HAMILTON AUGUSTO ROSCHEL DA SILVA
Projetos de Pesquisa
Unidades Organizacionais
EFE, EEFE - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
12 resultados
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conferenceObject Chronic (24 weeks) Beta-alanine Supplementation Does Not Affect Muscle Taurine Or Blood Clinical Chemistry(2018) SAUNDERS, Bryan; FRANCHI, Mariana; OLIVEIRA, Luana F.; PAINELLI, Vitor S.; SILVA, Vinicius E.; SILVA, Rafael P.; COSTA, Luiz A. R.; SALE, Craig; HARRIS, Roger C.; ROSCHEL, Hamilton; ARTIOLI, Guilherme G.; GUALANO, Bruno- Effects of Creatine Supplementation on Brain Function and Health(2022) FORBES, Scott C.; CORDINGLEY, Dean M.; CORNISH, Stephen M.; GUALANO, Bruno; ROSCHEL, Hamilton; OSTOJIC, Sergej M.; RAWSON, Eric S.; ROY, Brian D.; PROKOPIDIS, Konstantinos; GIANNOS, Panagiotis; CANDOW, Darren G.While the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creatine content in humans. Furthermore, creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain injury and depression but its effect on neurodegenerative diseases appears to be lacking. The purpose of this narrative review is to summarize the current body of research pertaining to creatine supplementation on total creatine and phophorylcreatine (PCr) content, explore GAA as an alternative or adjunct to creatine supplementation on brain creatine uptake, assess the impact of creatine on cognition with a focus on sleep deprivation, discuss the effects of creatine supplementation on a variety of neurological and mental health conditions, and outline recent advances on creatine supplementation as a neuroprotective supplement following traumatic brain injury or concussion.
- 24-Week beta-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males(2020) SAUNDERS, Bryan; FRANCHI, Mariana; OLIVEIRA, Luana Farias de; SILVA, Vinicius da Eira; SILVA, Rafael Pires da; PAINELLI, Vitor de Salles; COSTA, Luiz Augusto Riani; SALE, Craig; HARRIS, Roger Charles; ROSCHEL, Hamilton; ARTIOLI, Guilherme Giannini; GUALANO, BrunoPurpose To investigate the effects of chronic beta-alanine (BA) supplementation on muscle taurine content, blood clinical markers and sensory side-effects. Methods Twenty-five healthy male participants (age 27 +/- 4 years, height 1.75 +/- 0.09 m, body mass 78.9 +/- 11.7 kg) were supplemented with 6.4 g day(-1) of sustained-release BA (N = 16; CarnoSyn (TM), NAI, USA) or placebo (PL; N = 9; maltodextrin) for 24 weeks. Resting muscle biopsies of the m. vastus lateralis were taken at 0, 12 and 24 weeks and analysed for taurine content (BA, N = 12; PL, N = 6) using high-performance liquid chromatography. Resting venous blood samples were taken every 4 weeks and analysed for markers of renal, hepatic and muscle function (BA, N = 15; PL, N = 8; aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase; albumin; globulin; creatinine; estimated glomerular filtration rate and creatine kinase). Results There was a significant main effect of group (p = 0.04) on muscle taurine, with overall lower values in PL, although there was no main effect of time or interaction effect (both p > 0.05) and no differences between specific timepoints (week 0, BA: 33.67 +/- 8.18 mmol kg(-1) dm, PL: 27.75 +/- 4.86 mmol kg(-1) dm; week 12, BA: 35.93 +/- 8.79 mmol kg(-1) dm, PL: 27.67 +/- 4.75 mmol kg(-1) dm; week 24, BA: 35.42 +/- 6.16 mmol kg(-1) dm, PL: 31.99 +/- 5.60 mmol kg(-1) dm). There was no effect of treatment, time or any interaction effects on any blood marker (all p > 0.05) and no self-reported side-effects in these participants throughout the study. Conclusions The current study showed that 24 weeks of BA supplementation at 6.4 g day(-1) did not significantly affect muscle taurine content, clinical markers of renal, hepatic and muscle function, nor did it result in chronic sensory side-effects, in healthy individuals. Since athletes are likely to engage in chronic supplementation, these data provide important evidence to suggest that supplementation with BA at these doses for up to 24 weeks is safe for healthy individuals.
