MARIA ANGELICA PERES
Projetos de Pesquisa
Unidades Organizacionais
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
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conferenceObject Chronicle air pollution exposition and semen quality in hypercolesterolemic mice(2013) PERES, M. A.; CASTRO, K.; RIBEIRO-JUNIOR, G.; MENDES, C.; LOSANO, J.; VERAS, M.; SALDIVA, P.Air pollution (AP) is associated to lose of semen quality. It is also known that some population groups are more susceptible to atmospheric pollution effects due to a pre-existing health condition. This work detailed the effects AP in semen quality of mice knockout for low density lipoprotein receptor that represents an important risk group of human population. Animals were exposed to AP during pre and/or post natal period until adult life, with or without hypercholesterolemic diet. Semen analysis comprised sperm number and morphology, membrane, acrosome and DNA integrity, mitochondrial activity, oxidative stress and cytokines expression of seminal vesicle. The combination of the three factors (AP pre/post natal exposure and hypercholesterolemia) negatively impacted DNA fragmentation, mitochondrial activity, membrane integrity and oxidative stress. Other parameters did not show significant differences. Air pollution combined with hypercholesterolemia condition potentiated the negative effects on important parameters of semen leading male mice to present low fertility/infertility.conferenceObject Murine uterine receptivity markers are affected by particulate air pollution in a dose response manner(2013) CASTRO, K. R.; RIBEIRO-JUNIOR, R.; PERES, M.; SALDIVA, P.; MATSUDA, M.; VERAS, M.Air pollution (AP) is associated with increased rates of implantation failures in mice. The uterus requires a variety of factors to become receptive: cytokines (LIF), anti-adhesion (MUC-1) molecules and hormonal induced morphological changes. This study investigated the effects of chronic exposure to AP on uterine receptivity. Female mice were exposed to either filtered air or 2 different daily doses of AP. Estrous cycle, ovarian and uterine weight, number of corpora lutea (CL), uterine histopathology, LIF and MUC-1 expression were evaluated. Effects were dose dependent. Estrous cycle showed shorter duration with extended diestrus. Ovarian weights were increased without change in CL number. Histopathology indicated a decrease in volume and thickness of endometrium and increased diameter and thickness of glandular and luminal epithelium. MUC-1 expression was not altered but LIF was decreased during the implantation window. This suggests that AP exposure negatively affects endometrial receptivity altering the fine regulation of decidualization mediated by LIF expression.