WALTER YUKIHIKO TAKAHASHI
Projetos de Pesquisa
Unidades Organizacionais
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
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- Natural history of diabetic macular edema and factors predicting outcomes in sham-treated patients (MEAD study)(2019) YOON, Young Hee; BOYER, David S.; MATURI, Raj K.; BANDELLO, Francesco; BELFORT, Rubens; AUGUSTIN, Albert J.; LI, Xiao-Yan; BAI, Zhanying; HASHAD, Yehia; ABUJAMRA, Suel; ACTON, James; ALI, Fareed; ANTOSZYK, Andrew; AUGUSTIN, Albert J.; AWH, Carl C.; BARAK, Adiel; BARTZ-SCHMIDT, Karl Ulrich; BAUMAL, Caroline R.; BELFORT JR., Rubens; BHENDE, Muna; BOYER, David S.; BRIDGES JR., William Z.; BROWN, David M.; CARMICHAEL, Trevor; CARNEVALE, Ken; CASELLA, Antonio M.; CHANG, Tom; CHECHIK, Daniel; CHEN, San-Ni; CHONG, Lawrence P.; CHONG, Victor; CORWIN, Joel; CREUZOT-GARCHER, Catherine; CRUESS, Alan; DANIELL, Mark; AVILA, Marcos P. de; MORAES JR., Haroldo Vieira de; DEVENYI, Robert G.; DOFT, Bernard H.; DONALDSON, Mark; DREYER, Richard; ELIOTT, Dean; ENGEL, Harry M.; ERNEST, Jan; ESSMAN, Thomas F.; FALCONE, Philip M.; FEKRAT, Sharon; FERENCZ, Joseph R.; FERREIRA, Joao L.; FIGUEIRA, Joao; FISER, Ivan; FOSTER, Bradley; FOX, Gregory M.; FREEMAN, William R.; GARG, S. P.; GILLIES, Mark; GLASER, David; GOLDSTEIN, Burton G.; GOMES, Andre M. V.; GONDER, John R.; GOPAL, Lingam; GOUS, Petrus; GUPTA, Amod; GUPTA, Anurag; HALPERIN, Lawrence; HAN, Dennis; HARIPRASAD, Seenu M.; HOLZ, Frank G.; KAISER, Peter; KALVODOVA, Bohdana; KATZ, Barrett; KATZ, Randy S.; KECIK, Dariusz; KELLAWAY, Judianne; KLEMPERER, Itamar; KUPPERMANN, Baruch; LANZETTA, Paolo; LATTANZIO, Rosangela; LEE, Won-Ki; LEHR, John; LEYS, Monique; LOOSE, Isaac; LOTERY, Andrew; LU, Da-Wen; MCCARTNEY, Paul; MAJJI, Ajit B.; MARTINEZ, Jose A.; MASSIN, Pascale; MATURI, Raj K.; MENCHINI, Ugo; MENON, Geeta; MICHELS, Mark; MIDENA, Edoardo; MILLER JR., James; MITCHELL, Paul; MOISSEIEV, Joseph; MORSE, Lawrence; NAVARRO, Rafael; NEMETH, Janos; NEWLAND, Henry; NEWSOM, Richard; NICHOLS, John; ORELLANA, Juan; ORZALESI, Nicola; PARANHOS JR., Augusto; PARK, Robert; PARK, Susanna; PARODI, Maurizio Battaglia; PAVAN, Peter R.; PEACE, James; PEREZ-ORTIZ, Don J.; POLLACK, Ayala; RAMASWAMY, Kim; RATNAKARAM, Ramakrishna; RAVALICO, Giuseppe; REHAK, Jiri; REZAEI, Kourous; RIZZO, Stanislao; RODRIGUEZ-ALVIRA, Francisco J.; ROMANET, Jean-Paul; ROSE, Steven; ROSEN, Richard B.; ROSSETTI, Luca; RUIZ-MORENO, Jose Maria; SADDA, SriniVas; SALL, Kenneth; SANDNER, Dirk; SANZ, Alvaro Fernandez-Vega; SARTANI, Gil; SCHMICKLER, Stefanie; SCHWARTZ, Steven D.; SHARMA, Y. R.; SHEU, Shwu-Jiuan; SINGER, Michael; SIVAPRASAD, Sobha; SOUBRANE, Gisele; SOUCEK, Petr; SOUIED, Eric H.; STAURENGHI, Giovanni; STUDNICKA, Jan; SUAREZ-FIGUEROA, Marta; TAKAHASHI, Walter Y.; TOGNETTO, Daniele; TSAI, Patrick L.; II, Lawrence J. Ulanski; UY, Harvey S.; VARANO, Monica; VEITH, Miroslav; VICHA, Igor; VIOLA, Francesco; VISSER, Linda; WEINBERGER, Dov; WING, Glenn L.; WONG, Edmund; WONG, Tien Y.; WYLEGALA, Edward; YAN, Jiong; YOON, Young