DEWTON DE MORAES VASCONCELOS
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
- Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis(2017) DOMINGUES-FERREIRA, Mauricio; LEVY, Ariel; BARROS, Noac Chuffi; BERTOLINI, Dalton Luis; VASCONCELOS, Dewton de MoraesMyeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis.
- Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency?(2017) FERREIRA, Mauricio Domingues; COLLANIERE, Anna Cristina; BERTOLINI, Dalton Luis; BARROS, Noac Chuffi; VASCONCELOS, Dewton de MoraesHere, we describe a case of hepatosplenic schistosomiasis that progressed to widespread persistent dermatophytosis. Significant T and B lymphocytopenia was confirmed. T-cell deficit is associated with increased susceptibility to fungal infections of skin and mucous membranes. The accumulation of a large amount of blood cells in the spleen could have played a crucial role in the development of lymphocytopenia in the present case. Alternatively, the schistosomiasis-induced increase in prostaglandin E2 levels could have inhibited the production of interferon-gamma, a cytokine fundamental to fungal resistance. This case shows the potential of hepatosplenic schistosomiasis to impair the immune response.
- Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease in a Single Institution in Brazil. Reproducing Good Results with a Reduced Toxicity Regimen(2017) FERNANDES, Juliana Folloni; MANTOVANI, Luiz Fernando Alves Lima; VENANCIO, Angela Mandelli; DORNA, Mayra; PASTORINO, Antonio Carlos; VASCONCELOS, Dewton; NETO, Antonio Condino; MOURA, Ana Carla Augusto; COLLASSANTI, Maria Dulce; ZANICHELLI, Maria Aparecida; CARNEIRO-SAMPAIO, Magda; ROCHA, Vanderson G.; ODONE FILHO, Vicente
- II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies(2017) GOUDOURIS, Ekaterini Simões; SILVA, Almerinda Maria do Rego; OURICURI, Aluce Loureiro; GRUMACH, Anete Sevciovic; CONDINO-NETO, Antonio; COSTA-CARVALHO, Beatriz Tavares; PRANDO, Carolina Cardoso de Mello; KOKRON, Cristina Maria; VASCONCELOS, Dewton de Moraes; TAVARES, Fabíola Scancetti; SEGUNDO, Gesmar Rodrigues Silva; BARRETO, Irma Cecília Douglas Paes; DORNA, Mayra de Barros; BARROS, Myrthes Anna Maragna Toledo; FORTE, Wilma Carvalho NevesABSTRACT In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published in 2010. The document presents new knowledge about the indications and efficacy of immunoglobulin therapy in primary immunodeficiencies, relevant production-related aspects, mode of use (routes of administration, pharmacokinetics, doses and intervals), adverse events (major, prevention, treatment and reporting), patient monitoring, presentations available and how to have access to this therapeutic resource in Brazil.
- Role of T. cruzi exposure in the pattern of T cell cytokines among chronically infected HIV and Chagas disease patients(2017) TOZETTO-MENDOZA, Tania Regina; VASCONCELOS, Dewton de Moraes; IBRAHIM, Karim Yaqub; SARTORI, Ana Marli Christovam; BEZERRA, Rita C.; FREITAS, Vera Lucia Teixeira de; SHIKANAI-YASUDA, Maria AparecidaOBJECTIVES: The impact of Chagas disease (CD) in HIV-infected patients is relevant throughout the world. In fact, the characterization of the adaptive immune response in the context of co-infection is important for predicting the need for interventions in areas in which HIV and Chagas disease co-exist. METHODS: We described and compared the frequency of cytokine-producing T cells stimulated with soluble antigen of Trypanosoma cruzi (T. cruzi) using a cytometric assay for the following groups: individuals with chronic Chagas disease (CHR, n=10), those with Chagas disease and HIV infection (CO, n=11), those with only HIV (HIV, n=14) and healthy individuals (C, n=15). RESULTS: We found 1) a constitutively lower frequency of IL-2+ and IFN-gamma+T cells in the CHR group compared with the HIV, CO and healthy groups; 2) a suppressive activity of soluble T. cruzi antigen, which down-regulated IL-2+CD4+ and IFN-gamma+ CD4+ phenotypes, notably in the healthy group; 3) a down-regulation of inflammatory cytokines on CD8+ T cells in the indeterminate form of Chagas disease; and 4) a significant increase in IL-10 + CD8+ cells distinguishing the indeterminate form from the cardiac/digestive form of Chagas disease, even in the presence of HIV infection. CONCLUSIONS: Taken together, our data suggest the presence of an immunoregulatory response in chronic Chagas disease, which seems to be driven by T. cruzi antigens. Our findings provide new insights into immunotherapeutic strategies for people living with HIV/AIDS and Chagas disease.
- Comment to: II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies. einstein (Sao Paulo). 2017; 15(1): 1-16(2017) GOUDOURIS, Ekaterini Simoes; SILVA, Almerinda Maria do Rego; OURICURI, Aluce Loureiro; GRUMACH, Anete Sevciovic; CONDINO-NETO, Antonio; COSTA-CARVALHO, Beatriz Tavares; PRANDO, Carolina Cardoso de Mello; KOKRON, Cristina Maria; VASCONCELOS, Dewton de Moraes; TAVARES, Fabiola Scancetti; SEGUNDO, Gesmar Rodrigues Silva; BARRETO, Irma Cecilia Douglas Paes; DORNA, Mayra de Barros; BARROS, Myrthes Anna Maragna Toledo; FORTE, Wilma Carvalho Neves
conferenceObject EVALUATION OF ANTIVIRAL IMMUNITY IN NASAL WASH OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY ALONG WITH VIRAL RHINOSINUSITIS.(2017) BEZERRA, Thiago de Almeida; MORAES-VASCONCELOS, Dewton de; PONTILLO, Alessandra; DUARTE, Alberto Jose da Silva; MACHADO, Clarisse Martins; VOAS, Lucy Santos Vilas- II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies (vol 15, pg 1, 2017)(2017) GOUDOURIS, Ekaterini Simoes; SILVA, Almerinda Maria do Rego; OURICURI, Aluce Loureiro; GRUMACH, Anete Sevciovic; CONDINO-NETO, Antonio; COSTA-CARVALHO, Beatriz Tavares; PRANDO, Carolina Cardoso de Mello; KOKRON, Cristina Maria; VASCONCELOS, Dewton de Moraes; TAVARES, Fabiola Scancetti; SEGUNDO, Gesmar Rodrigues Silva; BARRETO, Irma Cecelia Douglas Paes; SEGUNDO, Gesmar Rodrigues Silva; BARRETO, Irma Cecelia Douglas Paes; BARROS, Myrthes Anna Maragna Toledo; DORNA, Mayra de Barros; FORTE, Wilma Carvalho Neves