MARTIN ANDRES CORONEL CORDERO

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LIM/35 - Laboratório de Nutrição e Cirurgia Metabólica do Aparelho Digestivo, Hospital das Clínicas, Faculdade de Medicina

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Assunto: Gastroenterology & Hepatology ×

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Agora exibindo 1 - 10 de 23
  • article
    Endoscopic polymer injection and endoluminal plication in treatment of gastroesophageal reflux disease: evaluation of long-term results
    (2018) MOURA, Eduardo Guimaraes Hourneaux De; SAIIUM, Rubens A. A.; NASI, Ary; CORONEL, Martin; MOURA, Diogo Turiani Hourneaux De; MOURA, Eduardo Turiani Hourneaux De; MINATA, Mauricio Kazuyoshi; CURY, Marcelo; FALCAO, Angela; CECCONELLO, Ivan; SAKAI, Paulo
    Background and study aims Us of proton pump inhibitors (PPIs) has made endoscopic treatment of gastroesophageal reflux disease (GERD) more efficient, with reduction in morbidity and complications. However, some patients persist with symptoms despite medical treatment and some are not compliant with it or cannot afford it for financial reasons, and thus they require non-pharmacological therapeutic options such as surgical fundoplication. Surgery may be effective in the short term, but there is related morbidity and concern about its long-term efficacy. The possibility of minimally invasive endoluminal surgeries has resulted in interest in and development of newly endoscopic devices. Good short-term results with surgical fundoplication lack of studies of is with long follow-up justify our interest in this study. The aim of this study was to investigate the efficacy of endoscopic polymer injection and endoluminal full-thickness plication in the long-term control of GERD. Patients and methods Forty-seven patients with GERD who underwent an endoscopic procedure were followed up for 60 months and evaluated for total response (RT), partial response (RP) and no response (SR) to endoscopic treatment with reintroduction of PPIs. Results Twenty-one patients received polymer injection (G0) and 26 endoluminal plication (G1). The number of patients with no response to endoscopic treatment with reintroduction of PPIs increased in time for both techniques (G0 P = 0.006; G1 P < 0.001). There was symptomatic improvement up to 12 months, with progressive loss of this trending up to 60 months in G0 and G1 (P < 0.001). Health-related quality of life score (GERD-HRQL) demonstrated TR in G0 and G1 at 1, 3, 6 and 12 months. The 60-month analysis showed an increased number of patients with SR in both groups. The quality of life assessment (SF-36) showed benefit in G0 up to 3 months. G0 showed a higher rate of complications. There were no deaths. There was healing of esophagitis at 3 months in 45 % of patients in G0 and 40 % in G1. There was no improvement in manometric or pH findings. Conclusion Endoscopic therapies were ineffective in controlling GERD in the long term.
  • article
    Pancreatic Metastasis from Papillary Thyroid Carcinoma: A Case Report
    (2020) MACHADO, Andressa A.; LENZ, Luciano; DOMINGUES, Regina B.; LIMA, Gustavo R. A.; JOSINO, Iatagan R.; CORDERO, Martin A. C.; V, Adriana Safatle-Ribeiro; MARTINS, Bruno C.; PENNACCHI, Caterina M. P. S.; GUSMON, Carla C.; PAULO, Gustavo A.; LIMA, Marcelo S.; BABA, Elisa R.; KAWAGUTI, Fabio S.; UEMURA, Ricardo S.; MALUF-FILHO, Fauze
    Introduction differentiated thyroid carcinoma presents with distant metastasis in 4% of cases, usually occurring in the lungs, bones and thoracic lymph nodes. Pancreatic involvement is extremely rare, with few cases reported in the literature. Case report A 47-years-old female patient presented abdominal pain. She had a history of papillary thyroid carcinoma surgically resected in 2009. After 10 years, computed tomography revealed hepatic lesions suggestive of secondary involvement and a solid mass in the pancreatic head. Endoscopic ultrasound fine-needle aspiration was performed in a heterogeneous hypoechoic mass located at pancreatic head. Cell block with immunohistochemistry was positive for thyroglobulin, suggesting papillary thyroid carcinoma metastasis. The patient still survives at present, treating metastasis with Cabozantinib. Conclusion endoscopic ultrasound fine-needle aspiration is a minimally invasive and accurate method of sampling lesions of the pancreas. In combination with clinical history and immunohistochemistry, can confirm diagnosis and define management.
