JOSE OTTO REUSING JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
conferenceObject IS CMV PROPHYLAXIS EFFECTIVE IN CMV-SEROPOSITIVE PATIENTS RECEIVING THYMOGLOBULIN AS INDUCTION THERAPY?(2017) REUSING JUNIOR, Jose Otto; FEITOSA, Emanoela Batista; PIERROTI, Ligia; AGENA, Fabiana; AZEVEDO, Luiz Sergio; DAVID-NETO, Elias- COVID-19 among kidney-transplant recipients requiring hospitalization: preliminary data and outcomes from a single-center in Brazil(2020) PIERROTTI, Ligia Camera; REUSING JUNIOR, Jose Otto; FREIRE, Maristela Pinheiro; MACHADO, David J. Barros; MOREIRA, Raquel Megale; VENTURA, Carlucci G.; LITVOC, Marcelo Nobrega; NAHAS, William C.; DAVID-NETO, Elias
conferenceObject Prediction Model With Quantiferon-CMV for Clinically Significant Cytomegalovirus Event in Seropositive Kidney Transplant Recipients(2022) REUSING JUNIOR, Jose Otto; AGENA, Fabiana; CAMPANA, Gustavo A.; PIERROTTI, Ligia C.; DAVID-NETO, EliasconferenceObject Case Report: Nephrotic-Range Proteinuria in a Deceased Donor Recipient With Acute Antibody Mediated Rejection And Familiar FSGS(2022) ALBUQUERQUE, Claudia C. C.; GAZOLLA, Daniel N.; REUSING JUNIOR, Jose Otto- Performance of two methods of carbapenem-resistant Enterobacterales surveillance on a kidney transplant ward: selective culture of and real-time PCR directly from rectal swabs(2022) FREIRE, Maristela P.; GARCIA, Doroti de Oliveira; LIMA, Stephanie Garcia; PEA, Claudia Regina Delafiori; REUSING JUNIOR, Jose Otto; SPADAO, Fernanda; CURY, Ana Paula; ROSSI, Flavia; NAHAS, William C.; DAVID-NETO, Elias; PIERROTTI, Ligia C.Background Infection with carbapenem-resistant Enterobacterales (CRE) is associated with a high mortality rate in kidney transplant recipients, and colonization with CRE is one of the major risk factors for CRE infection. There is, therefore, a need to improve the capacity to detect colonization with CRE among inpatients. Methods In this prospective study, we compared the performance of real-time PCR for carbapenemase directly from rectal swabs with that of conventional CRE surveillance culture in all patients admitted to a kidney transplant ward between February 2019 and March 2020. Surveillance culture and real-time PCR were performed at admission and weekly until hospital discharge. Two perineum-rectal swabs were collected: one for culture and one for PCR. Results We collected 905 paired samples for CRE surveillance from 399 patients, of whom 347 (87.0%) were kidney transplant recipients and 52 were waiting list patients. CRE was detected by culture and/or PCR in 75 patients (18.8%). Positivity for CRE was identified by PCR in 62 (15.5%) of the 399 patients and by culture in 55 (13.8%); 20 (5.0%) of the patients tested positive only on PCR, and 13 (3.3%) tested positive only on culture. The most common carbapenemase and species were, respectively, bla(KPC) (in 85.5%) and Klebsiella pneumoniae (in 80.0%). Infection with CRE occurred in 21.6% of the colonized patients, those cases occurred only among kidney transplant recipients. None of the patients who tested negative on culture developed CRE infection. Conclusion In conclusion, the two methods are complementary and could be useful in a scenario of high CRE prevalence.