RENATO FRAGA RIGHETTI
Projetos de Pesquisa
Unidades Organizacionais
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- Effects of environmental exposure to iron powder in an elastase mice model(2022) GALLI, T. Tafarel; CAMPOS, E. C.; SANTOS, T. M.; FUKUZAKI, S.; CAMARGO, L. N.; BEZERRA, S. K. M.; HAMAGUCHI, S. S. S.; SILVA, F. J. A. Da; SARAIVA-ROMANHOLO, B. M.; OLIVO, C. R.; PRADO, C. M.; LOPES, F. Degobbi Tenorio Quirino Dos Santos; LEICK, E. A.; BOUROTTE, C. L. M.; BENSENOR, I. J. M.; LOTUFO, P. A.; RIGHETTI, R. F.; TIBERIO, I. F. L. C.
conferenceObject Does Treatment with a Plant Proteinase Inhibitor, Enterolobium Contortisiliquum Contribute to the Control of Inflammation, Remodeling and Oxidative Stress in Mice with Asthma-COPD Overlap (ACO)?(2022) CAMARGO, L.; BARBOSA, J.; SILVA, L.; JOAO, J.; SANTOS, H.; SARAIVA-ROMANHOLO, B.; FUKUZAKI, S.; BEZERRA, S.; PRADO, C.; LOPES, F.; OLIVA, M.; RIGHETTI, R.; LEICK, E.; TIBERIO, I.conferenceObject Plant Protease Inhibitors Had an Effect on Controlling Lung Inflammation, Remodeling and Oxidative Stress in Mice with ASTHMA-COPD Overlap: Comparison with Corticosteroid(2022) RIGHETTI, R. F.; JOAO, J.; BARBOSA, J.; SILVA, L.; FUKUZAKI, S.; CAMARGO, L.; SARAIVA-ROMANHOLO, B.; BEZERRA, S.; PRADO, C. M.; LOPES, F. D.; OLIVA, M.; LEICK, E. A.; TIBERIO, I. F. L. C.- Resilience and its impact on the mental health of physiotherapists during the COVID-19 pandemic in Sa?o Paulo, Brazil(2022) PIGATI, Patricia Angeli da Silva; RIGHETTI, Renato Fraga; NISIAYMAMOTO, Bruna Tiemi Cunha; SARAIVA-ROMANHOLO, Beatriz Mangueira; TIBERIO, Iolanda de Fatima Lopes CalvoObjective: To analyze whether resilience modulates the levels of depression, anxiety, stress and the impact of events in physiotherapists who work with COVID-19 patients with those who do not.Methods: A cross-sectional study was conducted from August 2020 up to October 2020. A total of 519 physiotherapists were enrolled and divided according to resilience and whether they worked with COVID-19 patients. Volunteers answered sociodemographic questionnaires, rating their depression, anxiety, and stress on a scale (DASS-21). The impact of event scale revised (IES-R) and 14-item resilience scale (14-RS) were also used.Results: Physiotherapists with low resilience present scores significantly high of depression, anxiety, stress and impact of event compared to the high resilience group (P < .001). Additionally, working with COVID-19 patients also resulted in increased levels of depression, anxiety, stress, and impact of event compared with the NO COVID19 group (P < .001). These responses were modulated by age, sex, number of absences from work, whether or not personal protective equipment was received, host leadership, and the practice and maintenance of regular physical activity.Limitations: The responses to the questionnaires were anonymous and self-administered. We cannot assess whether these people had a previous diagnosis of depression, anxiety and stress.Conclusions: Low resilience and work with COVID-19 patients were associated with high levels of depression, anxiety, and stress and worse psychological impacts of events. Several aspects modulate these responses and can contribute to improving the resilience and mental health of physiotherapists who are responsible for the care of COVID-19 patients.
- Resilience Improves the Quality of Life and Subjective Happiness of Physiotherapists during the COVID-19 Pandemic(2022) PIGATI, Patricia Angeli da Silva; RIGHETTI, Renato Fraga; DOURADO, Victor Zuniga; NISIAYMAMOTO, Bruna Tiemi Cunha; SARAIVA-ROMANHOLO, Beatriz Mangueira; TIBERIO, Iolanda de Fatima Lopes CalvoResilience is an individual characteristic that protects mental health. However, its impact on the lives of Brazilian physiotherapists during COVID-19 is not known. This study aimed to analyze whether resilience modulates the perceived quality of life (QoL) and subjective happiness (SH) of physiotherapists who work with COVID-19 patients, compared with those who do not. A cross-sectional study was conducted between 22 August and 22 October 2020. Physiotherapists working in critical and non-critical hospital sectors were invited to participate in the study. The participants completed sociodemographic questionnaires and were graded on the 14-item Resilience Scale, 36-item Short-Form Health Survey (SF-36), and the Subjective Happiness Scale. In total, 519 physiotherapists were enrolled in the study. Physiotherapists with low resilience who worked with COVID-19 patients reported lower scores on the SF-36 subscales (except for social functioning) and the Subjective Happiness Scale, compared with those with high resilience who did not work with COVID-19 patients. These responses were modulated by age, sex, absence from work, receipt of personal protective equipment, host leadership, and practice and maintenance of regular physical activity. In conclusion, physiotherapists with low resilience who worked with COVID-19 patients presented lower perceptions of QoL and SH, compared with the other study participants.
