HELIO ELKIS
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Psiquiatria, Faculdade de Medicina - Docente
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- RANDOMIZED AND CONTROLLED TRIAL TO EVALUATE THE EFFICACY OF OCCUPATIONAL THERAPY IN THE REHABILITATION OF EXECUTIVE FUNCTIONS IN PATIENTS WITH TREATMENT-RESISTANT SCHIZOPHRENIA(2019) VIZZOTTO, Adriana; CELESTINO, Diego; BUCHAIN, Patricia; OLIVEIRA, Alexandra; OLIVEIRA, Graca; SARNO, Elaine Di; NAPOLITANO, Isabel; ELKIS, Helio
- ANDES NETWORK - STUDYING EARLY PSYCHOSIS IN LATIN AMERICA(2019) CROSSLEY, Nicolas; GUINJOAN, Salvador; RIVERA, Guillermo; JACKOWSKI, Andrea; GADELHA, Ary; ELKIS, Helio; LOUZA, Mario; GAMA, Clarissa; EVANS-LACKO, Sara; CASTANEDA, Carmen Paz; UNDURRAGA, Eduardo; CORDOBA, Rodrigo; LOPEZ-JARAMILLO, Carlos; FUENTE-SANDOVAL, Camilo de la; BRESSAN, Rodrigo
- Schizophrenia TreAtment with electRic Transcranial Stimulation (STARTS): design, rationale and objectives of a randomized, double-blinded, sham-controlled trial(2019) VALIENGO, Leandro; GORDON, Pedro Caldana; DE CARVALHO, Juliana Barbosa; RIOS, Rosa Maria; KOEBE, Stephanie; SERPA, Mauricio Henrique; VAN DE BILT, Martinus; LACERDA, Acioly; ELKIS, Helio; GATTAZ, Wagner Farid; BRUNONI, André RussowskyAbstract Introduction Schizophrenia is a severe mental disorder. While some antipsychotic medications have demonstrated efficacy in treating positive symptoms, there is no widely recognized treatment for negative symptoms, which can cause significant distress and impairment for patients with schizophrenia. Here we describe the rationale and design of the STARTS study (Schizophrenia TreAtment with electRic Transcranial Stimulation), a clinical trial aimed to test the efficacy of a non-pharmacological treatment known as transcranial direct current stimulation (tDCS) for treating the negative symptoms of schizophrenia Methods The STARTS study is designed as a randomized, sham-controlled, double-blinded trial evaluating tDCS for the treatment of the negative symptoms of schizophrenia. One-hundred patients will be enrolled and submitted to 10 tDCS sessions over the left dorsolateral prefrontal cortex (anodal stimulation) and left temporoparietal junction (cathodal stimulation) over 5 consecutive days. Participants will be assessed using clinical and neuropsychological tests before and after the intervention. The primary outcome is change in the Positive and Negative Syndrome Scale (PANSS) negative subscale score over time and across groups. Biological markers, including blood neurotrophins and interleukins, genetic polymorphisms, and motor cortical excitability, will also be assessed. Results The clinical results will provide insights about tDCS as a treatment for the negative symptoms of schizophrenia, and the biomarker investigation will contribute towards an improved understanding of the tDCS mechanisms of action. Conclusion Our results could introduce a novel therapeutic technique for the negative symptoms of schizophrenia. Clinical trial registration: ClinicalTrials.gov, NCT02535676 .
- Can the Positive and Negative Syndrome scale (PANSS) differentiate treatment-resistant from non-treatment-resistant schizophrenia? A factor analytic investigation based on data from the Pattern cohort study(2019) FREITAS, Rosana; SANTOS, Bernardo dos; ALTAMURA, Carlo; BERNASCONI, Corrado; CORRAL, Ricardo; EVANS, Jonathan; MALLA, Ashok; KREBS, Marie-Odile; NORDSTROEM, Anna-Lena; ZINK, Mathias; HARO, Josep Maria; ELKIS, HelioTreatment-Resistant Schizophrenia (TRS) and Non-Treatment-Resistant Schizophrenia (NTRS) may represent different subtypes of schizophrenia. However, few studies have investigated their PANSS symptom dimensions by Exploratory (EFA) or Confirmatory (CFA). Data from the present study are derived from 1429 patients of the Pattern study. TRS was defined by the use of clozapine in the previous year whereas NTRS by the use of non-clozapine antipsychotics (""by proxy""). Factors were chosen based on the Kaiser criterion and considered valid when loadings were greater than or equal to 0.5. The fit to the data was evaluated by CFA in comparison with well-established PANSS models, using fit indexes. The EFA yielded similar five-factor model in both groups: Negative, Positive, Anxiety/Depression, Cognitive and Excited. CFA showed a satisfactory, but not perfect, fit to the data, as compared with the previous PANSS factor analytic models. Despite the limitations regarding the 'by proxy' definition of TRS, the results of the present study show that there are no differences in the factorial structure of PANSS in patients with TRS and NTRS.