FRANCINE MARIA DE ALMEIDA

(Fonte: Lattes)
Índice h a partir de 2011
14
Lattes
ResearcherID
ORCID
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina

Filtros

Limpar filtros

Configurações

search.filters.applied.f.dateIssued: 2023 ×

Resultados de Busca

Agora exibindo 1 - 8 de 8
  • conferenceObject
    Effects of melatonin in an Asthma-COPD overlap model
    (2023) RIBEIRO, Cristiane; SCHEFFER, Vitorio; CAMARGO, Leandro; FUKUZAKI, Silvia; ALMEIDA, Francine; RIGHETTI, Renato; TIBERIO, Iolanda; LEICK, Edna
  • conferenceObject
    Green Areas and PM2,5 exposure could be associated with Asthma and COPD?
    (2023) ALMEIDA, Francine Maria; MOREIRA, Tiana Carla Lopes; OLIVEIRA, Lucas Miranda; RIGHETTI, Renato Fraga; LOPES, Fernanda Degobbi Tenorio Quirino Santos; ALENCAR, Airlane P.; GOUVEIA, Nelson; MAUAD, Thais; LOTUFO, Paulo A.; BENSENOR, Isabela; SANTOS, Itamar Souza; TIBERIO, Iolanda Fatima Lopes Calvo
  • conferenceObject
    Effect of paclitaxel and methotrexate associated with cholesterol-rich nanoemulsions on ischemiareperfusion injury after unilateral lung transplantation in rats
    (2023) BATTOCHIO, Angela; TAVARES, Elaine; CORREIA, Aristides; ALMEIDA, Francine; CARVALHO, Priscila; GUIDO, Maria; PEGO-FERNANDES, Paulo; MARANHAO, Raul; PAZETTI, Rogerio
  • conferenceObject
    Occupational asthma and allergic asthma: differences in the physical activity level, clinical control, and airway inflammation
    (2023) SILVA, Ronaldo Aparecido Da; FREITAS, Lucas Rodrigues Silva; ALMEIDA, Francine Maria De; GALVAO, Clovis Eduardo Santos; NOGUEIRA, Soraia Felix; BEZERRA, Suellen Karoline Moreira; CARVALHO, Celso Ricardo Fernades De; ARAUJO, Kaique Alves De; CRUZ, Fabiola Matos Da; AGONDI, Rosana Camara; MARTINS, Milton Arruda; TIBERIO, Iolanda De Fatima Lopes Calvo; SARAIVA-ROMANHOLO, Beatriz Mangueira
  • conferenceObject
    The imbalance between subpopulations of regulatory T (TREG) Cells at different stages of chronic obstructive pulmonary disease (COPD)
    (2023) ALVES, Luan Henrique Vasconcelos; A, Juliana Tiyaki Ito; OLIVEIRA, Luana Mendonca De; TIBERIO, Iolanda Lopes Calvo; STELMACH, Rafael; SATO, Maria Notomi; ALMEIDA, Francine Maria; LOPES, Fernanda Degobbi Tenorio Quirino dos Santos
  • conferenceObject
    Preventive Effects of Inhibition of Thymic Stromal Lymphopoietin on Bronchial Hyperresponsiveness and Inflammatory Cellular Pattern in an Experimental Model of Chronic Allergic Pulmonary Inflammation Exacerbated by Lipopolysaccharide
    (2023) GRENCHESKI, E. A.; LOPES, B. Q. S.; CRUZ, E. L.; RIGHETTI, R. F.; SANTOS, T. M.; CAMARGO, L. D.; ALMEIDA, F.; SARAIVA-ROMANHOLO, B. M.; PRADO, C. M.; BEZERRA, S. K. M.; PIGATI, P. A.; LOPES, F. D.; LEICK, E. A.; TIBERIO, I. F. L. C.
  • conferenceObject
    Pulmonary function evaluation on Asthma-COPD overlap from ELSA-Brasil cohort study.
    (2023) ALMEIDA, Francine Maria; OLIVEIRA, Roselaine Maria; QUEIROZ, Vitoria Caroline; OLIVO, Clarice Rosa; SARAIVA-ROMANHOLO, Beatriz Mangueira; LOTUFO, Paulo A.; BENSENOR, Isabela; SANTOS, Itamar Souza; TIBERIO, Iolanda Fatima Lopes Calvo
  • article 3 Citação(ões) na Scopus
    Modulating asthma-COPD overlap responses with IL-17 inhibition
    (2023) CAMARGO, Leandro do Nascimento; RIGHETTI, Renato Fraga; ALMEIDA, Francine Maria de; SANTOS, Tabata Maruyama dos; FUKUZAKI, Silvia; MARTINS, Nilo Arthur Bezerra; BARBEIRO, Miguel Cantadori; SARAIVA-ROMANHOLO, Beatriz Mangueira; LOPES, Fernanda Degobbi Tenorio Quirino dos Santos; LEICK, Edna Aparecida; PRADO, Carla Maximo; TIBERIO, Iolanda de Fatima Lopes Calvo
    Background: IL-17 is a modulator of the inflammatory response and is implicated in lung remodeling in both asthma and chronic obstructive pulmonary disease (COPD). Well as and probably in patients with asthma-COPD overlap (ACO).Methods: In this study, we evaluated the response of the airways and alveolar septa to anti-IL-17 treatment in an ACO model. Fifty-six male BALB/c mice were sensitized with ovalbumin (OVA group), received porcine pancreatic elastase (PPE group), or both (ACO group). Mice were then treated with either anti-IL-17 monoclonal antibody or saline. We evaluated hyperresponsiveness, bronchoalveolar lavage fluid (BALF) cell counts, and mean alveolar diameter. We quantified inflammatory, response, extracellular matrix remodeling, oxidative stress markers, and signaling pathway markers.Results: Anti-IL-17 treatment in the ACO anti-IL-17 group reduced the maximum response of respiratory system Rrs, Ers, Raw, Gtis, this when compared to the ACO group (p<0.05). There was a reduction in the total number of inflammatory cells, neutrophils, and macrophages in the BALF in the ACO anti-IL-17 group compared to the ACO group (p<0.05). There was attenuated dendritic cells, CD4+, CD8+, FOXP3, IL-1 beta, IL-2, IL-6, IL-13, IL-17, IL-33 in ACO anti-IL-17 group in airway and alveolar septum compared to the ACO group (p<0.05). We observed a reduction of MMP-9, MMP-12, TIMP-1, TGF-beta, collagen type I in ACO anti-IL-17 group in airway and alveolar septum compared to the ACO group (p < 0.05). We also observed a reduction of iNOS and 8-iso-PGF2 alpha in the airways and in the alveolar septum was reduced in the ACO anti-IL-17group compared to the ACO group (p < 0.05). Regarding the signaling pathways, NF-kB, ROCK-1, and ROCK-2 in the airway and alveolar septum were attenuated in the ACO anti-IL-17 group when compared to the ACO group (p<0.05).Conclusions: Our results suggest that inhibiting IL-17 modulates cell-associated cytokine production in lung tissue, extracellular matrix remodeling, and oxidative stress in ACO through the modulation of NF-kB and FOXP3.