CAIO DE ASSIS MOURA TAVARES
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/65, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject The Peguero-Lo Presti criteria has the highest diagnostic accuracy for the diagnosis of left ventricular hypertrophy in the elderly(2020) TAVARES, C. A. M.; SAMESIMA, N.; HAJJAR, L. A.; GODOY, L. C.; HIRANO, E. M. P.; FACIN, M.; JACOB FILHO, W.; FARKOUH, M. E.; PASTORE, C. A.- Weighing Coronary Revascularization Options in Patients With Type 2 Diabetes Mellitus(2020) GODOY, Lucas C.; TAVARES, Caio A. M.; FARKOUH, Michael E.Patients with diabetes mellitus (DM) are at increased risk for developing coronary artery disease. Choosing the optimal revascularization strategy, such as coronary artery bypass grafting or percutaneous coronary intervention (PCI), may be difficult in this population. A large body of evidence suggests that, for patients with DM and stable multivessel ischemic heart disease, coronary artery bypass grafting is usually superior to PCI, leading to lower rates of all-cause mortality, myocardial infarction and repeat revascularization in the long term. In patients with less complex coronary anatomy (2- or single-vessel disease, especially without involvement of the proximal left anterior descendent artery), PCI may be a viable option. Because these anatomic patterns are less frequent in patients with DM, there is less evidence to guide revascularization in these cases. Patients with DM and left main disease and those in the acute coronary syndrome setting are also underrepresented in randomized trials, and the best revascularization strategy for these patients is not clear. Once the revascularization procedure is performed, patients should be kept engaged in controlling the risk factors for progression of cardiovascular disease. Avoidance of smoking, control of cholesterol, blood pressure and glycemic levels; regular practice of physical activity of at least moderate intensity; and a balanced diet are of key importance in the post-revascularization period. In this study, we review the current literature in the management of patients with DM and coronary artery disease undergoing a revascularization procedure. (C) 2019 Canadian Diabetes Association.
- Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity(2020) TAVARES, Caio A. M.; BAILEY, Matthew A.; GIRARDI, Adriana C. C.The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a public health crisis of major proportions. Advanced age, male gender, and the presence of comorbidities have emerged as risk factors for severe illness or death from COVID-19 in observation studies. Hypertension is one of the most common comorbidities in patients with COVID-19. Indeed, hypertension has been shown to be associated with increased risk for mortality, acute respiratory distress syndrome, need for intensive care unit admission, and disease progression in COVID-19 patients. However, up to the present time, the precise mechanisms of how hypertension may lead to the more severe manifestations of disease in patients with COVID-19 remains unknown. This review aims to present the biological plausibility linking hypertension and higher risk for COVID-19 severity. Emphasis is given to the role of the renin-angiotensin system and its inhibitors, given the crucial role that this system plays in both viral transmissibility and the pathophysiology of arterial hypertension. We also describe the importance of the immune system, which is dysregulated in hypertension and SARS-CoV-2 infection, and the potential involvement of the multifunctional enzyme dipeptidyl peptidase 4 (DPP4), that, in addition to the angiotensin-converting enzyme 2 (ACE2), may contribute to the SARS-CoV-2 entrance into target cells. The role of hemodynamic changes in hypertension that might aggravate myocardial injury in the setting of COVID-19, including endothelial dysfunction, arterial stiffness, and left ventricle hypertrophy, are also discussed.
- ACE2 Expression and Risk Factors for COVID-19 Severity in Patients with Advanced Age(2020) TAVARES, Caio de Assis Moura; AVELINO-SILVA, Thiago Junqueira; BENARD, Gil; CARDOZO, Francisco Akira Malta; FERNANDES, Juliana Ruiz; GIRARDI, Adriana Castello Costa; JACOB FILHO, Wilson
- The Evolving Landscape of the Geriatric Cardiology Field in Brazil: New Challenges for a New World(2020) TAVARES, Caio de Assis Moura; CAVALCANTI, Andre Feitosa Wanderley; JACOB FILHO, Wilson