RENATO FRAGA RIGHETTI
Projetos de Pesquisa
Unidades Organizacionais
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- Anti-IL17 treatment control responses in lung injury induced by elastase(2018) FUKUZAKI, Silvia; GARRIDO, Aurelio C.; RIGHETTI, Renato F.; SANTOS, Tabata M.; CAMARGO, Leandro N.; ARISTOTELES, Luciana R. C. R. B.; SOUZA, Flavia C. R.; SARAIVA-ROMANHOLO, Beatriz M.; LEICK, Edna A.; PRADO, Carla M.; MARTINS, Milton A.; TIBERIO, Iolanda F. L. C.
- Inflammation and remodeling modulated by anti IL17 in model of lung injury induced by elastase in mice(2019) LEICK, Edna A.; FUKUZAKI, Silvia; RIGHETTI, Renato F.; SANTOS, Tabata M.; CAMARGO, Leandro N.; GARRIDO, Aurelio C.; ARISTOTELES, Luciana R. C. R. B.; SOUZA, Flavia C. R.; SARAIVA-ROMANHOLO, Beatriz M.; PRADO, Carla M.; MARTINS, Milton A.; TIBERIO, Iolanda F. L. C.
- Effects of anti-IL-17 on inflammation and oxidative stress in an ASTHMA-COPD overlap syndrome (ACO) model(2021) CAMARGO, Leandro D. N.; MARTINS, Nilo; ALMEIDA, Francine M. D.; LOURENCO, Juliana; BEZERRA, Suellen; SANTOS, Tabata M. D.; FUKUZAKI, Silvia; LOPES, Fernanda D. T. Q. D. S.; MARTIN, Milton M.; LEICK, Edna A.; RIGHETTI, Renato F.; PRADO, Carla M.; TIBERIO, Iolanda D. F. L. C.
- Specific NFKappaB and Rho-Quinase inhibitors compared to corticosteroid in asthma model in mice(2017) SOUZA, Flavia; CAMARGO, Leandro; RIGHETTI, Renato; ARISTOTELES, Luciana; MARUYAMA, Tabata; FUKUZAKI, Silvia; LEICK, Edna; MARTINS, Milton; PRADO, Carla; TIBERIO, Iolanda; ROMANHOLO, Beatriz
- Effects of anti-IL17 on acute lung injury induced by LPS in mice(2017) RIGHETTI, Renato; SANTOS, Tabata Maruyama dos; CAMARGO, Leandro do Nascimento; ARISTOTELES, Luciana Ritha de Cassia Rolim Barbosa; FUKUZAKI, Silvia; SOUZA, Flavia Castro Ribas de; CRUZ, Maysa Mariana; ALONSO-VALE, Maria Isabel Cardoso; SARAIVA-ROMANHOLO, Beatriz Mangueira; LEICK, Edna Aparecida; MARTINS, Milton de Arruda; PRADO, Carla Maximo; TIBERIO, Iolanda de Fatima Lopes Calvo
- Bronchial vascular remodeling is attenuated by anti-IL17 in asthmatic responses exacerbated by LPS(2019) CAMARGO, Leandro; ANDRADE, Felipp Costa Pinto De; SANTOS, Tabata M.; FUKUZAKI, Silvia; PRADO, Carla Maximo; MARTINS, Milton Arruda; LEICK, Edna Aparecida; RIGHETTI, Renato Fraga; TIBERIO, Iolanda De Fatima Lopes Calvo
- Effects of anti-IL17 on inflammation, remodeling, and oxidative stress in an experimental model of asthma exacerbated by LPS(2018) CAMARGO, Leandro; RIGHETTI, Renato F.; ARISTOTELES, Luciana R. C. R. B.; SANTOS, Tabata M.; SOUZA, Flavia C. R.; FUKUZAKI, Silvia; CRUZ, Maysa M.; ALONSO-VALE, Maria Isabel C.; SARAIVA-ROMANHOLO, Beatriz M.; PRADO, Carla M.; MARTINS, Milton A.; LEICK, Edna A.; TIBERIO, Iolanda F. L. C.
- Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation(2020) SANTOS, Tabata M. dos; RIGHETTI, Renato F.; REZENDE, Bianca G.; CAMPOS, Elaine C.; CAMARGO, Leandro do N.; SARAIVA-ROMANHOLO, Beatriz M.; FUKUZAKI, Silvia; PRADO, Carla M.; LEICK, Edna A.; MARTINS, Milton A.; TIBERIO, Iolanda F. L. C.Background and aims: Expansion and morphological dysregulation of the bronchial vascular network occurs in asthmatic airways. Interleukin (IL) -17 and Rho-kinase (ROCK) are known to act in inflammation control and remodeling. Modulation of Rho-kinase proteins and IL-17 may be a promising approach for the treatment of asthma through the control of angiogenesis. Our objective was to analyze the effects of treatment with anti-IL17 and/or Rho-kinase inhibitor on vascular changes in mice with chronic allergic pulmonary inflammation. Methods: Sixty-four BALB/c mice, with pulmonary inflammation induced by ovalbumin were treated with anti-IL17A (7.5/mu g per dose, intraperitoneal) and/or Rho-kinase inhibitor (Y-27632-10 mg/kg, intranasal), 1 h before each ovalbumin challenge (22, 24, 26, and 28/days). Control animals were made to inhale saline. At the end of the protocol, lungs were removed, and morphometric analysis was performed to quantify vascular inflammatory, remodeling, and oxidative stress responses. Results: Anti-IL17 or Rho-kinase inhibitor reduced the number of CD4(+), CD8(+), dendritic cells, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, Rho-kinase 1 and 2, transforming growth factor (TGF-beta), vascular endothelial growth factor (VEGF), nuclear factor (NF)-KappaB, iNOS, metalloproteinase (MMP)-9, MMP-12, metalloproteinase inhibitor-1 (TIMP-1), FOXP-3, signal transducer and activator of transcription 1 (STAT1) and phospho-STAT1-positive cells, and actin, endothelin-1, isoprostane, biglycan, decorin, fibronectin and the collagen fibers volume fraction compared with the ovalbumin group (p < 0.05). The combination treatment, when compared with anti-IL17, resulted in potentiation of decrease in the number of IL1 beta- and dendritic cells-positive cells. When we compared the OVA-RHO inhibitor-anti-IL17 with OVA-RHO inhibitor we found a reduction in the number of CD8(+) and IL-17, TGF-beta, and phospho-STAT1-positive cells and endothelin-1 in the vessels (p < 0.05). There was an attenuation in the number of ROCK 2-positive cells in the group with the combined treatment when compared with anti-IL17 or Rho-kinase inhibitor-treated groups (p < 0.05). Conclusion: We observed no difference in angiogenesis after treatment with Rho-kinase inhibitor and anti-IL17. Although the treatments did not show differences in angiogenesis, they showed differences in the markers involved in the angiogenesis process contributing to inflammation control and vascular remodeling. The reviews of this paper are available via the supplemental material section.
- Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodelling in an asthma model in mice(2019) SANTOS, Tabata M.; CAMPOS, Elaine C.; RIGUETTI, Renato F.; CAMARGO, Leandro N.; FUKUZAKI, Silvia; REZENDE, Bianca G.; SARAIVA-ROMANHOLO, Beatriz M.; PRADO, Carla M.; LEICK, Edna A.; MARTINS, Milton A.; TIBERIO, Iolanda F. L. C.