WELLINGSON SILVA PAIVA

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: ALMIR FERREIRA DE ANDRADE × Assunto: Critical Care Medicine ×

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Agora exibindo 1 - 10 de 10
  • conferenceObject
    CORRELATION BETWEEN CHANGES IN GREY AND WHITE MATTER RADIODENSITY WITH PROGNOSIS AFTER CRANIOPLASTY
    (2014) OLIVEIRA, Arthur Maynart Pereira; AMORIM, Robson Luis Oliveira de; PAIVA, Wellingson Silva; ANDRADE, Almir Ferreira de; PASCHOAL JUNIOR, Fernando Mendes; BOR-SENG-SHU, Edson; COELHO, Fernanda; GATTAS, Gabriel Scarabotolo; ANGHINAH, Renato; TEIXEIRA, Manoel Jacobsen
  • conferenceObject
    CORRELATION BETWEEN INTRACRANIAL PRESSURE AND MEASUREMENT OF OPTIC NERVE SHEATH IN A SWINE MODEL OF INTRACRANIAL HYPERTENSION
    (2014) JEMG, Robson Luis Amorim Brasil Ping; ANDRADE, Almir Ferreira de; PAIVA, Wellingson Silva; BELON, Alessandro R.; OLIVEIRA, Marcelo Lima de; AZEVEDO, Maira; BOR-SENG-SHU, Edson; FIGUEIREDO, Eberval Gadelha; OTOCH, Jose Pinhata; TEIXEIRA, Manoel Jacobsen
  • conferenceObject
    MORPHOLOGICAL CHANGES ON CORTICAL SURFACE AND THEIR CORRELATION OF WITH NEUROLOGICAL OUTCOME IN PATIENTS WITH BONE DEFECTS AFTER DECOMPRESSIVE CRANIECTOMY
    (2014) OLIVEIRA, Arthur Maynart Pereira; AMORIM, Robson Luis Oliveira de; PAIVA, Wellingson Silva; ANDRADE, Almir Ferreira de; PASCHOAL JUNIOR, Fernando Mendes; BOR-SENG-SHU, Edson; COELHO, Fernanda; GATTAS, Gabriel Scarabotolo; ANGHINAH, Renato; TEIXEIRA, Manoel Jacobsen
  • conferenceObject
    WHAT CAN WE REALLY EXPECT OF CEREBRAL BLOOD FLOW AFTER CRANIOPLASTY?
    (2014) OLIVEIRA, Arthur Maynart Pereira; AMORIM, Robson Luis Oliveira de; PAIVA, Wellingson Silva; ANDRADE, Almir Ferreira de; PASCHOAL JUNIOR, Fernando Mendes; BOR-SENG-SHU, Edson; COELHO, Fernanda; GATTAS, Gabriel Scarabotolo; ANGHINAH, Renato; TEIXEIRA, Manoel Jacobsen
  • article 9 Citação(ões) na Scopus
    Traumatic pseudoaneurysm of the superior cerebellar artery
    (2012) PAIVA, Wellingson Silva; ANDRADE, Almir Ferreira; STERMAN NETO, Hugo; AMORIM, Robson Luis Oliveira de; CALDAS, Jose Guilherme; TEIXEIRA, Manoel Jacobsen
  • article 6 Citação(ões) na Scopus
    Inflammatory markers assessment in an animal model of intracranial hypertension: a randomized trial
    (2021) SANTO, Marcelo Prudente do Espirito; FARIA, Caroline Silverio; SOLLA, Davi Jorge Fontoura; PIPEK, Leonardo Zumerkorn; BELON, Alessandro Rodrigo; JENG, Brasil Ping; ANDRADE, Almir Ferreira de; TEIXEIRA, Manoel Jacobsen; PAIVA, Wellingson Silva
    Background: Intracranial hypertension (ICH) is a common final pathway of most neurosurgical pathologies and leads to poor prognosis if not detected and treated properly. Inflammatory markers have been assessed in clinical scenarios of neurological injuries, in which systemic and brain tissue aggressions may introduce bias. There is a lack of studies under controlled settings to isolate the ICH effect on inflammation. This study aims to evaluate the effects of ICH on the serum concentration of cytokines as biomarkers of neuroinflammation in an experimental model which isolates ICH from potential confounding variables. Methods: An established model of ICH using an intracerebral pediatric bladder catheter and a multisensor intraparenchymal catheter was used in adult pigs (Sus domesticus). The animals were randomly allocated to 2 groups based on the catheter balloon volume used to simulate the ICP increase (4 ml or 7 ml). Cytokines were measured in 4 timepoints during the experiment: (1) 15 min before balloon insufflation; (2) 5 min after insufflation; (3) 125 min after insufflation; (4) 60 min after deflation. The following cytokines were measured IL-1 alpha; IL-1 beta; IL-1ra; IL-2; IL-4; IL-6; IL-8; IL-10; IL-12; IL-18; TNFa. Generalized estimating equations were modeled to compare the ICP and cytokines values between the groups along the experiment. The study sample size was powered to detect interactions between the groups and the study moments with an effect size (f) of at least 0.3. The ARRIVE checklist was followed. Results: A total of 20 animals were studied (10 in each group, 4 ml or 7 ml balloon volume insufflation). The animal model was successful in increasing the ICP along the moments of the experiment (p < 0,001) and in creating an ICP gradient between the groups (p = 0,004). The interaction term (moment x group) was also significant (p < 0,001). There was a significant association between ICP elevation and most cytokines variation. The cytokines IL-1 alpha, IL-1 beta, IL1-ra, IL-6, IL-12, and IL-18 increased, whereas IL-2, IL-4, and TNF-alpha decreased. IL-10 did not vary significantly in response to the ICP elevation. Conclusion: The serum concentration of cytokines varied in response to intracranial hypertension. The study demonstrated the specific changes in each cytokine afterintracranial hypertension and provides key information to guide neuroinflammation clinical research. The proposed experiment was successful as an animal model to the study of neuroinflammation biomarkers.
