JOSE OTTO REUSING JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
16 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 16
- Prioritization Due to Dialysis Access Failure Impacts on Patient Survival after Kidney Transplantation(2013) REUSING JR., J.; SOUZA, P.; GALANTE, N.; AGENA, F.; PAULA, F. de; NAHAS, W.; DAVID-NETO, E.Dialysis vascular access failure, recipient of a non-renal solid organ transplantation and previous kidney donation are current indications of priority allocation (PA) for kidney transplant (KT) at our centre. Mortality among PA patients under dialysis is high and risk factors for long-term patient outcomes after transplantation remain largely elusive. In this study we analyzed a cohort of patients that received KT from Jan/2007 to Dec/2011. Long-term patient survival was compared between PA and non PA recipients transplanted in this period of time and clinical relevant data were analyzed. Data were recorded as of Aug/2012. Results: 948 KT were performed at our institution and 93 (9.8%) were included in our PA program. Most PA patients (n=86) had access failure. The mean follow up time was 32 (0 – 69) months. 5-year patient survival was lower in PA patients (76vs 86%, p=0.001). Twenty (21.5%) PA patients died and all deaths occurred in those with access failure, being 70% of them in the first 3 months. Causes of death were infection in 10 patients, bleeding complications (n=6), uremia (n=1), mesenteric ischemia (n=1) and unspecified shock (n=2). Considering this high mortality rate in the first 3 months after transplantation, we compared patients who died in this period of time (group A) vs. those who survived more than 3 months (group B). Age, gender, previous kidney transplants, sensitization, number of HLA mismatches, pre-transplant DSA, pre-transplant diabetes, induction therapy, DGF, rejection, use of heparin, IVIg and time from inscription in the PA program to transplantation were not statistically different between groups. Among 47 patients who were screened for thrombophilia, 83.3% from group A were positive vs. 31.7% from group B (p=0.01). Infection after transplantation and hemorrhagic complications were more frequent in group A. Groups were not different regarding causes of death. PA patients have a lower survival and this excessive death rate occur in the first three months after transplantation mainly due to infections and bleeding. Thrombophilia is very frequent in PA patients with HR....... for death.
conferenceObject Fast Decrease of Humoral Response Against SARS-CoV-2 in A Kidney Transplant Cohort(2022) COSTA, Gisela Serra Rodrigues; MIRANDA, Lara Judith Cabral; BRINGEL, Eric Arcanjo; OTTO, Jose Junior; CENEVIVA, Carina; CORA, Aline Pivetta; SILVA, Luciane Carvalho Sarahyba; DIAS, Claudia Maria Meira; UDILOFF, Patricia Alves Santos; DAVID-NETO, Elias; PIERROTTI, Ligia CameraconferenceObject TRANSPLANTABILITY EVALUATION IN HIGH RISK PATIENTS WITH END STAGE RENAL DISEASE ENROLLED IN THE WAITING LIST OF KIDNEY TRANSPLANTATION. AN OBSERVATIONAL COHORT STUDY(2017) IZQUIERDO, Andrea Andrade; ONUSIC, Vivian L.; OTTO JR., Jose; LEMOS, Francine Bc; PAULA, Flavio J. De; NAHAS, William C.; DAVID-NETO, EliasconferenceObject Is 90-days CMV prophylaxis effective in CMV-seropositive patients receiving thymoglobulin as induction therapy?(2016) DAVID-NETO, Elias; FEITOSA, Emanoela B.; AGENA, Fabiana; REUSING, Jose Otto; LEMOS, Francine B. C.