invasive surgical treatments, increased risk of ORN, and increased need for hospital admissions.
- Impact of head and neck radiotherapy on the mechanical behavior of composite resins and adhesive systems: A systematic review(2017) TROCONIS, Cristhian Camilo Madrid; SANTOS-SILVA, Alan Roger; BRANDAO, Thais Bianca; LOPES, Marcio Ajudarte; GOES, Mario Fernando deObjective. To analyze the evidence regarding the impact of head and neck radiotherapy (HNRT) on the mechanical behavior of composite resins and adhesive systems. Methods. Searches were conducted on PubMed, Embase, Scopus and ISI Web of Science databases using ""Radiotherapy"", "" Composite resins"" and ""Adhesivesystems"" as keywords. Selected studies were written in English and assessed the mechanical behavior of composite resins and/or adhesive systems when bonding procedure was conducted before and/or after a maximum radiation dose >= 50 Gy, applied under in vitro or in vivo conditions. Results. In total, 115 studies were found but only 16 were included, from which five evaluated the effect of in vitro HNRT on microhardness, wear resistance, diametral tensile and flexural strength of composite resins, showing no significant negative effect in most of reports. Regarding bond strength of adhesive systems, 11 studies were included from which five reported no meaningful negative effect when bonding procedure was conducted before simulated HNRT. Conversely, five studies showed that bond strength diminished when adhesive procedure was done after in vitro radiation therapy. Only two studies about dental adhesion were conducted after in vivo radiotherapy but the results were not conclusive. Significance. The mechanical behavior of composite resins and adhesive systems seems not to be affected when in vitro HNRT is applied after bonding procedure. However, bond strength of adhesive systems tends to decrease when simulated radiotherapy is used immediately before bonding procedure. Studies assessing dentin bond strength after in-vivo HNRT were limited and controversial.
conferenceObject IMRT delivers lower radiation doses to dental structures than 3DRT in head and neck cancer patients(2016) FREGNANI, E. R.; PARAHYBA, C. Joffily; MORAIS-FARIA, K.; FONSECA, F. Paiva; RAMOS, P. A. Mendes; MORAES, F. Yone de; VASCONCELOS, K. Gondim Moutinho da Conceicao; MENEGUCCI, G.; SANTOS-SILVA, A. R.; BRANDAO, T. B.- Clinical outcomes of dental implants in head and neck cancer patients: An overview(2023) MARQUES, Nelson Pereira; PEREZ-DE-OLIVEIRA, Maria Eduarda; NORMANDO, Ana Gabriela Costa; MARQUES, Nadia Carolina Teixeira; EPSTEIN, Joel B.; MIGLIORATI, Cesar A.; MARTELLI JUNIOR, Hercilio; RIBEIRO, Ana Carolina Prado; ROCHA, Andre Caroli; BRANDAO, Thais Bianca; SANCHEZ, Francisco German Villanueva; GUEIROS, Luiz Alcino Monteiro; LOPES, Marcio Ajudarte; SANTOS-SILVA, Alan RogerObjective. The aim of this study was to evaluate the clinical outcomes of dental implants (DIs) in patients with head and neck can-cer (HNC) treated with radiotherapy (RT), isolated chemotherapy, or bone modifying agents (BMAs). Study Design. This study was registered in the Prospective Register of Systematic Reviews (CRD42018102772); conducted via the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist; and based on PubMed, Scopus, Embase, Cochrane Library, Web of Science, and gray literature searches. The selection of studies was performed in 2 phases by 2 independent reviewers. The risk of bias (RoB) was assessed by the Measurement Tool to Assess the Methodological Quality of Systematic Reviews 2. Results. Twenty systematic reviews were included in the qualitative analysis. The majority scored as having high RoB (n = 11). Pri-mary DIs placement in the mandible of patients with HNC subjected to RT doses <50 Gy was associated with better survival rates. Conclusions. The placements of DIs could be considered safe in patients with HNC in sites of alveolar bone that received RT (<5000 Gy); however, no conclusions could be made in patients with cancer managed by chemotherapy or BMAs. Due to the heterogeneity of studies included, the recommendation for DIs placement in patients with cancer should be carefully considered. Future better controlled randomized clinical trials are required to provide enhanced clinical guidelines for best patient care. (Oral Surg Oral Med Oral Pathol Oral Radiol 2023;136:42-53)
- Obituary: Dr. Wagner Gomes Silva (1990-2023)(2023) SANTOS-SILVA, Alan Roger; BRANDAO, Thais Bianca
- Impact of head and neck radiotherapy on the longevity of dental adhesive restorations: A systematic review and meta-analysis(2022) PALMIER, Natalia Rangel; TROCONIS, Cristhian Camilo Madrid; NORMANDO, Ana Gabriela Costa; GUERRA, Eliete Neves Silva; ARAUJO, Anna Luiza Damaceno; ARBOLEDA, Lady Paola Aristizabal; FONSECA, Jessica Montenegro; PAGLIONI, Mariana de Pauli; GOMES-SILVA, Wagner; VECHIATO FILHO, Aljomar Jose; GONZALEZ-ARRIAGADA, Wilfredo Alejandro; LEME, Adriana Franco Paes; PRADO-RIBEIRO, Ana Carolina; BRANDAO, Thais Bianca; GOES, Mario Fernando de; LOPES, Marcio Ajudarte; SANTOS-SILVA, Alan RogerStatement of problem. Established restorative protocols for patients after head and neck radiotherapy are lacking, increasing the failure rates of dental adhesive restorations. Purpose. The purpose of this systematic review and meta-analysis was to analyze the evidence regarding the impact of head and neck radiotherapy on the longevity of dental adhesive restorations. Material and methods. A search was performed using PubMed, Scopus, and Embase in May 2018 (updated in November 2020). Data extraction was performed