PAULO ROSSI MENEZES

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Departamento de Medicina Preventiva, Faculdade de Medicina - Docente
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder

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  • article 0 Citação(ões) na Scopus
    Social and clinical features associated with duration of untreated psychosis in the Brazilian STREAM study
    (2021) SHUHAMA, Rosana; ROCHA, Victoria Helena Stelzer; LOUREIRO, Camila Marcelino; CORSI-ZUELLI, Fabiana; SANTOS, Jair Licio Ferreira; MENEZES, Paulo Rossi; DEL-BEN, Cristina Marta
  • article 4 Citação(ões) na Scopus
    Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study
    (2021) AJNAKINA, Olesya; RODRIGUEZ, Victoria; QUATTRONE, Diego; FORTI, Marta di; VASSOS, Evangelos; ARANGO, Celso; BERARDI, Domenico; BERNARDO, Miguel; BOBES, Julio; HAAN, Lieuwe de; DEL-BEN, Cristina Marta; GAYER-ANDERSON, Charlotte; JONGSMA, Hannah E.; LASALVIA, Antonio; TOSATO, Sarah; LLORCA, Pierre-Michel; MENEZES, Paulo Rossi; RUTTEN, Bart P.; SANTOS, Jose Luis; SANJUAN, Julio; SELTEN, Jean-Paul; SZOKE, Andrei; TARRICONE, Ilaria; D'ANDREA, Giuseppe; RICHARDS, Alexander; TORTELLI, Andrea; VELTHORST, Eva; JONES, Peter B.; ROMERO, Manuel Arrojo; CASCIA, Caterina La; KIRKBRIDE, James B.; OS, Jim van; O'DONOVAN, Mick; MURRAY, Robin M.
    Duration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain insights into the possible biological impact on DUP, we report genetic analyses of a large multi-center phenotypically well-defined sample encompassing individuals with a diagnosis of FEP recruited from 6 countries spanning 17 research sites, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. Genetic propensity was measured using polygenic scores for schizophrenia (SZ-PGS), bipolar disorder (BD-PGS), major depressive disorder (MDD-PGS), and intelligence (IQ-PGS), which were calculated based on the results from the most recent genome-wide association meta-analyses. Following imputation for missing data and log transformation of DUP to handle skewedness, the association between DUP and polygenic scores (PGS), adjusting for important confounders, was investigated with multivariable linear regression models. The sample comprised 619 individuals with a diagnosis of FEP disorders with a median age at first contact of 29.0 years (interquartile range [IQR] = 22.0-38.0). The median length of DUP in the sample was 10.1 weeks (IQR = 3.8-30.8). One SD increases in SZ-PGS, BD-PGS, MDD-PGS or IQ-PGS were not significantly associated with the length of DUP. Our results suggest that genetic variation does not contribute to the DUP in patients with a diagnosis of FEP disorders.
  • article 6 Citação(ões) na Scopus
    Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
    (2021) BERENDSEN, Steven; KAPITEIN, Pim; SCHIRMBECK, Frederike; TRICHT, Mirjam J. van; MCGUIRE, Philip; MORGAN, Craig; GAYER-ANDERSON, Charlotte; KEMPTON, Matthew J.; VALMAGGIA, Lucia; QUATTRONE, Diego; FORTI, Marta di; GAAG, Mark van der; KIRKBRIDE, James B.; JONGSMA, Hannah E.; JONES, Peter B.; PARELLADA, Maria; ARANGO, Celso; ARROJO, Manuel; BERNARDO, Miguel; SANJUAN, Julio; SANTOS, Jose Luis; SZOKE, Andrei; TORTELLI, Andrea; LLORCA, Pierre-Michel; TARRICONE, Ilaria; TRIPOLI, Giada; FERRARO, Laura; CASCIA, Caterina La; LASALVIA, Antonio; TOSATO, Sarah; MENEZES, Paulo Rossi; DEL-BEN, Cristina Marta; NELSON, Barnaby; RIECHER-ROSSLER, Anita; BRESSAN, Rodrigo; BARRANTES-VIDAL, Neus; KREBS, Marie-Odile; NORDENTOFT, Merete; RUHRMANN, Stephan; SACHS, Gabriele; RUTTEN, Bart P. F.; OS, Jim van; VELTHORST, Eva; HAAN, Lieuwe de
  • article 1 Citação(ões) na Scopus
    Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis
    (2021) LOUREIRO, Camila Marcelino; CORSI-ZUELLI, Fabiana; FACHIM, Helene Aparecida; SHUHAMA, Rosana; CHAGAS, Natalia Mota de Souza; MENEZES, Paulo Rossi; DEL-BEN, Cristina Marta; LOUZADA-JUNIOR, Paulo
    We investigated the feasibility of including plasma anti-NMDAR antibody screening in the assessment of first-episode psychosis patients in an early intervention programme in the Southern hemisphere. Anti-NMDAR IgG antibodies were assessed by ELISA in 166 patients (64.0% men), 166 matched population-based controls and 76 patients' siblings (30.3% men). Fisher's exact test and ANOVA were performed. Positive anti-NMDAR antibody patients were more often observed in bipolar disorder (10.0%) than schizophrenia (2.4%) or psychotic depression (3.1%), although no significant differences were observed. Our results are not conclusive regarding the inclusion of plasma anti-NMDAR IgG antibodies in differential diagnostic protocols for psychosis.