- The Skeletal Muscle Response to Energy Deficiency: A Life History Perspective(2022) OLIVEIRA-JUNIOR, Gersiel; PINTO, Rafaela S.; SHIRLEY, Meghan K.; LONGMAN, Daniel P.; KOEHLER, Karsten; SAUNDERS, Bryan; ROSCHEL, Hamilton; DOLAN, EimearEnergy is a finite resource that is competitively distributed among the body's systems and biological processes. During times of scarcity, energetic ""trade-offs"" may arise if less energy is available than is required to optimally sustain all systems. More immediately essential functions are predicted to be prioritized, even if this necessitates the diversion of energy away from - and potential downregulation of - others. These concepts are encompassed within life history theory, an evolutionary framework with considerable potential to enhance understanding of the evolved biological response to periods of energy deficiency. Skeletal muscle is a particularly interesting tissue to investigate from this perspective, given that it is one of the largest and most energetically costly tissues within the body. It is also highly plastic, responsive to a broad range of stimuli, and contributes to many essential bodily functions, e.g., mechanical, regulatory and storage. These functions may be traded off against each other during periods of energy deficiency, with the nature of the trade-off's dependent on the characteristics of the individual and the circumstances within which the deficit occurs. In this review, we consider the skeletal muscle response to periods of energy deficiency from a life history perspective, along with how this response may be influenced by factors including sex, age, body composition, training and nutritional status.
- A Comparative Study of Hummingbirds and Chickens Provides Mechanistic Insight on the Histidine Containing Dipeptide Role in Skeletal Muscle Metabolism(2018) DOLAN, E.; SAUNDERS, B.; DANTAS, W. S.; MURAI, I. H.; ROSCHEL, H.; ARTIOLI, G. G.; HARRIS, R.; BICUDO, J. E. P. W.; SALE, C.; GUALANO, B.Histidine containing dipeptides (HCDs) have numerous ergogenic and therapeutic properties, but their primary role in skeletal muscle remains unclear. Potential functions include pH regulation, protection against reactive oxygen/nitrogen species, or Ca2+ regulation. In recognition of the challenge of isolating physiological processes in-vivo, we employed a comparative physiology approach to investigate the primary mechanism of HCD action in skeletal muscle. We selected two avian species (i.e., hummingbirds and chickens), who represented the extremes of the physiological processes in which HCDs are likely to function. Our findings indicate that HCDs are non-essential to the development of highly oxidative and contractile muscle, given their very low content in hummingbird skeletal tissue. In contrast, their abundance in the glycolytic chicken muscle, indicate that they are important in anaerobic bioenergetics as pH regulators. This evidence provides new insights on the HCD role in skeletal muscle, which could inform widespread interventions, from health to elite performance.
- Effects of physical activity on vascular function in autoimmune rheumatic diseases: a systematic review and meta-analysis(2021) PECANHA, Tiago; BANNELL, Daniel J.; SIECZKOWSKA, Sofia Mendes; GOODSON, Nicola; ROSCHEL, Hamilton; SPRUNG, Victoria S.; LOW, David A.Objectives. To summarize existing evidence and quantify the effects of physical activity on vascular function and structure in autoimmune rheumatic diseases (ARDs). Methods. Databases were searched (through March 2020) for clinical trials evaluating the effects of physical activity interventions on markers of micro- and macrovascular function and macrovascular structure in ARDs. Studies were combined using random effects meta-analysis, which was conducted using Hedges' g. Meta-analyses were performed on each of the following outcomes: microvascular function [i.e. skin blood flow or vascular conductance responses to acetylcholine (ACh) or sodium nitropusside (SNP) administration]; macrovascular function [i.e. brachial flow-mediated dilation (FMD%) or brachial responses to glyceryl trinitrate (GTN%); and macrovascular structure [i.e. aortic pulse wave velocity (PWV)]. Results. Ten studies (11 trials) with a total of 355 participants were included in this review. Physical activity promoted significant improvements in microvascular [skin blood flow responses to ACh, g=0.92 (95% CI 0.42, 1.42)] and macrovascular function [FMD%, g=0.94 (95% CI 0.56, 1.02); GTN%, g=0.53 (95% CI 0.09, 0.98)]. Conversely, there was no evidence for beneficial effects of physical activity on macrovascular structure [PWV, g=-0.41 (95% CI -1.13, 0.32)]. Conclusions. Overall, the available clinical trials demonstrated a beneficial effect of physical activity on markers of micro- and macrovascular function but not on macrovascular structure in patients with ARDs. The broad beneficial impact of physical activity across the vasculature identified in this review support its role as an effective non-pharmacological management strategy for patients with ARDs.