- Lung Mechanics Over the Century: From Bench to Bedside and Back to Bench(2022) BISELLI, Paolo Jose Cesare; LOPES, Fernanda Degobbi Tenorio Quirino Dos Santos; RIGHETTI, Renato Fraga; MORIYA, Henrique Takachi; TIBERIO, Iolanda Ftima Lopes Calvo; MARTINS, Milton ArrudaLung physiology research advanced significantly over the last 100 years. Respiratory mechanics applied to animal models of lung disease extended the knowledge of the workings of respiratory system. In human research, a better understanding of respiratory mechanics has contributed to development of mechanical ventilators. In this review, we explore the use of respiratory mechanics in basic science to investigate asthma and chronic obstructive pulmonary disease (COPD). We also discuss the use of lung mechanics in clinical care and its role on the development of modern mechanical ventilators. Additionally, we analyse some bench-developed technologies that are not in widespread use in the present but can become part of the clinical arsenal in the future. Finally, we explore some of the difficult questions that intensive care doctors still face when managing respiratory failure. Bringing back these questions to bench can help to solve them. Interaction between basic and translational science and human subject investigation can be very rewarding, as in the conceptualization of ""Lung Protective Ventilation"" principles. We expect this interaction to expand further generating new treatments and managing strategies for patients with respiratory disease.
- Airway inflammatory profile among cleaning workers from different workplaces(2022) PAZ, Edineia Rosa da; LIMA, Cynthia Mafra Fonseca de; FELIX, Soraia Nogueira; SCHAEFFER, Bruna; GALVAO, Clovis Eduardo Santos; CORREIA, Aristides Tadeu; RIGHETTI, Renato Fraga; MARTINS, Milton de Arruda; TIBERIO, Iolanda de Fatima Lopes Calvo; SARAIVA-ROMANHOLO, Beatriz MangueiraBackground Cleaning workers represent a significant proportion of the active population worldwide, with poor remuneration, particularly in developing countries. Despite this, they remain a relatively poorly studied occupational group. They are constantly exposed to agents that can cause symptoms and respiratory problems. This study aimed to evaluate upper airway inflammation in professional cleaning workers in three different occupational settings by comparing nasal cytology inflammation and clinical profiles. Methods We performed a cross-sectional study on the prevalence of upper airway inflammation and symptoms of asthma/rhinitis related to cleaning work, according to workplace. A total of 167 participants were divided into four groups: hospital, university, housekeeper and control. A nasal swab was collected for upper airway inflammation evaluation. Clinical profiles and respiratory symptom employee evaluations were performed using specific questionnaires (European Community Respiratory Health Survey-ECRS and the International Study of Asthma and Allergies in Childhood-ISAAC). Results Cleaning workers showed increased neutrophils and lymphocytes; the hospital and university groups showed increased macrophages compared to the housekeeper and control groups. The hospital and housekeeper groups showed increased eosinophils when they performed cleaning services for up to one year and reported having more asthma symptoms than the control group. Cleaning workers showed increased rhinitis symptoms. The university group showed increased rhinitis symptoms aggravated by the workplace compared with the hospital and housekeeper groups. Cleaning workers showed an increased affirmative response when directly asked about rhinitis symptoms compared to the control group. Conclusions Cleaning workers showed airway inflammation, asthma symptoms and rhinitis, regardless of the occupational environment to which they were exposed, as well as showed increased rhinitis and asthma symptoms. Hospital cleaning workers showed increased macrophages, lymphocytes and eosinophils compared to the others. The length of time spent performing cleaning work was not related to nasal inflammation or respiratory symptoms in this population. However, there were differences in workplaces. Registered on ClinicalTrials.gov. Trial registration number: NCT03311048. Registration date: 10.16.2017. Retrospectively registered.
conferenceObject Anti-IL-17 Treatment Modulates Pulmonary Responses in Model of Asthma-COPD Overlap(2022) CAMARGO, L.; SANTOS, T.; FUKUZAKI, S.; MARTINS, N.; ALMEIDA, F.; LOURENCO, J.; BEZERRA, S.; SARAIVA-ROMANHOLO, B.; PRADO, C.; LOPES, F.; LEICK, E.; RIGHETTI, R.; TIBERIO, I.- Effects of Air Pollution in S($)over-tilde-$ao Paulo on Asthma and COPD symptoms(2022) ALMEIDA, F. M.; MOREIRA, T. C. L.; OLIVEIRA, L. M.; RIGHETTI, R. F.; LOPES, F. D. T. Q. S.; ALENCAR, A. P.; MAUAD, T.; GOUVEIA, N. C.; LOTUFO, P. A.; BENSENOR, I.; SANTOS, I. S.; TIBERIO, I. F. L. C.