Hee; YOUNG, Lucy H.; YU, Hyeong G.; ZIMMER-GALLER, Ingrid E.Purpose To describe the natural history of diabetic macular edema (DME) with respect to best-corrected visual acuity (BCVA) and central retinal thickness (CRT) outcomes and to identify baseline patient characteristics and systemic factors associated with improvement or worsening of outcomes in sham-treated patients. Methods The study population was sham-treated patients (n = 350) in the 3-year MEAD registration study of dexamethasone intravitreal implant for treatment of DME. Patients had center-involved DME and received sham intravitreal injections in the study eye at >= 6-month intervals. Potential prognostic factors for outcomes were evaluated using multiple linear regression analysis. Results Visual and anatomic outcomes were poorer in patients who left the study early (n = 198) than in study completers (n = 152). Mean change in BCVA from baseline at the last visit with available data was + 0.9 letters; 37.5% of patients had no change in BCVA, 23.2% had gained > 10 letters, and 16.0% had lost > 10 letters. Older age and baseline diabetic retinopathy score > 6 were associated with worse BCVA outcomes; thicker baseline CRT and larger number of hypertension medications used were associated with larger reductions in CRT during the study. Conclusions BCVA and CRT outcomes were variable in this population of DME patients with generally good glycemic control. In DME patients without active treatment, older age and baseline diabetic retinopathy score > 6 were associated with less improvement in BCVA; thicker baseline CRT and a larger number of antihypertensive medications used predicted better improvement in CRT.
- Confluent Endpoint Subthreshold Argon Laser for Serous Macular Detachment in Tilted Disc Syndrome Refractory to Anti-VEGF(2017) ABALEM, Maria Fernanda; CARRICONDO, Pedro Carlos; SANTOS, Helen Nazareth Veloso dos; GARCIA, Rafael; QIAN, Cynthia X.; HELAL JR., John; SOUZA, Eduardo Cunha de; TAKAHASHI, Walter YukihikoA 70-year-old woman presented with 20/200 visual acuity in the right eye. Multimodal imaging revealed tilted disc syndrome (TDS) with macular serous detachment (MSD) and pigmentary changes at the temporal margin of the optic disc. Subretinal fluid persisted after three monthly intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA) injections and threshold focal laser photocoagulation. Subsequently, confluent subthreshold argon laser was applied over the entire area of retinal pigment epithelium (RPE) abnormalities, resulting in the resolution of subretinal fluid without recurrence through 3 years of followup. Subthreshold argon laser treatment may serve as a therapeutic option for MSD in TDS. Targeting leakage sites and stimulating RPE cells might help absorb subretinal fluid.
- Intraoperative Infusion-related Jet Stream Enlargement of Macular Hole(2016) ZACHARIAS, Leandro C.; REZENDE, Flavio A.; SUZUKI, Ana Claudia F.; TANAKA, Tatiana; AZEVEDO, Breno Marques Da Silva; TAKAHASHI, Walter Y.