FREDERICO LEON ARRABAL FERNANDES
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
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Agora exibindo 1 - 7 de 7
conferenceObject Non Concordance Between Sputum and Pulmonary Explant Fragments Culture in Patients with Cystic Fibrosis After Lung Transplantation(2018) ATHANAZIO, R. A.; RACHED, S. Z.; STELMACH, R.; CUKIER, A.; CARVALHO-PINTO, R. M.; COSTA, A. N.; FERNANDES, F. L.; SAMANO, M. N.; TEIXEIRA, R. H.; CAMPOS, S. V.- The Role of Exercise in a Weight-Loss Program on Clinical Control in Obese Adults with Asthma A Randomized Controlled Trial(2017) FREITAS, Patricia D.; FERREIRA, Palmira G.; SILVA, Aline G.; STELMACH, Rafael; CARVALHO-PINTO, Regina M.; FERNANDES, Frederico L. A.; MANCINI, Marcia C.; SATO, Maria N.; MARTINS, Milton A.; CARVALHO, Celso R. F.Rationale: Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated. Objectives: To examine the effect of exercise training in a weight loss program on asthma control, quality of life, inflammatory biomarkers, and lung function. Methods: Fifty-five obese patients with asthma were randomly assigned to either a weight-loss program plus exercise (WL + E group, n = 28) or a weight-loss program plus sham (WL + S group, n = 27), where the weight-loss program included nutrition (caloric restriction) and psychological therapies. The WL + E group incorporated aerobic and resistance muscle training, whereas the WL + S group incorporated breathing and stretching exercises. Measurements and Main Results: The primary outcome was clinical improvement in asthma control over 3 months. Secondary outcomes included quality of life, lung function, body composition, aerobic capacity, muscle strength, and inflammatory/antiinflammatory biomarkers. After 3 months, 51 patients were analyzed. Compared with the WL + S group, the WL + E group demonstrated improved clinical control scores (median [25th to 75th percentile],-0.7 [-1.3 to -0.3] vs. -0.3 [-0.9 to 0.4]; P = 0.01) and greater weight loss (mean +/- SD, -6.8% +/- 3.5 vs. -3.1% +/- 2.6; P < 0.001) and aerobic capacity (median [25th to 75th percentile], 3.0 [2.4 to 4.0] vs. 0.9 [-0.3 to 1.3] ml O-2 X kg(-1) X min(-1); P < 0.001). These improvements in the WL + E group were also accompanied by improvements in lung function, antiinflammatory biomarkers, and vitamin D levels, as well as reductions in airway and systemic inflammation. Conclusions: Adding exercise to a short-term weight-loss program should be considered as a useful strategy for achieving clinical control of asthma in obese patients.
conferenceObject Prevalence Of Dinamic Hyperinflation And Aerobic Capacity Assessment In Bronchiectasis Patients(2017) NUCCI, M. N. Maiorano De; FERNANDES, F. L. A.; ATHANAZIO, R. A.; SALGE, J. M.; STELMACH, R.; CUKIER, A.conferenceObject Quantitative Airway Wall Thickness In Severe Asthmatic Patients: An Useful Prognostic Tool But Not Predictor To Therapy(2014) ATHANAZIO, R. A.; CARVALHO-PINTO, R.; JASINOWODOLINSKI, D.; RACHED, S. Z.; MAIORANO, M. C.; FERNANDES, F. L. A.; RABE, K.; CUKIER, A.; STELMACH, R.conferenceObject A Case Of Association Of Pulmonary Actinomycosis And Chronic Cavitary Pulmonary Aspergillosis(2014) RACHED, S. Z.; MAIORANO, M. C. N. T.; ALMEIDA, G. Eler De; ATHANAZIO, R.; CARVALHO-PINTO, R.; FERNANDES, F. Leon Arrabal; STELMACH, R.; CUKIER, A.conferenceObject Mucoid Impaction Can Predict Oral Corticosteroids Response In Severe Asthmatic Patients(2014) ATHANAZIO, R. A.; CARVALHO-PINTO, R.; JASINOWODOLINSKI, D.; FERNANDES, F. L. A.; MAIORANO, M. C.; RACHED, S. Z.; RABE, K. F.; CUKIER, A.; STELMACH, R.conferenceObject Lung Function Impairment And Coronary Calcium Score In Patients Investigating Ischemic Heart Disease(2013) FERNANDES, F. L. A.; PINTO, R. M. D. C.; STELMACH, R.; PESSI, J. D.; SOUZA, E. C. D. S.; CUKIER, A.