  • conferenceObject
    CORRELATION BETWEEN INTRACRANIAL PRESSURE AND MEASUREMENT OF OPTIC NERVE SHEATH IN A SWINE MODEL OF INTRACRANIAL HYPERTENSION
    (2014) JEMG, Robson Luis Amorim Brasil Ping; ANDRADE, Almir Ferreira de; PAIVA, Wellingson Silva; BELON, Alessandro R.; OLIVEIRA, Marcelo Lima de; AZEVEDO, Maira; BOR-SENG-SHU, Edson; FIGUEIREDO, Eberval Gadelha; OTOCH, Jose Pinhata; TEIXEIRA, Manoel Jacobsen
  • article 10 Citação(ões) na Scopus
    Incremental Prognostic Value of Coagulopathy in Addition to the Crash Score in Traumatic Brain Injury Patients
    (2021) SOLLA, Davi J. Fontoura; AMORIM, Robson Luis Oliveira de; KOLIAS, Angelos G.; HUTCHINSON, Peter J.; ANDRADE, Almir Ferreira de; TEIXEIRA, Manoel Jacobsen; PAIVA, Wellingson Silva
    Background/objective Multivariable prognostic scores play an important role for clinical decision-making, information giving to patients/relatives, benchmarking and guiding clinical trial design. Coagulopathy has been implicated on trauma and critical care outcomes, but few studies have evaluated its role on traumatic brain injury (TBI) outcomes. Our objective was to verify the incremental prognostic value of routine coagulopathy parameters in addition to the CRASH-CT score to predict 14-day mortality in TBI patients. Methods This is a prospective cohort of consecutive TBI patients admitted to a tertiary university hospital Trauma intensive care unit (ICU) from March/2012 to January/2015. The prognostic performance of the coagulation parameters platelet count, prothrombin time (international normalized ratio, INR) and activated partial thromboplastin time (aPTT) ratio was assessed through logistic regression adjusted for the original CRASH-CT score. A new model, CRASH-CT-Coag, was created and its calibration (Brier scores and Hosmer-Lemeshow (H-L) test), discrimination [area under the receiver operating characteristic curve (AUC-ROC) and the integrated discrimination improvement (IDI)] and clinical utility (net reclassification index) were compared to the original CRASH-CT score. Results A total 517 patients were included (median age 39 years, 85.1% male, median admission glasgow coma scale 8, neurosurgery on 44.9%). The 14-day mortality observed and predicted by the original CRASH-CT was 22.8% and 26.2%, respectively. Platelet count < 100,000/mm(3), INR > 1.2 and aPTT ratio > 1.2 were present on 11.3%, 65.0% and 27.2%, respectively, (at least one of these was altered on 70.6%). All three variables maintained statistical significance after adjustment for the CRASH-CT score. The CRASH-CT-Coag score outperformed the original score on calibration (brier scores 0.122 +/- 0.216 vs 0.132 +/- 0.202, mean difference 0.010, 95% CI 0.005-0.019, p = 0.036, respectively) and discrimination (AUC-ROC 0.854 +/- 0.020 vs 0.813 +/- 0.024, p = 0.014; IDI 5.0%, 95% CI 1.3-11.0%). Both scores showed the satisfactory H-L test results. The net reclassification index favored the new model. Considering the strata of low (< 10%), moderate (10-30%) and high (> 30%) risk of death, the CRASH-CT-Coag model yielded a global net correct reclassification of 22.9% (95% CI 3.8-43.4%). Conclusions The addition of early markers of coagulopathy-platelet count, INR and aPTT ratio-to the CRASH-CT score increased its accuracy. Additional studies are required to externally validate this finding and further investigate the coagulopathy role on TBI outcomes.
  • conferenceObject
    EARLY SURGERY FOR FRONTAL DEPRESSED SKULL FRACTURE IS NOT ASSOCIATED WITH BETTER OUTCOME
    (2014) NEVILLE, Iuri S.; AMORIM, Robson Luis Oliveira de; PAIVA, Wellingson Silva; SANDERS, Felipe Hada; SILVA, Vinicius Trindade Gomes da; MENENDEZ, Djalma Felipe S.; ANDRADE, Almir Ferreira de
  • conferenceObject
    INTRACRANIAL HYPERTENSION MODEL IN PIGS: ASSESSMENT WITH TRANSCRANIAL DOPPLER AND INTRACRANIAL PRESSURE MONITORING
    (2014) ANDRADE, Almir Ferreira de; MATHEUS, S.; PATRIOTA, Gustavo C.; BELON, Alessandro; PAIVA, Wellingson S.; JENG, Brasil P.; BOR-SENG-SHU, Edson; OLIVEIRA, Marcelo; NASCIMENTO, Clarissa; AMORIM, Robson; FIGUEIREDO, Eberval G.; OTOCH, Jose P.; TEIXEIRA, Manoel J.