  • bookPart
    Epidemiologia
    (2021) CARVALHO, Heráclito Barbosa de; LUNA, Expedito José de Albuquerque; GOUVEIA, Nelson da Cruz; ROSSI, Paulo; MATIJASEVICH, Alicia; PERES, Maria Fernanda Tourinho
  • bookPart
    A estrutura de acesso à saúde mental no Sistema Único de Saúde do estado de São Paulo
    (2021) MENEZES, Paulo; ELIAS, Rosangela; CAYRES, Alina Zoqui de Freitas
  • article 7 Citação(ões) na Scopus
    Burnout among primary health care workers in Brazil: results of a multilevel analysis
    (2021) SILVA, Andrea Tenorio Correia da; LOPES, Claudia de Souza; SUSSER, Ezra; COUTINHO, Leticia Maria Silva; GERMANI, Ana Claudia Camargo Goncalves; MENEZES, Paulo Rossi
    Purpose Burnout among health care workers may hamper the quality of care and effectiveness of health systems. Hence, we examined the prevalence of burnout in primary care teams, including community health workers; and investigated associations between individuals' characteristics, team and primary care center factors, and burnout. Methods We carried out a cross-sectional study among primary care teams in the city of Sao Paulo, Brazil (n = 2940). We randomly selected 66 primary care centers. The Maslach burnout inventory was used to investigate burnout. We used multilevel modelling to examine the associations between individuals' characteristics, team and primary care center variables with burnout. Results We addressed 351 primary care teams, with 11.4% of participants presenting severe burnout. The variance in burnout among primary care workers was partially explained by individuals' characteristics, and by team and primary care center factors. Severe burnout was associated with the following: (1) individuals' characteristics: being black, being younger, a higher length of employment in primary care, and presenting a lack of feedback from supervisors; (2) team factors: working in deprived areas and not receiving the support of a multidisciplinary team; and (3) primary care center factors: inadequate infrastructure (less than one office available per team), and having a bad/very bad relationship with the community council. Conclusions To reduce burnout among primary care teams, stakeholders should: (1) train managers/supervisors on leadership styles that prioritize performance feedback, support, and communication skills; (2) allocate catchment areas to teams according to each community's vulnerability; (3) provide a multidisciplinary team to support primary care workers; and (4) offer suitable facilities and infra-structure.
  • article 49 Citação(ões) na Scopus
    Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis: results from the EU-GEI case-control study
    (2021) JONGSMA, Hannah E.; GAYER-ANDERSON, Charlotte; TARRICONE, Ilaria; VELTHORST, Eva; VEN, Els van der; QUATTRONE, Diego; FORTI, Marta di; MENEZES, Paulo Rossi; DEL-BEN, Christina Marta; ARANGO, Celso; LASALVIA, Antonio; BERARDI, Domenico; CASCIA, Caterina La; BOBES, Julio; BERNARDO, Miguel; SANJUAN, Julio; SANTOS, Jose Luis; ARROJO, Manuel; HAAN, Lieuwe de; TORTELLI, Andrea; SZOKE, Andrei; MURRAY, Robin M.; RUTTEN, Bart P.; OS, Jim van; MORGAN, Craig; JONES, Peter B.; KIRKBRIDE, James B.
    Background. Ethnic minority groups in Western countries face an increased risk of psychotic disorders. Causes of this long-standing public health inequality remain poorly understood. We investigated whether social disadvantage, linguistic distance and discrimination contributed to these patterns. Methods. We used case-control data from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study, carried out in 16 centres in six countries. We recruited 1130 cases and 1497 population-based controls. Our main outcome measure was first-episode ICD-10 psychotic disorder (F20-F33), and exposures were ethnicity (white majority, black, mixed, Asian, North-African, white minority and other), generational status, social disadvantage, linguistic distance and discrimination. Age, sex, paternal age, cannabis use, childhood trauma and parental history of psychosis were included as a priori confounders. Exposures and confounders were added sequentially to multivariable logistic models, following multiple imputation for missing data. Results. Participants from any ethnic minority background had crude excess odds of psychosis [odds ratio (OR) 2.03, 95% confidence interval (CI) 1.69-2.43], which remained after adjustment for confounders (OR 1.61, 95% CI 1.31-1.98). This was progressively attenuated following further adjustment for social disadvantage (OR 1.52, 95% CI 1.22-1.89) and linguistic distance (OR 1.22, 95% CI 0.95-1.57), a pattern mirrored in several specific ethnic groups. Linguistic distance and social disadvantage had stronger effects for first- and later-generation groups, respectively. Conclusion. Social disadvantage and linguistic distance, two potential markers of sociocultural exclusion, were associated with increased odds of psychotic disorder, and adjusting for these led to equivocal risk between several ethnic minority groups and the white majority.
