MARCO DE TUBINO SCANAVINO

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Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/49 - Laboratório de Protozoologia, Hospital das Clínicas, Faculdade de Medicina

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  • article 8 Citação(ões) na Scopus
    The eleven-item Alcohol, Smoking and Substance Involvement Screening Test (ASSIST-11): Cross-cultural psychometric evaluation across 42 countries
    (2023) LEE, Chih-Ting; LIN, Chung-Ying; KOOS, Monika; NAGY, Lena; KRAUS, Shane W.; DEMETROVICS, Zsolt; POTENZA, Marc N.; BALLESTER-ARNAL, Rafael; BATTHYANY, Dominik; BERGERON, Sophie; BILLIEUX, Joel; BURKAUSKAS, Julius; CARDENAS-LOPEZ, Georgina; CARVALHO, Joana; CASTRO-CALVO, Jesus; CHEN, Lijun; CIOCCA, Giacomo; CORAZZA, Ornella; CSAKO, Rita I.; FERNANDEZ, David P.; FERNANDEZ, Elaine F.; FUJIWARA, Hironobu; FUSS, Johannes; GABRHELIK, Roman; GEWIRTZ-MEYDAN, Ateret; GJONESKA, Biljana; GOLA, Mateusz; GRUBBS, Joshua B.; HASHIM, Hashim T.; ISLAM, Md. Saiful; ISMAIL, Mustafa; JIMENEZ-MARTINEZ, Martha; JURIN, Tanja; KALINA, Ondrej; KLEIN, Verena; KOLTO, Andras; LEE, Sang-Kyu; LEWCZUK, Karol; LOCHNER, Christine; LOPEZ-ALVARADO, Silvia; LUKAVSKA, Katerina; MAYTA-TRISTAN, Percy; MILEA, Ionut; MILLER, Dan J.; OROSOVA, Olga; OROSZ, Gabor; TEAM, Fernando P. Sungkyunkwan Univ Res; PONCE, Fernando P.; QUINTANA, Gonzalo R.; GARZOLA, Gabriel C. Quintero; RAMOS-DIAZ, Jano; RIGAUD, Kevin; ROUSSEAU, Ann; SCANAVINO, Marco De Tubino; SCHULMEYER, Marion K.; SHARAN, Pratap; SHIBATA, Mami; SHOIB, Sheikh; SIGRE-LEIROS, Vera; SNIEWSKI, Luke; SPASOVSKI, Ognen; STEIBLIENE, Vesta; STEIN, Dan J.; STRIZEK, Julian; UNSAL, Berk C.; VAILLANCOURT-MOREL, Marie-Pier; HOUT, Marie Claire Van; BOTHE, Beata
    The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) is an instrument to screen substance -use-related health risks. However, little is known whether the ASSIST could be further shortened while remaining psychometrically sound across different countries, languages, gender identities, and sexual-orientation-based groups. The study aimed to validate a shortened 11-item ASSIST (ASSIST-11). Using the International Sex Sur-vey data, 82,243 participants (M age = 32.39 years) across 42 countries and 26 languages completed questions from the ASSIST-11 regarding gender identity, sexual orientation, and other information. Confirmatory factor analysis (CFA) and multigroup CFA (MGCFA) evaluated the ASSIST-11's structure and tested measurement invariance across groups. Cronbach's & alpha; and McDonald's & omega; were used to examine the internal consistency. Cohen's d and independent t-tests were used to examine known-group validity. The ASSIST-11 was unidimen-sional across countries, languages, age groups, gender identities (i.e., men, women, and gender-diverse in-dividuals), and sexual orientations (i.e., heterosexual and sexual minority individuals). Cronbach's & alpha; was 0.63 and McDonald's & omega; was 0.68 for the ASSIST-11. Known-group validity was supported by Cohen's d (range be-tween 0.23 and 0.40) with significant differences (p-values<0.001). The ASSIST-11 is a modified instrument with a unidimensional factor structure across different languages, age groups, countries, gender identities, and sexual orientations. The low internal consistency of the ASSIST-11 might be acceptable as it assesses a broad concept (i. e., use of several different substances). Healthcare providers and researchers may use the ASSIST-11 to quickly assess substance-use information from general populations and evaluate the need to follow up with more detailed questions about substance use.
