ANA CRISTINA BREITHAUPT FALOPPA
Projetos de Pesquisa
Unidades Organizacionais
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
26 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 26
conferenceObject FEMALE RATS PRESENT HIGHER LUNG INFLAMMATION AFTER BRAIN DEATH FOLLOWED BY EX VIVO PERFUSION(2021) RICARDO-DA-SILVA, Fernanda Yamamoto; ARMSTRONG- JR., Roberto; OTTENS, Petra; ZANDEN, Judith van; VIDAL-DOS-SANTOS, Marina; MOREIRA, Luiz Felipe Pinho; ERASMUS, Michiel; LEUVENINK, Henri; BREITHAUPT-FALOPPA, Ana Cristina- Equity, Diversity and Inclusion (EDI) in Organ Transplantation: An ESOT Survey About EDI Within ESOT as an Organization and its Educational Activities, and Transplantation Research and Science(2023) PENGEL, L. H. M.; KAISAR, M.; BENJAMENS, S.; IBRAHIM, M.; RICCI, V.; BELLINI, M. I.; BREITHAUPT-FALOPPA, A. C.; FALK, C.; MAPLE, H.; MARSON, L.; ORTIZ, F.; PAPALOIS, V.; PAREDES, D.; FORSBERG, A.The European Society of Organ Transplantation (ESOT) strives to promote equity, diversity, and inclusion (EDI) across all its activities. We surveyed the transplant community's experiences and perspectives regarding EDI within ESOT as an organization and its educational activities, and research in general. A total of 299 respondents completed the questionnaire. About half agreed that ESOT's Executive Committee, Council, and Sections/Committees are diverse and inclusive (51%) and that ESOT promotes EDI in its live and digital educational activities (54%). Forty percent of respondents agreed that scientific and clinical trials in the field of transplantation are diverse and inclusive. Despite the wide distribution of the survey, most of the respondents self-identified as White and were either physician or surgeon. However, the results contribute a unique insight into the experiences and perspectives of the transplantation community regarding EDI. Whilst ESOT is committed to the principles of EDI, perceptions and the high number of proposals show the apparent need to prioritize efforts to embed EDI across ESOT and transplantation science. These data should constitute a starting point for change and provide guidance for future efforts to promote EDI within the transplantation community.
conferenceObject SEX-DIFFERENCES ON PLATELET AGGREGATION AND MICROVASCULAR PERFUSION AFTER BRAIN DEATH IN RATS(2019) CORREIA, Cristiano de Jesus; BREITHAUPT-FALOPPA, Ana Cristina; SILVA, Raphael dos Santos Coutinho e; SANTOS, Marina Vidal dos; ANUNCIACAO, Lucas Ferreira da; LEUVENINK, Hendrik Gerrit Derk; MOREIRA, Luiz Felipe PinhoconferenceObject SEX DIMORPHISM IN INTESTINAL FUNCTION AFTER INTESTINAL ISCHEMIA/REPERFUSION INJURY(2015) FANTOZZI, Evelyn Thais; RICARDO-DA-SILVA, Fernanda Yamamoto; SANTIAGO-ROCHA, Barbara Lais; RODRIGUES-GARBIN, Sara; OLIVEIRA-FILHO, Ricardo Martins; BREITHAUPT-FALOPPA, Ana Cristina; TAVARES-DE-LIMA, Wothan- Sexual Dimorphism in Lung Inflammatory Process After Brain Death Induction in Rats(2014) MOREIRA, L. P.; FERREIRA, S. G.; KUDO, G. K.; CORREIRA, C. J.; TAVARES-DE-LIMA, W.; BREITHAUPT-FALOPPA, A. C.; SANNOMIYA, P.