- Association Between Total Cell Free DNA and SARS-CoV-2 In Kidney Transplant Patients: A Preliminary Study(2022) JR, Jose Otto Reusing; YOO, Jongwon; DESAI, Amishi; BROSSART, Katya; MCCORMICK, Sarah; MALASHEVICH, Allyson Koyen; BLOOM, Michelle S.; FEHRINGER, Gordon; WHITE, Roseann; BILLINGS, Paul R.; TABRIZIANI, Hossein; DEMKO, Zachary P.; GAUTHIER, Philippe; AKKINA, Sanjeev K.; DAVID-NETO, EliasBackground. Kidney transplant (KT) recipients are at high risk for developing severe COVID-19. Lowering immunosuppression levels in KT recipients with COVID-19 encourages native immune responses but can raise the risk of rejection. Donor-derived cell-free DNA (dd-cfDNA), reported as a fraction of total cfDNA, is a proven biomarker for KT rejection. Total cfDNA levels are elevated in patients with COVID-19, which may depress dd-cfDNA fractions, potentially leading to missed rejections.Methods. A retrospective analysis of 29 KT recipients hospitalized with COVID-19 between April and November 2020 examined total and dd-cfDNA levels. Blood samples were collected after onset of COVID-19, with follow-up samples collected from a subset of patients, when infection had likely subsided.Results. After COVID-19 diagnosis, the median total cfDNA level was elevated (7.9 multiples of median [MoM]). A significant decrease in total cfDNA levels was observed between the first and second time points (6.2 MoM, 1.0 MoM; P <001). A significant positive association was identified between total cfDNA levels and COVID-19 severity (P = .02; R2 = .19). Two patients with biopsy -proven acute cellular rejection had dd-cfDNA fractions below the 1% cutoff for rejection (0.20% and 0.78%), with elevated total cfDNA levels of 7.9 MoM and 41.8 MoM, respectively.Conclusions. In this preliminary study, total cfDNA levels were elevated in KT patients with COVID-19, subsiding after resolution of infection. High total cfDNA levels may confound dd-cfDNA results, leading to failure to identify rejection. Considering total cfDNA levels is impor-tant in interpretation of dd-cfDNA tests for assessment of rejection in KT patients with COVID-19 or other infection.
conferenceObject IS CMV PROPHYLAXIS EFFECTIVE IN CMV-SEROPOSITIVE PATIENTS RECEIVING THYMOGLOBULIN AS INDUCTION THERAPY?(2017) REUSING JUNIOR, Jose Otto; FEITOSA, Emanoela Batista; PIERROTI, Ligia; AGENA, Fabiana; AZEVEDO, Luiz Sergio; DAVID-NETO, Elias- COVID-19 among kidney-transplant recipients requiring hospitalization: preliminary data and outcomes from a single-center in Brazil(2020) PIERROTTI, Ligia Camera; REUSING JUNIOR, Jose Otto; FREIRE, Maristela Pinheiro; MACHADO, David J. Barros; MOREIRA, Raquel Megale; VENTURA, Carlucci G.; LITVOC, Marcelo Nobrega; NAHAS, William C.; DAVID-NETO, Elias
conferenceObject THROMBOPHILIA AND PRIORITIZATION DUE TO DIALYSIS ACCESS FAILURE IMPACT EARLY ON PATIENT SURVIVAL AFTER KIDNEY TRANSPLANTATION(2013) REUSING JR., Jose O.; SOUZA, Patricia S.; GALANTE, Nelson Z.; AGENA, Fabiana; PAULA, Flavio J.; NAHAS, William Carlos; DAVID-NETO, EliasconferenceObject IMPACT OF EVEROLIMUS ADDED TO TACROLIMUS/MYCOPHENOLATE/ PREDNISONE ON CMV DISEASE AND ACUTE REJECTION IN SENSITIZED KIDNEY TRANSPLANT RECIPIENTS. A SINGLE CENTER, RANDOMIZED AND CONTROLLED, PILOT STUDY(2017) SOUZA, Patricia; VENTURA, Carlucci; AGENA, Fabiana; BARRETO, Noemia; REUSING, Jose Otto; ONUSIC, Vivian; ZOCOLER, Nelson; PAULA, Flavio De; DAVID-NETO, EliasconferenceObject Omicron COVID-19 in Kidney Transplant Recipients(2022) COSTA, Gisela Serra Rodrigues; REUSING, Jose Otto; FREIRE, Maristela Pinheiro; MOREIRA, Raquel Megale; LITVOC, Marcelo Nobrega; VENTURA, Carlucci; MACHADO, David; DAVID-NETO, Elias; PIERROTTI, Ligia Camera