  • article 2 Citação(ões) na Scopus
    Treatment effects and adherence of sexually compulsive men in a randomized controlled trial of psychotherapy and medication
    (2023) SCANAVINO, Marco D. T.; GUIRADO, Alia Garrudo; MARQUES, Joao Miguel; AMARAL, Maria Luiza Sant'Ana Do; MESSINA, Bruna; REIS, Sirlene Caramello Dos; BARROS, Vivian Boschesi; ABDO, Carmita Helena Najjar; TAVARES, Hermano; PARSONS, Jeffrey T.
    Background: Little attention has been given to efficacious treatment and adherence to treatment of compulsive sexual behavior (CSB). Aims: Randomized controlled trial investigated short-term psycho -dynamic group therapy followed by relapse prevention group (STPGP-RPGT) and pharmacological treatment (PT) for CSB men on sexual compulsivity and adherence. Method: 135 men, 38 (SD = 9) years old on average, were randomly assigned to 1) STPGP-RPGT; 2) PT; 3) Both. Participants completed measures at baseline, 25th, and 34th week. 57 (42.2%) participants dropped out between baseline and 25th week, and 68 (50.4%) between baseline and 34th week. 94 (69.6%) did not adhere (80% pills taken or attended 75% therapy sessions). Results: A significant interaction effect was found between time and group (F (4, 128) = 2.62, P = 0.038, ES = 0.08), showing who received PT improved less in sexual compulsivity than those who received STPGP-RPGT (t = 2.41; P = 0.038; ES = 0.60) and PT thorn STPGP-RPGT (t = 3.15; P = 0.007, ES = 0.74). Adherent participants improved more in sexual compulsivity than non-adherent at the 25th week (t = 2.82; P = 0.006, ES = 0.65) and 34th week (t = 2.26; P = 0.027, ES = 0.55), but there was no interaction effect, F (2, 130) = 2.88; P = 0.06; ES = 0.04). The most reported behavior (masturbation) showed greater risk of non-adherence (72.6%). Discussion and conclusions: Adherent participants improved better than non-adherent. Participants who received psychotherapy improved better than those who received PT. Methodological limitations preclude conclusions on efficacy.
  • article 17 Citação(ões) na Scopus
    Sexual Disorders and Quality of Life in Parkinson's Disease
    (2021) MALCHER, Claudia Marques Santa Rosa; OLIVEIRA, Kleber Roberto da Silva Goncalves; CALDATO, Milena Coelho Fernandes; LOBATO, Bruno Lopes dos Santos; PEDROSO, Janari da Silva; SCANAVINO, Marco de Tubino
    Introduction: Sexual disorders are the most neglected nonmotor symptoms in Parkinson's disease (PD). Although doctors seek greater priority to motor manifestations, which are the basis for the diagnosis of PD, the nonmotor symptoms deserve to be highlighted as much as the motor problems because of their strong presence and discomfort in the patients, causing the important impairment in the quality of life (QoL) of the individual with PD. Aim: Provide the prevalence of sexual disorders among patients with PD and alert the medical profession to investigate and be familiar with problems related to QoL and sexual disorders in PD. Methods: This is a large literature review on sexual disorders in PD and impaired QoL. Main Outcome Measures: Sexual disorders in PD and prevalence between genders have been described in epidemiological studies. Neuroanatomy, pathophysiology, risk factors, QoL, and etiologies were reviewed. Results: The estimate of the prevalence of sexual dysfunction in the form of compulsive sexual behavior in PD is higher in men by 5.2% than in women by 0.5%. This diagnosis is a determinant of intense and persistent suffering and is related to several health problems of a social, economic, personal, family, psychological, and occupational nature, which can even culminate in sexual abuse. It is most commonly associated with the use of drugs commonly used in PD therapy in 98.1% of cases. In addition to this serious public health problem, another common condition of sexual dysfunction occur with the decreased libido by loss of the neurotransmitter dopamine proper of the pathophysiology of PD. Conclusion: The presence of sexual disorders in PD should be tracked and monitored because of its harmful consequences, whether due to increased sexual behavior or associated psychological distress, as well as the impacts on QoL. Early recognition and adequate treatment of PD in its fullness and richness of associated symptoms are essential for improving QoL.