  • article 0 Citação(ões) na Scopus
    Self-expandable metallic stent-induced esophagorespiratory fistulas in patients with advanced esophageal cancer
    (2023) JOSINO, Iatagan R.; MARTINS, Bruno C.; MACHADO, Andressa A.; LIMA, Gustavo R. de A.; CORDERO, Martin A. C.; POMBO, Amanda A. M.; SALLUM, Rubens A. A.; JR, Ulysses Ribeiro; BARON, Todd H.; MALUF-FILHO, Fauze
    Background/Aims: Self-expandable metallic stents (SEMSs) are widely adopted for the palliation of dysphagia in patients with malignant esophageal strictures. An important adverse event is the development of SEMS-induced esophagorespiratory fistulas (SEMSERFs). This study aimed to assess the risk factors related to the development of SEMS-ERF after SEMS placement in patients with esophageal cancer. Methods: This retrospective study was performed at the Instituto do Cancer do Estado de Sao Paulo. All patients with malignant esophageal strictures who underwent esophageal SEMS placement between 2009 and 2019 were included in the study. Results: Of the 335 patients, 37 (11.0%) developed SEMS-ERF, with a median time of 129 days after SEMS placement. Stent flare of 28 mm (hazard ratio [HR], 2.05; 95% confidence interval [CI], 1.15-5.51; p=0.02) and post-stent chemotherapy (HR, 2.0; 95% CI, 1.01- 4.00; p=0.05) were associated with an increased risk of developing SEMS-ERF, while lower-third tumors were a protective factor (HR, 0.5; 95% CI, 0.26-0.85; p=0.01). No difference was observed in overall survival. Conclusions: The incidence of SEMS-ERFs was 11%, with a median time of 129 days after SEMS placement. Post-stent chemotherapy and a 28 mm stent flare were associated with a higher risk of SEMS-ERF.
  • conferenceObject
    IMPACT OF RADIOTHERAPY (RT) ON ADVERSE EVENTS OF SELF-EXPANDING METALLIC STENTS (SEMS) IN PATIENTS WITH ESOPHAGEAL CANCER
    (2020) MACHADO, Andressa A.; MARTINS, Bruno da Costa; LIMA, Gustavo R.; JOSINO, Iatagan; CORONEL, Martin A.; LIMA, Marcelo S. de; SAFATLE-RIBEIRO, Adriana V.; PENNACCHI, Caterina; GUSMON, Carla C.; BABA, Elisa; KAWAGUTI, Fabio S.; LENZ, Luciano H.; UEMURA, Ricardo S.; PAULO, Gustavo A. de; GEIGER, Sebastian N.; SALLUM, Rubens A.; RIBEIRO, Ulysses; MALUF-FILHO, Fauze
  • article 0 Citação(ões) na Scopus
    Gastrointestinal ischemia: endoscopic findings in the context of vascular insufficiency
    (2019) HOURNEAUX DE MOURA, Diogo Turiani; MADRUGA NETO, Antonio C; BARSOTTI, Gabriel C; CORONEL, Martin; GUEDES, Hugo G; BRUNALDI, Vitor O; ARTIFON, Everson L.A; DE MOURA, Eduardo G.H
    Gastrointestinal ischemia may result from different causes: hemodynamic shock, thromboembolism, endoscopic or surgical complications, among other causes. Its symptoms are pain, vomiting, bleeding and bloating. Endoscopic findings are pale or blackened mucosa, and exudative and confluent ulcerative lesions. This paper aims to report a case of gastroduodenal ischemia associated with hemodynamic shock and disseminated intravascular coagulation (DIC). This is a case of a 56-yearsold male with multiple comorbidities, presenting with refractory septic shock and DIC. He underwent an upper gastrointestinal endoscopy (UGE) for investigation of melena, which revealed an extensive deep and exudative gastric ulcer, associated with edematous purplish duodenal mucosa. Due to the severity of the underlying condition, the patient evolved to death, evidencing septic shock as cause of death. Gastroduodenal ischemia is associated with a poor prognosis, in which early diagnosis by UGE is fundamental to guide potential interventions.