  • article 37 Citação(ões) na Scopus
    Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients: the EU-GEI case-control study
    (2021) QUATTRONE, Diego; FERRARO, Laura; TRIPOLI, Giada; CASCIA, Caterina La; QUIGLEY, Harriet; QUATTRONE, Andrea; JONGSMA, Hannah E.; PESCHIO, Simona Del; GATTO, Giusy; GAYER-ANDERSON, Charlotte; JONES, Peter B.; KIRKBRIDE, James B.; BARBERA, Daniele La; TARRICONE, Ilaria; BERARDI, Domenico; TOSATO, Sarah; LASALVIA, Antonio; SZOKE, Andrei; ARANGO, Celso; BERNARDO, Miquel; BOBES, Julio; BEN, Cristina Marta Del; MENEZES, Paulo Rossi; LLORCA, Pierre-Michel; SANTOS, Jose Luis; SANJUAN, Julio; TORTELLI, Andrea; VELTHORST, Eva; HAAN, Lieuwe de; RUTTEN, Bart P. F.; LYNSKEY, Michael T.; FREEMAN, Tom P.; SHAM, Pak C.; CARDNO, Alastair G.; VASSOS, Evangelos; OS, Jim van; MORGAN, Craig; REININGHAUS, Ulrich; LEWIS, Cathryn M.; MURRAY, Robin M.; FORTI, Marta Di
    Background Daily use of high-potency cannabis has been reported to carry a high risk for developing a psychotic disorder. However, the evidence is mixed on whether any pattern of cannabis use is associated with a particular symptomatology in first-episode psychosis (FEP) patients. Method We analysed data from 901 FEP patients and 1235 controls recruited across six countries, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. We used item response modelling to estimate two bifactor models, which included general and specific dimensions of psychotic symptoms in patients and psychotic experiences in controls. The associations between these dimensions and cannabis use were evaluated using linear mixed-effects models analyses. Results In patients, there was a linear relationship between the positive symptom dimension and the extent of lifetime exposure to cannabis, with daily users of high-potency cannabis having the highest score (B = 0.35; 95% CI 0.14-0.56). Moreover, negative symptoms were more common among patients who never used cannabis compared with those with any pattern of use (B = -0.22; 95% CI -0.37 to -0.07). In controls, psychotic experiences were associated with current use of cannabis but not with the extent of lifetime use. Neither patients nor controls presented differences in depressive dimension related to cannabis use. Conclusions Our findings provide the first large-scale evidence that FEP patients with a history of daily use of high-potency cannabis present with more positive and less negative symptoms, compared with those who never used cannabis or used low-potency types.
  • article 5 Citação(ões) na Scopus
    Recruitment, training and supervision of nurses and nurse assistants for a task-shifting depression intervention in two RCTs in Brazil and Peru
    (2021) ROCHA, Thais Izabel Ugeda; ASCHAR, Suzana Crismanis de Almeida Lopes; HIDALGO-PADILLA, Liliana; DALEY, Kate; CLARO, Heloisa Garcia; CASTRO, Hellen Carolina Martins; SANTOS, Daniela Vera Cruz dos; MIRANDA, J. Jaime; ARAYA, Ricardo; MENEZES, Paulo Rossi
    Background Task-shifting and technology in psychological interventions are two solutions to increasing access to mental health intervention and overcoming the treatment gap in low and middle-income countries. The CONEMO intervention combines a smartphone app with support from non-specialized professionals, aiming to treat depression in patients with diabetes and/or hypertension. The aim of this paper is to describe the process of recruitment, training and supervision of the non-specialized professionals who participated in the CONEMO task-shifting intervention in Brazil and Peru. Methods We described and analyzed data related to the recruitment, training and supervision of 62 nurse assistants from the health system in Sao Paulo, Brazil, and three hired nurses in Lima, Peru. The data were collected from information provided by nurses and nurse assistants, supervisor records from supervision meetings and the CONEMO platform database. Results We found that task-shifting was feasible using existing resources in Sao Paulo and additional human resources in Lima. Training and supervision were found to be crucial and well received by the staff; however, time was a limitation when using existing human resources. Ensuring technological competence prior to the start of the intervention was essential. Group supervision meetings allowed non-specialized professionals to learn from each other's experiences. Conclusion Carefully considering recruitment, training and supervision of non-specialized professionals is important for effective task-shifting when delivering an mHealth intervention for depression. Opportunities and challenges of working in different health systems are described, which should be considered in future implementation, either for research or real settings. Trial registration NCT028406662 (Sao Paulo), NCT03026426 (Peru).