MARA SANDRA HOSHIDA
Projetos de Pesquisa
Unidades Organizacionais
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
conferenceObject Longitudinal serum levels of Placental Growth Factor and sFlt-1 throughout gestation in normotensive pregnancies and those complicated by hypertensive disorders(2013) COSTA, R. A.; HOSHIDA, M. S.; ALVES, E. A.; V, R. P. Francisco; ZUGAIB, M.Background: Preeclampsia (PE) prevalence is higher in women with chronic hypertension (CH). Predictive markers for PE in this group could be particularly important. We aimed to evaluate serum levels of PlGF and sFlt-1 throughout pregnancies complicated by isolated PE, CH and PE superimposed on CH (PE+CH) compared to normotensive (NT) pregnancies. Methods: Peripheral blood samples have been collected from NT and CH pregnancies at gestational ages of 20, 26, 32 and 36 weeks and stored to be assayed by ELISA. This study was approved by local Ethics Committee. To date, samples have been partially assayed. Results: Levels of sFlt-1 increased throughout pregnancy in all groups. Levels of PlGF increased until 32 weeks in pregnancies not complicated by PE (NT and CH) and until 26 weeks in those complicated by PE (PE and PE+HC), thereafter PlGF levels decreased in all groups. Conclusions: preliminary data, still too short for statistical testing.- EFFECT OF THE MICROENVIRONMENT ON THE PLACENTAL BEHAVIOUR: RESPONSE OF THE CHORIONIC VILLI TO NORMAL AND PREECLAMPTIC PREGNANT SERUM(2017) PRADO, Karen; CASTRO, Karla; LORENZON-OJEA, Aline; CARDOSO, Elaine; HOSHIDA, Mara; ALVES, Eliane; FRANCISCO, Rossana P. Vieira; ZUGAIB, Marcelo; BEVILACQUAL, Estela
conferenceObject IFN CHANGES PHAGOSOMAL MARKERS IN TROPHOBLAST CELLS(2014) HOSHIDA, Mara; AMARANTE-PAFFARO, Andrea; BEVILACQUA, Estela- EXPRESSION OF HLA-G, HLA-E AND HLA-F IN THE CHORIODECIDUAL INTERFACE OF COMPLETE HYDATIDIFORM MOLES(2019) LIN, Lawrence; TOSCANO, Marcello; HOSHIDA, Mara; SCHULTZ, Regina; FUSHIDA, Koji; FRANCISCO, Rossana
conferenceObject Cross-talk between trophoblastic cells and maternal immune cells coordinated by Ccl25 Ccr9 during mouse embryo implantation(2013) WEINGRILL, R. B.; HOSHIDA, M. S.; MARTINHAGO, C. D.; BEVILACQUA, E.Background: CC’ and CXC’terminal chemokines are known to be involved with the polarity of blastocyst and uterus, leukocyte recruitment and capture/coordination of leukocyte migration. Particularly the chemokine CCL25 is expressed by the mouse trophoblast cells during implantation phase. Objectives: The aim of this study is to investigate the expression and localization of Ccl25 and its receptor Ccr9 during the mouse embryo implantation period. Methodology: Ccl25 and Ccr9 transcript abundance was measured by qPCR on fl ushed blastocyst from gestation days (gd) 3.5, 4.5, 5.5 and 7.5 and protein by immunofluorescence on frozen sections of implantation sites and on fl ushed blastocyst from gd4.5, 5.5 and 7.5. Results: Blastocyst expression of Ccl25/Ccr9 mRNA increased on gd4.5 and 5.5 and 7.5. Ccl25 was immunolocalized at trophoblast cells surrounding the blastocyst and glandular and uterine luminal epithelial cells, while Ccr9 was expressed at leukocytes inside maternal vessels surrounding the implanting embryo. Conclusion: Expression of chemokine /receptor during blastocyst implantation suggests a role and likely a cross-talk between trophoblast cells and the maternal immune cells and adds new elements to the understanding of trophoblast interactions during embryo implantation.- THE IMMUNOSUPPRESSANT DRUG AZATHIOPRINE INDUCES EXPRESSION OF IL-18 IN PLACENTAL CELLS(2019) ARAUJO, Franciele; OLIVEIRA, Leandro; HOSHIDA, Mara; FRANCISCO, Rossana P. V.; MARINHO, Claudio; BEVILACQUA, Estela
conferenceObject CRIPTO1/3 MODULATES INVASION OF TROPHOBLAST HTR8/SV-NEO CELL LINEAGE(2015) BANDEIRA, Carla L.; HOSHIDA, Mara S.; KNOFLER, Martin; PANZETTA-DUTARI, Graciela M.; GENTI-RAIMONDI, Suasana; RIDANO, Magali E.; FRANCISCO, Rossana P. V.; BEVILACQUA, Estela- DECIDUAL IMMUNE CELL INFILTRATION AND PROGRESSION TO POST-MOLAR TROPHOBLASTIC NEOPLASIA(2019) LIN, Lawrence; TOSCANO, Marcello; HOSHIDA, Mara; SCHULTZ, Regina; FUSHIDA, Koji; FRANCISCO, Rossana
- SERUM OF PATIENTS WITH PREECLAMPSIA ACTIVATES UPR-PERK PATHWAY IN HUMAN TROPHOBLAST CELL LINE HTR8/SVNEO(2019) CASTRO, Karla; PRADO, Karen; LORENZON-OJEA, Aline; FRANCISCO, Rossana; ZUGAIB, Marcelo; HOSHIDA, Mara; ALVES, Eliane; VERAS, Mariana; BEVILACQUA, Estela
conferenceObject EXTRAVILLOUS CYTOTROPHOBLAST EXPRESSION OF CRIPTO ISOFORMS(2015) BANDEIRA, C. L.; HOSHIDA, M. S.; FRANCISCO, R. P. V.; KNOEFLER, M.; BEVILACQUA, E.