  • conferenceObject
    ESOPHAGORESPIRATORY FISTULAS INDUCED BY SEMS IN THE TREATMENT OF MALIGNANT ESOPHAGEAL STRICTURES
    (2020) JOSINO, Iatagan R.; MACHADO, Andressa A.; LIMA, Gustavo R.; CORONEL, Martin A.; LIMA, Marcelo S. de; KAWAGUTI, Fabio S.; GUSMON, Carla C.; UEMURA, Ricardo S.; PENNACCHI, Caterina; LENZ, Luciano; SAFATLE-RIBEIRO, Adriana V.; BABA, Elisa; GEIGER, Sebastian N.; PAULO, Gustavo A. de; MARTINS, Bruno da Costa; MALUF-FILHO, Fauze
  • conferenceObject
    ENDOSCOPIC FINDINGS IN SEVERE YELLOW FEVER PATIENTS PRESENTING WITH ACUTE UPPER GASTROINTESTINAL BLEEDING: A RETROSPECTIVE CASE SERIES STUDY
    (2019) GALETTI, Facundo; FARIAS, Galileu F.; MARTINS, Rafael K.; CORONEL, Martin A.; REZENDE, Daniel T.; ROCHA, Rodrigo S.; MOURA, Diogo T. de; BRUNALDI, Vitor O.; HO, Yeh-Li; BABA, Elisa; MOURA, Eduardo G. de
  • conferenceObject
    ENDOSCOPIC SLEEVE GASTROPLASTY IN HIV PATIENTS: THE FIRST STUDY EVALUATING EFFECTIVENESS AND SAFETY
    (2019) SOUZA, Thiago F.; MADRUGA NETO, Antonio C.; GRECCO, Eduardo; QUADROS, Luiz G.; CORONEL, Martin A.; NETO, Manoel Galvao
  • conferenceObject
    COMPARISON BETWEEN ENDOSCOPIC SPHINCTEROTOMY VERSUS ENDOSCOPIC SPHINCTEROTOMY ASSOCIATED WITH BALLOON DILATION FOR REMOVAL OF BILE DUCT STONES: A SYSTEMATIC REVIEW AND META-ANALYSIS BASED ON RANDOMIZED CONTROLLED TRIALS.
    (2018) CLEMENTE JUNIOR, Cesar C. de; BERNARDO, Wanderlei M.; FRANZINI, Tomazo; LUZ, Gustavo O.; SANTOS, Marcos E. dos; MARINHO, Fabio R.; CORONEL, Martin A.; SAKAI, Paulo; MOURA, Eduardo G. de
  • article
    Primary adenocarcinoma arising in esophageal colon interposition for corrosive esophageal injury: a case report and review of the literature
    (2018) MOURA, Diogo Turiani Hourneaux De; RIBEIRO, Igor Braga; CORONEL, Martin; MOURA, Eduardo Turiani Hourneaux De; CARVALHO, Joana Rita; BABA, Elisa Ryoka; MOURA, Eduardo Guimaraes Hourneaux De
    Background and study aims Colon interposition for benign strictures is associated with significant perioperative complications that carry high morbidity and mortality. Although rarely reported in the literature, adenocarcinoma can occur as a late complication in an interposed colonic segment. We report a case of a late-stage adenocarcinoma in a colonic interposition performed for benign esophageal stricture.