DEWTON DE MORAES VASCONCELOS
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
conferenceObject Primary Immunodeficiency Disorders (PID) in a Specialized Dermatology Outpatient Unit in Sao Paulo, Brazil(2014) VASCONCELOS, D. Moraes; DOMINGUES-FERREIRA, M.; CHUFFI-BARROS, N.; BEZERRA, T. A.; BERTOLINI, D. L.; MUNIZ JUNIOR, R.; PRESTES-CARNEIRO, L. E.; DUARTE, A. J.- Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis(2017) DOMINGUES-FERREIRA, Mauricio; LEVY, Ariel; BARROS, Noac Chuffi; BERTOLINI, Dalton Luis; VASCONCELOS, Dewton de MoraesMyeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis.
- Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature(2021) VASCONCELOS, Dewton de Moraes; BERTOLINI, Dalton Luis; FERREIRA, Mauricio DominguesWe describe the first report of a patient with chronic mucocutaneous candidiasis associated with disseminated and recurrent paracoccidioidomycosis. The investigation demonstrated that the patient had a mannose receptor deficiency, which would explain the patient's susceptibility to chronic infection by Candida spp. and systemic infection by paracoccidioidomycosis. Mannose receptors are responsible for an important link between macrophages and fungal cells during phagocytosis. Deficiency of this receptor could explain the susceptibility to both fungal species, suggesting the impediment of the phagocytosis of these fungi in our patient.
- Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency?(2017) FERREIRA, Mauricio Domingues; COLLANIERE, Anna Cristina; BERTOLINI, Dalton Luis; BARROS, Noac Chuffi; VASCONCELOS, Dewton de MoraesHere, we describe a case of hepatosplenic schistosomiasis that progressed to widespread persistent dermatophytosis. Significant T and B lymphocytopenia was confirmed. T-cell deficit is associated with increased susceptibility to fungal infections of skin and mucous membranes. The accumulation of a large amount of blood cells in the spleen could have played a crucial role in the development of lymphocytopenia in the present case. Alternatively, the schistosomiasis-induced increase in prostaglandin E2 levels could have inhibited the production of interferon-gamma, a cytokine fundamental to fungal resistance. This case shows the potential of hepatosplenic schistosomiasis to impair the immune response.
conferenceObject APECED AUTOIMMUNE POLYENDOCRINOPATHY WITH CANDIDIASIS AND ECTODERMAL DYSTROPHY AND ESOPHAGEAL RUPTURE BY CANDIDIASIS IMMUNODEFICIENCY(2016) BERTOLINI, Dalton Luis; MORAES-VASCONCELOS, Dewton; DOMINGUES-FERREIRA, Mauricio; BEZERRA, Thiago de AlmeidaconferenceObject Hereditary Angioedema: Report of 68 Cases(2014) GRUMACH, A. S.; DOMINGUES-FERREIRA, M.; CHUFFI-BARROS, N.; BEZERRA, T. A.; BERTOLINI, D. L.; MUNIZ JUNIOR, R.; PRESTES-CARNEIRO, L. E.; DUARTE, A. J.; VASCONCELOS, D. Moraes- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and esophageal rupture by candida infection: A case report and review(2022) DOMINGUES-FERREIRA, Mauricio; VASCONCELOS, Dewton de Moraes; BEZERRA, Thiago de Almeida; BERTOLINI, Dalton Luis; BARROS, Noac Chuffi; AULER, Marcos ErenoWe probably describe the first report of esophageal rupture in a patient with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED, OMIM # 240300), who had candida esophagitis as the main feature for decades. Strong evidence shows that this rupture may have been caused directly and indirectly by chronic candidiasis. In this way, we demonstrate how severe and harmful the persistent esophageal candidiasis can cause in the esophagus, especially in immunodeficient patients.