EDUARDO HIROSHI AKAISHI
Projetos de Pesquisa
Unidades Organizacionais
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
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- Current practice of Latin American centers in the treatment of peritoneal diseases with cytoreductive surgery with HIPEC(2018) QUADROS, C. A.; LAPORTE, G. A.; HUGUENIN, J. F. L.; BARRETO, E. J. S. S.; V, A. Barros; OLIVEIRA, A. F.; CARVALHO, A. L. L.; PETRUZZIELLO, A.; PAULA, A. C.; URBANO-RUIZ, A.; SANTOS, C. C.; GALHARDO, C. A. V. G.; JOHNSON, L. F. P.; VENDRAME, C. D.; SANTANA, D. P.; AKAISHI, E.; FERREIRA, F. O.; QUEIROZ, F. L.; MIRANDA, F. A. C. L.; LISSA, F. C. T.; SARMENTO, B. J. Q.; NASCIMENTO, G. J. S.; NOVASKI, G. L.; MEINHARDT, J. G. J.; MALI-JUNIOR, J.; V, J. Barreto-Junior; SALOMAO-JUNIOR, L. R.; V, C. Pinto; CAVALLA, C.; SANCHEZ-LORIA, F. A.; COELHO-JUNIOR, M. J. P.; PERROTTA, F. M.; FLORES-AYALA, E. G.; MARTINEZ-SAID, H.; DE-LA-FUENTE, H.; LOPEZ-BASAVE, H. N.; SANDOVAL-JAUREGUI, J.; BUTTE, J. M.; FLOREZ, J. P.; RUSO, M. L.; BELOTTO, M.; MATUS, R. R. G.; SOUZA-FILHO, O.; CAMARA, P. C.; SEITENFUS, R.; ANSELMI-JUNIOR, R. A.; CUTAIT, R.; V, R. M. L. Leal; BOFF, M. F.; SABBAG, R.; SILVA, R. G.; MORAN, A. R.; SALCEDO-HERNANDEZ, R. A.; AGUIAR-JUNIOR, S.; RAMIREZ, S. R.; REIS, T. J. C. C.; BATISTA, T. P.; FRANCISCHETTO, T.; GAVA, V. G.; ARIAS, F.; CASTRO, J. M. M.; PACHECO, M.; GARCIA, M. M.; VENANCIO, C.; LEONARDI, P. C.; ZANATTO, R. M.; WAINSTEIN, A. J. A.; CORDEIRO, E. Z.; PERINA, A. L. F.; FIGUEIREDO, P. H. M.; PEREIRA, L. F.; MOLINA, M. E.; VAZQUEZ, V. L.; TEIXEIRA-JUNIOR, F. J. R.Introduction: A combination therapy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been proposed as a treatment option in patients with peritoneal metastasis of colorectal, ovarian, gastric cancers and sarcomas and as a current standard treatment for pseudomyxoma peritonei and peritoneal mesothelioma. There is a need to standardize its indication, drugs selection along with their concentrations and ways to deliver peritoneal chemotherapy solutions for best outcomes. Aim of the study: To investigate the current practice of Latin American (LA) Centers in which peritoneal diseases (PD) are treated. Patient and Methods: All centers from Latin American Registry of Peritoneal Diseases (LARPD) were invited to participate in a two rounds online survey, to describe their current practice in all indications of CRS with HIPEC for PD. Results: 76 out of 84 LARPD's centers answered the survey, with a response rate of 90,5%. The results represent the current practice of 248 surgeons that are members of LARPD's centers, in 8 LA countries, that at the time of the study had treated 2682 patients with CRS with HIPEC. All current practice aspects including indications, contra-indications, patient selection, methods of peritoneal chemotherapy delivery and treatment protocols are described in this manuscript. Conclusions: This survey is the first LA effort to publish current practice indications and treatment protocols of PD. Achieving consensus of best therapeutic options is essential to provide the best possible outcomes for patients with PD who could benefit from CRS with HIPEC therefore aiming at standardization of the procedure.
- Effect of cytoreductive surgery and HIPEC on survival in comparison to palliative chemotherapy for biliary carcinoma with peritoneal metastasis: A multi-institutional cohort from PSOGI and BIG RENAPE groups.(2018) MERCIER, Frederic; AMBLARD, Iris; BARTLETT, David L.; LEVINE, Edward Allen; BARATTI, Dario; PISO, Pompiliu; MORRIS, David L.; RAU, Beate; TENTES, Antonios Apostolos K.; TUECH, Jean-Jacques; QUENET, Francois; AKAISHI, Eduardo Hiroshi; POCARD, Marc; YONEMURA, Yutaka; LORIMIER, Gerard; DELROEUX, Delphine; VILLENEUVE, Laurent; GLEHEN, Olivier; PASSOT, Guillaume
- Sporadic Abdominal Wall Desmoid type Fibromatosis: treatment paradigm after thirty two years(2018) COUTO NETTO, S. D.; TEIXEIRA, F.; MENEGOZZO, C. A. M.; LEAO-FILHO, H. M.; ALBERTINI, A.; FERREIRA, F. O.; AKAISHI, E. H.; UTIYAMA, E. M.Background: Desmoid-type fibromatosis is a benign mesenchymal neoplastic process. It exhibits an uncertain growth pattern and high recurrence rate. Previously radical surgical resection was the mainstay of treatment but recently more surgeons are opting for conservative management with observation (""wait and see"" policy). The authors intend to evaluate different therapeutic modalities and ontological outcomes for abdominal wall desmoid tumors. Methods: We performed a retrospective study of patients who underwent surgical, hormonal or chemotherapy treatment for abdominal wall desmoid tumors between 1982 to 2014 at two institutions affiliated with the University of Sao Paulo, Brazil. Results: In the study period, 32 patients were included. Twenty-seven patients had surgery upfront. Of those, 89% were women with a median age of 33 years. Mean tumor size was 10 cm. Pathology confirmed free margins in 92% of resections. Tumor recurrence rate was 11%, with median relapse-free survival being 24 months. Multivariate analysis showed that positive final margins (p < 0.001) and positive frozen section (p = 0.001) were independent predictors of recurrence. For the 5 patients who underwent pharmacological therapy, median age was 33 years and median tumor diameter before treatment was 13 cm. Four patients exhibited partial response by Response Evaluation Criteria in Solid Tumors (RECIST). The single patient who did not respond to RECIST underwent radiotherapy. Conclusion: Desmoid tumor treatment has been evolving over the past decade towards a more conservative approach. Pharmacological treatment may result in tumor size regression. When surgical excision is indicated, positive margins represent an important prognostic factor for local tumor recurrence.