REGINA MARIA DE CARVALHO PINTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
bookPart Asma(2017) MAIORANO, Maria Cecília Nieves Teixeira; PINTO, Regina Maria Carvalho- The Role of Exercise in a Weight-Loss Program on Clinical Control in Obese Adults with Asthma A Randomized Controlled Trial(2017) FREITAS, Patricia D.; FERREIRA, Palmira G.; SILVA, Aline G.; STELMACH, Rafael; CARVALHO-PINTO, Regina M.; FERNANDES, Frederico L. A.; MANCINI, Marcia C.; SATO, Maria N.; MARTINS, Milton A.; CARVALHO, Celso R. F.Rationale: Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated. Objectives: To examine the effect of exercise training in a weight loss program on asthma control, quality of life, inflammatory biomarkers, and lung function. Methods: Fifty-five obese patients with asthma were randomly assigned to either a weight-loss program plus exercise (WL + E group, n = 28) or a weight-loss program plus sham (WL + S group, n = 27), where the weight-loss program included nutrition (caloric restriction) and psychological therapies. The WL + E group incorporated aerobic and resistance muscle training, whereas the WL + S group incorporated breathing and stretching exercises. Measurements and Main Results: The primary outcome was clinical improvement in asthma control over 3 months. Secondary outcomes included quality of life, lung function, body composition, aerobic capacity, muscle strength, and inflammatory/antiinflammatory biomarkers. After 3 months, 51 patients were analyzed. Compared with the WL + S group, the WL + E group demonstrated improved clinical control scores (median [25th to 75th percentile],-0.7 [-1.3 to -0.3] vs. -0.3 [-0.9 to 0.4]; P = 0.01) and greater weight loss (mean +/- SD, -6.8% +/- 3.5 vs. -3.1% +/- 2.6; P < 0.001) and aerobic capacity (median [25th to 75th percentile], 3.0 [2.4 to 4.0] vs. 0.9 [-0.3 to 1.3] ml O-2 X kg(-1) X min(-1); P < 0.001). These improvements in the WL + E group were also accompanied by improvements in lung function, antiinflammatory biomarkers, and vitamin D levels, as well as reductions in airway and systemic inflammation. Conclusions: Adding exercise to a short-term weight-loss program should be considered as a useful strategy for achieving clinical control of asthma in obese patients.
- Compare the safety of constant-load or intensity interval training for clinically stables patients with moderate and severe asthma(2017) SILVA, Ronaldo Aparecido Da; ROCCO, Patricia Goncalves Leite; MAZZUCATTO, Flavio; QUEIROS, Douglas Silva; STELMACH, Rafael; CARVALHO-PINTO, Regina Maria de; MARTINS, Milton Arruda; CARVALHO, Celso Ricardo Fernandes
- Factors associated with balance impairment in COPD patients(2017) XAVIER, Rafaella; PEREIRA, Ana Carolina; LOPES, Aline; SILVA, Cibele Marques da; CUKIER, Alberto; PINTO, Regina Carvalho; CARVALHO, Celso
- Mast cell subtypes in adults and children with severe asthma(2017) ARAUJO-PAULINO, Bianca Bergamo de; ELLER, Miriam Cardoso Neves; VERGANI, Karina Pierantozzi; CARVALHO-PINTO, Regina Maria; STELMACH, Rafael; YOSHIZAKI, Kelly; GROTH, Espen Elias; RODRIGUES, Joaquim; DOLHNIKOFF, Marisa; MAUAD, Thais
- Omalizumab in patients with severe uncontrolled asthma: well-defined eligibility criteria to promote asthma control(2017) CARVALHO-PINTO, Regina Maria de; AGONDI, Rosana Camara; GIAVINA-BIANCHI, Pedro; CUKIER, Alberto; STELMACH, Rafael
- High intensity interval training increases aerobic fitness, health related quality of life and clinical control in patients from moderate to severe asthma(2017) SILVA, Ronaldo Aparecido Da; ROCCO, Patricia Goncalves Leite; MAZZUCATO, Flavio; FERNANDES, Thiago; CUKIER, Alberto; STELMACH, Rafael; CARVALHO-PINTO, Regina Maria de; MARTINS, Milton Arruda; CARVALHO, Celso Ricardo Fernandes
- Identification of phenotypes in COPD patients: influence of physical activity in daily life, body composition and skeletal muscle strength(2017) XAVIER, Rafaella; LOPES, Aline; PEREIRA, Ana Carolina; PINTO, Regina Maria Carvalho; CUKIER, Alberto; STELMACH, Rafael; RAMOS, Ercy Mara; CARVALHO, Celso
- Effects of aerobic and breathing exercises on clinical control and airway inflammation in persistent asthma(2017) EVARISTO, Karen Brandao; SACCOMANI, Milene Granja; CUKIER, Alberto; STELMACH, Rafael; CARVALHO-PINTO, Regina; SANTAELLA, Danilo F.; ROJO, Marcos; SARAIVA-ROMANHOLO, Beatriz M.; MARTINS, Milton Arruda; CARVALHO, Celso R. F.
- Asthmatics are physically active, but have low level of clinical control, aerobic fitness, and psychosocial morbidity(2017) SILVA, Ronaldo Aparecido Da; ROCCO, Patricia Goncalves Leite; MAZZUCATO, Flavio; QUEIROZ, Doulgas Silva; STELMACH, Rafael; CARVALHO-PINTO, Regina Maria de; CUKIER, Alberto; MARTINS, Milton Arruda; CARVALHO, Celso Ricardo Fernandes