  • article 4 Citação(ões) na Scopus
    Sexual Dysfunctions Among People Living With HIV With Long- Term Treatment With Antiretroviral Therapy
    (2022) SCANAVINO, Marco De Tubino; MORI, Emi; NISIDA, Vera Vichr; AVELINO-SILVA, Vivian I.; AMARAL, Maria Luiza Sant'ana do; MESSINA, Bruna; SEGURADO, Aluisio Cotrim
    Introduction: Sexuality plays an essential role in the psychosocial well-being of people living with HIV (PLHIV) but it is still less assessed by healthcare professionals during treatment. Aim: To investigate the frequency of those screening positive for sexual dysfunction (SD) and associated factors according to gender/sexual orientation in PLHIV under long-term treatment with antiretroviral therapy (ART). Methods: Between September 2013 and October 2016, 234 PLHIV adults in treatment in Sao Paulo were included. Participants were sexually active, did not present sexual orientation disorder or body dysmorphicdisor-der, and did not use sexual hormones. We performed clinical interviews and measured levels of depression, anxiety, and levels of sexual hormones. SD was assessed using a self-report questionnaire. Main Outcome Measures: Proportion of participants screening positive for SD in the International Index of Erectile Function, the Index of Premature Ejaculation, and the Female Sexual Function Index. In the regression analyses, the outcome SD considered any SD presented with disregard to gender. Results: 70% of participants reported consistent adherence to ART and 96% had an undetectable viral load. The median (Md) duration of ART was 198 months (inter quartil range, IQR 111.6-230.4) and the median CD4 was 655 cells/mm(3) (IQR 443-871). Screening positive for erectile dysfunction was 49.7%, premature ejaculation 16.9%, female sexual dysfunction 27.4% and hypoactive desire 45.1%. Lower testosterone and prolactin levels were associated with erectile dysfunction in heterosexual men (n = 58); lower levels of oestradiol and higher levels of follicle stimulating hormone were associated with female sexual dysfunction and hypoactive desire in female participants (n = 63). The multivariable model used included comorbidities and hormonal abnormality and found that age (odds ratio, OR = 1.04, 95% confidence interval, 95%CI 1.00-1.08, P = .026) and the presence of depression/anxiety (OR = 2.96; 95%CI 1.52-5.77; P = .001) were associated with SD. Also, men reporting engaging in sex with other men were associated with screening positive for SD (OR 2.66; 95%CI 1.52-5.77, P = .013). During treatment of PLHIV, it is important to evaluate sexual health and symptoms of depression and anxiety specifically. The strength of this study consists in evaluating PLHIV who have been in long-term treatment with ART and analyzing those screening positive for SD and associated factors for each group (heterosexual men, men reporting engaging in sex with other men, and women). Limitation includes the difficulty to generalize the findings of the study, and not exploring women's sexual orientation. Conclusion: PLHIV in long-term treatment with ART presented alarming rates of depression/anxiety which in turn is correlated with sexual and physical health problems.
  • article 1 Citação(ões) na Scopus
    Symptoms of depression (not anxiety) mediate the relationship between childhood sexual abuse and compulsive sexual behaviors in men
    (2023) REIS, Sirlene C.; PARK, Katey E.; DIONNE, Michelle M.; KIM, Hyoun S.; SCANAVINO, Marco D. T.
    Objective: Childhood sexual abuse is associated with compulsive sexual behavior, depression, and anxiety in men. Furthermore, both depression and anxiety have been linked to compulsive sexual behaviors. However, whether anxiety and depression mediate the relationship between childhood sexual abuse and compulsive sexual behaviors has yet to be tested. We investigated whether symptoms of depression and anxiety mediate the relationship between childhood sexual abuse and compulsive sexual behaviors in 222 men seeking treatment for such behaviors. Methods: Participants completed the Sexual Compulsivity Scale, Childhood Trauma Questionnaire, Beck Depression Inventory, and Beck Anxiety Inventory. A cross-sectional parallel mediation analysis was conducted. Results: The prevalence of childhood sexual abuse in our sample was 57%. Significant correlations were found between childhood sexual abuse and compulsive sexual behaviors, depression, and anxiety. The results of the mediation analyses suggested that depression (B = 0.07, standard error [SE] = 0.03, 95%CI 0.02 to 0.15), but not anxiety (B = 0.02, SE = 0.02, 95%CI-0.2 to 0.07), mediated the link between childhood sexual abuse and compulsive sexual behaviors. The pattern of our results remained the same when controlling for other types of childhood trauma. Conclusions: Depression, not anxiety, appears to mediate the relationship between childhood sexual abuse and compulsive sexual behaviors in men. Future research that tests our mediation analyses using a prospective longitudinal study would be highly informative.