- A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study(2020) PINTO, Ana Jessica; PECANHA, Tiago; MEIRELES, Kamila; BENATTI, Fabiana Braga; BONFIGLIOLI, Karina; PINTO, Ana Lucia de Sa; LIMA, Fernanda Rodrigues; PEREIRA, Rosa Maria Rodrigues; IRIGOYEN, Maria Claudia Costa; TURNER, James Edward; KIRWAN, John P.; OWEN, Neville; DUNSTAN, David W.; ROSCHEL, Hamilton; GUALANO, BrunoBackground Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to investigate the feasibility and efficacy of a newly developed intervention focused on reducing sedentary time, and potential clinical, physiological, metabolic and molecular effects in rheumatoid arthritis. Methods The Take a STAND for Health study is a 4-month, parallel-group, randomized controlled trial, in which postmenopausal patients with rheumatoid arthritis will set individually tailored, progressive goals to replace their sedentary time with standing and light-intensity activities. Patients will be recruited from the Clinical Hospital (School of Medicine, University of Sao Paulo) and will be assessed at baseline and after a 4-month follow up. Outcomes will include objectively measured sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition; aerobic fitness, muscle function, blood pressure, cardiovascular autonomic function, vascular function and structure, health-related quality of life, and food intake. Blood and muscle samples will be collected for assessing potential mechanisms, through targeted and non-targeted approaches. Discussion Findings will be of scientific and clinical relevance with the potential to inform new prescriptions focused on reducing sedentary behavior, a modifiable risk factor that thus far has been overlooked in patients with rheumatoid arthritis.
- Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation(2017) GONCALVES, Livia de Souza; PAINELLI, Vitor de Salles; YAMAGUCHI, Guilherme; OLIVEIRA, Luana Farias de; SAUNDERS, Bryan; SILVA, Rafael Pires da; MACIEL, Erika; ARTIOLI, Guilherme Giannini; ROSCHEL, Hamilton; GUALANO, BrunoThis study investigates the influence of habitual caffeine intake on aerobic exercise-performance responses to acute caffeine supplementation. A double-blind, crossover, counterbalanced study was performed. Forty male endurancetrained cyclists were allocated into tertiles, according to their daily caffeine intake: low (58 +/- 29 mg/d), moderate (143 +/- 25 mg/d), and high (351 +/- 139 mg/d) consumers. Participants completed three trials in which they performed simulated cycling time trials (TTs) in the fastest time possible following ingestion of the following: caffeine (CAF: 6 mg/kg body mass), placebo (PLA), and no supplement (CON). A mixed-model analysis revealed that TT performance was significantly improved in CAF compared with PLA and CON (29.92 +/- 2.18 vs. 30.81 +/- 2.67 and 31.14 +/- 2.71 min, respectively; P = 0.0002). Analysis of covariance revealed no influence of habitual caffeine intake as a covariate on exercise performance (P = 0.47). TT performance was not significantly different among tertiles (P = 0.75). No correlation was observed between habitual caffeine intake and absolute changes (CAF = CON) in TT performance with caffeine (P = 0.524). Individual analysis showed that eight, seven, and five individuals improved above the variation of the test in CAF in the low, moderate, and high tertiles, respectively. A Fisher's exact test did not show any significant differences in the number of individuals who improved in CAF among the tertiles (P > 0.05). Blood lactate and ratings of perceived exertion were not different between trials and tertiles (P > 0.05). Performance effects of acute caffeine supplementation during an similar to 30-min cycling TT performance were not influenced by the level of habitual caffeine consumption.
- Infographic. A systematic review and meta-analysis of the effect of beta-alanine supplementation on exercise capacity and performance(2020) SAUNDERS, Bryan; VIRGILE, Adam; ELLIOTT-SALE, Kirsty Jayne; ARTIOLI, Guilherme Giannini; SWINTON, Paul A.; DOLAN, Eimear; ROSCHEL, Hamilton; SALE, Craig; GUALANO, Bruno
conferenceObject Individual Data Meta-analysis Provides No Evidence Of Individual Response Variation For Individuals Supplementing With Beta-alanine(2021) ESTEVES, Gabriel Perri; SWINTON, Paul; SALE, Craig; JAMES, Ruth; ARTIOLI, Guilherme Giannini; ROSCHEL, Hamilton; GUALANO, Bruno; SAUNDERS, Bryan; DOLAN, Eimear