conferenceObject ESTRADIOL TREATMENT MODULATES ESTRADIOL RECEPTORS EXPRESSION AND REDUCES RENAL INJURY AFTER BRAIN DEATH IN FEMALE RATS(2021) CORREIA, Cristiano; ARMSTRONG- JR., Roberto; RICARDO-DA-SILVA, Fernanda Yamamoto; VIDAL-DOS-SANTOS, Marina; ANUNCIACAO, Lucas Ferreira Da; MOREIRA, Luiz Felipe Pinho; LEUVENINK, Henri; BREITHAUPT-FALOPPA, Ana CristinaconferenceObject SEX DIFFERENCES ON DONOR LEUKOCYTE MOBILIZATION AND ORGAN INFLAMMATION AFTER BRAIN DEATH(2015) BREITHAUPT-FALOPPA, Ana Cristina; GOMES, Ferreira Sueli; KONISHI, Kudo Guilherme; RESTIVO, Simao Raif; ARMSTRONG JR., Roberto; SANNOMIYA, Paulina; MOREIRA, Luiz FelipeconferenceObject EFFECTS OF 17BETA-ESTRADIOL ON A SUDDEN ONSET BRAIN DEATH MODEL IN MALE RATS(2017) VIEIRA, Roberta Figueiredo; BREITHAUPT-FALOPPA, Ana Cristina; MATSUBARA, Bruno Carvalho; RODRIGUES, Geovana; SANCHES, Marcelo Petrof; FERREIRA, Sueli Gomes; CORREIA, Cristiano De Jesus; MOREIRA, Luiz Felipe; SANNOMIYA, Paulina- The influence of female sex hormones on lung inflammation after brain death - an experimental study(2020) ABIB, Ana Luisa de Oliveira Bonnano; CORREIA, Cristiano de Jesus; ARMSTRONG- JR., Roberto; RICARDO-DA-SILVA, Fernanda Yamamoto; FERREIRA, Sueli Gomes; VIDAL-DOS-SANTOS, Marina; MOREIRA, Luiz Felipe Pinho; RIFFO-VASQUEZ, Yanira; BREITHAUPT-FALOPPA, Ana CristinaOrgan donor's age negatively influences graft survival of organs, increasing risk of complications. Aging occurs in both men and women; however, the menopause marks a decrease in sex hormones and a sudden increase in the process of vascular aging. We investigated sex hormones' influence on the lung inflammatory process induced by BD in female rats. Wistar rats were grouped as: female rats from high estradiol to heat period (non-OVx) and ovariectomized (OVx) female rats. Ovariectomy was carried out 10 days before BD. BD was induced using intracranial balloon rapid inflation. Serum hormones and inflammatory mediators were quantified, leukocytes and platelets counted and lung samples were collected for RT-PCR, immunohistochemical, and histological analysis. Female sex hormones and corticosterone were reduced 6 h after BD in non-OVx group. The infiltration of leukocytes in female non-OVx lungs was higher compared to OVx. G-CSF, VEGF, and CINC-1 were found increased in non-OVx group serum in comparison to OVx. Lung mediators were increased in non-OVx rats compared to controls. The acute reduction of sex hormones induced by BD appears to have a worse effect on lung inflammation than a reduction that has happened over a prolonged period of time, allowing a physiological adaptation prior to BD.
- Cardiac MicroRNA Expression Profile After Experimental Brain Death Is Associated With Myocardial Dysfunction and Can Be Modulated by Hypertonic Saline(2022) FERREIRA, Ludmila Rodrigues Pinto; CORREIA, Cristiano Jesus; ZANONI, Fernando Luiz; CARVALHO-SILVA, Ana Carolina; ZANIRATTO, Ricardo; CANDIDO, Darlan da Silva; ALMEIDA, Rafael Ribeiro; BREITHAUPT-FALOPPA, Ana Cristina; CUNHA-NETO, Edecio; MOREIRA, Luiz Felipe P.Background. Brain death (BD) is associated with systemic inflammatory compromise, which might affect the quality of the transplanted organs. This study investigated the expression profile of cardiac microRNAs (miRNAs) after BD, and their relationship with the observed decline in myocardial function and with the changes induced by hypertonic saline solution (HSS) treatment. Methods. Wistar rats were assigned to sham-operation (SHAM) or submitted to BD with and without the administration of HSS. Cardiac function was assessed for 6 h with left ventricular (LV) pressure-volume analysis. We screened 641 rodent miRNAs to identify differentially expressed miRNAs in the heart, and computational and functional analyses were performed to compare the differentially expressed miRNAs and find their putative targets and their related enriched canonical pathways. Results. An enhanced expression in canonical pathways related to inflammation and myocardial apoptosis was observed in BD induced group, with 2 miRNAs, miR-30a-3p, and miR-467f, correlating with the level of LV dysfunction observed after BD. Conversely, HSS treated after BD and SHAM groups showed similar enriched pathways related to the maintenance of heart homeostasis regulation, in agreement with the observation that both groups did not have significant changes in LV function. Conclusions. These findings highlight the potential of miRNAs as biomarkers for assessing damage in BD donor hearts and to monitor the changes induced by therapeutic measures like HSS, opening a perspective to improve graft quality and to better understand the pathophysiology of BD. The possible relation of BD-induced miRNA's on early and late cardiac allograft function must be investigated.
- «
- 1 (current)
- 2
- 3
- »