  • article 1 Citação(ões) na Scopus
    Psychometric properties of the Alcohol Use Disorders Identification Test (AUDIT) across cross-cultural subgroups, genders, and sexual orientations: Findings from the International Sex Survey (ISS)
    (2023) HORVATH, Zsolt; NAGY, Lena; KOOS, Monika; KRAUS, Shane W.; DEMETROVICS, Zsolt; POTENZA, Marc N.; BALLESTER-ARNAL, Rafael; BATTHYANY, Dominik; BERGERON, Sophie; BILLIEUX, Joel; BRIKEN, Peer; BURKAUSKAS, Julius; CARDENAS-LOPEZ, Georgina; CARVALHO, Joana; CASTRO-CALVO, Jesus; CHEN, Lijun; CIOCCA, Giacomo; CORAZZA, Ornella; CSAKO, Rita; FERNANDEZ, David P.; FUJIWARA, Hironobu; FERNANDEZ, Elaine F.; FUSS, Johannes; GABRHELIK, Roman; GEWIRTZ-MEYDAN, Ateret; GJONESKA, Biljana; GOLA, Mateusz; GRUBBS, Joshua B.; HASHIM, Hashim T.; ISLAM, Md. Saiful; ISMAIL, Mustafa; JIMENEZ-MARTINEZ, C. Martha; JURIN, Tanja; KALINA, Ondrej; KLEIN, Verena; KOLTO, Andras; LEE, Sang-Kyu; LEWCZUK, Karol; LIN, Chung-Ying; LOCHNER, Christine; LOPEZ-ALVARADO, Silvia; LUKAVSKA, Katerina; MAYTA-TRISTAN, Percy; MILLER, Dan J.; OROSOVA, Olga; OROSZ, Gabor; TEAM, Mami Sungkyunkwan Univ res; PONCE, Fernando P.; QUINTANA, Gonzalo R.; GARZOLA, Gabriel C. Quintero; RAMOS-DIAZ, Jano; RIGAUD, Kevin; ROUSSEAU, Ann; SCANAVINO, Marco De Tubino; SCHULMEYER, Marion K.; SHARAN, Pratap; SHIBATA, Mami; SHOIB, Sheikh; SIGRE-LEIROS, Vera; SNIEWSKI, Luke; SPASOVSKI, Ognen; STEIBLIENE, Vesta; STEIN, Dan J.; STRIZEK, Julian; TSAI, Meng-Che; UNSAL, Berk C.; VAILLANCOURT-MOREL, Marie-Pier; HOUT, Marie Claire Van; BOTHEJ, Beata
    Introduction: Despite being a widely used screening questionnaire, there is no consensus on the most appropriate measurement model for the Alcohol Use Disorders Identification Test (AUDIT). Furthermore, there have been limited studies on its measurement invariance across cross-cultural subgroups, genders, and sexual orientations. Aims: The present study aimed to examine the fit of different measurement models for the AUDIT and its measurement invariance across a wide range of subgroups by country, language, gender, and sexual orientation. Methods: Responses concerning past-year alcohol use from the participants of the cross-sectional International Sex Survey were considered (N = 62,943; Mage: 32.73; SD = 12.59). Confirmatory factor analysis, as well as measurement invariance tests were performed for 21 countries, 14 languages, three genders, and four sexual orientation subgroups that met the minimum sample size requirement for inclusion in these analyses. Results: A two-factor model with factors describing 'alcohol use' (items 1-3) and 'alcohol problems' (items 4-10) showed the best model fit across countries, languages, genders, and sexual orientations. For the former two, scalar and latent mean levels of invariance were reached considering different criteria. For gender and sexual orientation, a latent mean level of invariance was reached. Conclusions: In line with the two-factor model, the calculation of separate alcohol-use and alcohol-problem scores is recommended when using the AUDIT. The high levels of measurement invariance achieved for the AUDIT support its use in cross-cultural research, capable also of meaningful comparisons among genders and sexual orientations.