regarding the percentage of restoration failure among dental adhesive materials, including glass ionomer cements, resin-modified glass ionomer cements, and composite resins. Risk of bias was assessed by the meta-analysis of statistics assessment and review instrument (MAStARI). Confidence in cumulative evidence was evaluated by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) protocol. Results. Four studies met the inclusion criteria. All included studies were classified as having a moderate risk of bias and reported results regarding class V restorations. Overall, composite resins presented lower failure rates at 2 years (30%) when compared with resin-modified glass ionomer (41%) and glass ionomer cements (57%). Meta-analysis showed that the risk of failure with glass ionomer cements was greater than with resin-modified glass ionomer cements (RR: 1.71, P<.001). Composite resins presented lower risk of failure when compared with glass ionomer (RR: 2.29, P<.001) and resin-modified glass ionomer cements (RR: 1.30, P=.03). Three studies reported results regarding fluoride compliance, which had a negative effect on the survival rates of glass ionomer and resin-modified glass ionomer cements and a positive effect on composite resin restorations. Conclusions. The results suggest that composite resin restorations associated with fluoride gel compliance seems to be the best alternative for restoring class V lesions in patients after head and neck radiotherapy. However, the results showed moderate certainty of evidence, which justifies the need for more randomized clinical trials regarding this subject. (J Prosthet Dent 2022;128:886-96)
- Extranodal NK/T cell lymphoma, nasal type: An updated overview(2021) SANCHEZ-ROMERO, Celeste; BOLOGNA-MOLINA, Ronell; ALMEIDA, Oslei Paes de; SANTOS-SILVA, Alan Roger; PRADO-RIBEIRO, Ana Carolina; BRANDAO, Thais Bianca; CARLOS, RomanExtranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is an aggressive malignancy associated with Epstein Barr virus infection, with a geographic and racial predilection for some Asian and Latin American countries. ENKTCL-NT manifests as a necrotic process affecting nasal or upper aerodigestive structures and, rarely, extranasal sites such as skin, and the gastrointestinal tract. ENKTCL-NT was characterized by its poor prognosis irrespective of clinical stage and therapy. However, during the last two decades, advances in its clinicopathologic, genetic and molecular characterization have been achieved, as have changes in the chemotherapy regimens that, in combination with radiotherapy, are significantly improving the survival of these patients, especially in initial stages. For these reasons, we present an overview of the historical background of ENKTCL-NT along with an updated review of its potential etiological factors, clinicopathologic and molecular features, as well as its prognostic models, current treatment protocols, and future directions on potential promising therapeutic approaches.
- IMRT delivers lower radiation doses to dental structures than 3DRT in head and neck cancer patients(2016) FREGNANI, Eduardo Rodrigues; PARAHYBA, Claudia Joffily; MORAIS-FARIA, Karina; FONSECA, Felipe Paiva; RAMOS, Pedro Augusto Mendes; MORAES, Fabio Yone de; VASCONCELOS, Karina Gondim Moutinho da Conceicao; MENEGUSSI, Gisela; SANTOS-SILVA, Alan Roger; BRANDAO, Thais B.Background: Radiotherapy (RT) is frequently used in the treatment of head and neck cancer, but different side-effects are frequently reported, including a higher frequency of radiation-related caries, what may be consequence of direct radiation to dental tissue. The intensity-modulated radiotherapy (IMRT) was developed to improve tumor control and decrease patient's morbidity by delivering radiation beams only to tumor shapes and sparing normal tissue. However, teeth are usually not included in IMRT plannings and the real efficacy of IMRT in the dental context has not been addressed. Therefore, the aim of this study is to assess whether IMRT delivers lower radiation doses to dental structures than conformal 3D radiotherapy (3DRT). Material and methods: Radiation dose delivery to dental structures of 80 patients treated for head and neck cancers (oral cavity, tongue, nasopharynx and oropharynx) with IMRT (40 patients) and 3DRT (40 patients) were assessed by individually contouring tooth crowns on patients' treatment plans. Clinicopathological data were retrieved from patients' medical files. Results: The average dose of radiation to teeth delivered by IMRT was significantly lower than with 3DRT (p = 0. 007); however, only patients affected by nasopharynx and oral cavity cancers demonstrated significantly lower doses with IMRT (p = 0.012 and p = 0.011, respectively). Molars received more radiation with both 3DRT and IMRT, but the latter delivered significantly lower radiation in this group of teeth (p < 0.001), whereas no significant difference was found for the other dental groups. Maxillary teeth received lower doses than mandibular teeth, but only IMRT delivered significantly lower doses (p = 0.011 and p = 0.003). Ipsilateral teeth received higher doses than contralateral teeth with both techniques and IMRT delivered significantly lower radiation than 3DRT for contralateral dental structures (p < 0.001). Conclusion: IMRT delivered lower radiation doses to teeth than 3DRT, but only for some groups of patients and teeth, suggesting that this decrease was more likely due to the protection of other high risk organs, and was not enough to remove teeth from the zone of high risk for radiogenic disturbance (>30Gy).