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  • article 14 Citação(ões) na Scopus
    Compulsive sexual behavior disorder in 42 countries: Insights from the International Sex Survey and introduction of standardized assessment tools
    (2023) BOTHE, Beata; KOOS, Monika; NAGY, Lena; KRAUS, Shane W.; DEMETROVICS, Zsolt; POTENZA, Marc N.; MICHAUD, Aurelie; BALLESTER-ARNAL, Rafael; BATTHYANY, Dominik; BERGERON, Sophie; BILLIEUX, Joel; BRIKEN, Peer; BURKAUSKAS, Julius; CARDENAS-LOPEZ, Georgina; CARVALHO, Joana; CASTRO-CALVO, Jesus; CHEN, Lijun; CIOCCA, Giacomo; CORAZZA, Ornella; CSAKO, Rita; FERNANDEZ, David P.; FERNANDEZ, Elaine F.; FOURNIER, Lois; FUJIWARA, Hironobu; FUSS, Johannes; GABRHELIK, Roman; GEWIRTZ-MEYDAN, Ateret; GJONESKA, Biljana; GOLA, Mateusz; GRUBBS, Joshua B.; HASHIM, T. Hashim; ISLAM, Md. Saiful; ISMAIL, Mustafa; JIMENEZ-MARTINEZ, Martha C.; JURIN, Tanja; KALINA, Ondrej; KLEIN, Verena; KOLTO, Andras; LEE, Chih-Ting; LEE, Sang-Kyu; LEWCZUK, Karol; LIN, Chung-Ying; LOCHNER, Christine; LOPEZ-ALVARADO, Silvia; LUKAVSKA, Katerina; MAYTA-TRISTAN, Percy; MILEA, Ionut; MILLER, Dan J.; OROSOVA, Olga; OROSZ, Gabor; PONCE, Fernando P.; QUINTANA, Gonzalo R.; GARZOLA, Gabriel C. Quintero; RAMOS-DIAZ, Jano; RIGAUD, Kevin; ROUSSEAU, Ann; SCANAVINO, Marco De Tubino; SCHULMEYER, Marion K.; SHARAN, Pratap; SHIBATA, Mami; SHOIB, Sheikh; LEIROS, Vera L. Sigre; SNIEWSKI, Luke; SPASOVSKI, Ognen; STEIBLIENE, Vesta; STEIN, Dan J.; STRIZEK, Julian; STULHOFER, Aleksandar; UNSAL, Berk C.
    Background and aims: Despite its inclusion in the 11th revision of the International Classification of Diseases, there is a virtual paucity of high-quality scientific evidence about compulsive sexual behavior disorder (CSBD), especially in underrepresented and underserved populations. Therefore, we comprehensively examined CSBD across 42 countries, genders, and sexual orientations, and validated the original (CSBD-19) and short (CSBD-7) versions of the Compulsive Sexual Behavior Disorder Scale to provide standardized, state-of-the-art screening tools for research and clinical practice. Method: Using data from the International Sex Survey (N = 82,243; Mage = 32.39 years, SD = 12.52), we evaluated the psychometric properties of the CSBD-19 and CSBD-7 and compared CSBD across 42 countries, three genders, eight sexual orientations, and individuals with low vs. high risk of experiencing CSBD. Results: A total of 4.8% of the participants were at high risk of experiencing CSBD. Country-and gender-based differences were observed, while no sexual-orientation-based differences were present in CSBD levels. Only 14% of individuals with CSBD have ever sought treatment for this disorder, with an additional 33% not having sought treatment because of various reasons. Both versions of the scale demonstrated excellent validity and reliability. Discussion and conclusions: This study contributes to a better understanding of CSBD in underrepresented and underserved populations and facilitates its identification in diverse populations by providing freely accessible ICD-11-based screening tools in 26 languages. The findings may also serve as a crucial building block to stimulate research into evidence-based, culturally sensitive prevention and intervention strategies for CSBD that are currently missing from the literature.