IVAN BENADUCE CASELLA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
8 resultados
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- Impact of the period of the day on all-cause mortality and major cardiovascular complications after arterial vascular surgeries(2023) ARTIOLI, Thiago; GUALANDRO, Danielle Menosi; CARDOZO, Francisco Akira Malta; ROJAS, Maria Carmen Escalante; CALDERARO, Daniela; YU, Pai Ching; CASELLA, Ivan Benaduce; LUCCIA, Nelson de; CARAMELLI, BrunoBackgroundConflicting results are reported about daytime variation on mortality and cardiac outcomes after non-cardiac surgeries. In this cohort study, we evaluate whether the period of the day in which surgeries are performed may influence all-cause mortality and cardiovascular outcomes in patients undergoing non-cardiac arterial vascular procedures. Methods1,267 patients who underwent non-cardiac arterial vascular surgeries between 2012 and 2018 were prospectively included in our cohort and categorized into two groups: morning (7 a.m. to 12 a.m., 79%) and afternoon/night (12:01 p.m. to 6:59 a.m. in the next day, 21%) surgeries. Primary endpoint was all-cause mortality within 30 days and one year. Secondary endpoints were the incidence of perioperative myocardial injury/infarction (PMI), and the incidence of major adverse cardiac events (MACE, including acute myocardial infarction, acute heart failure, arrhythmias, cardiovascular death) at hospital discharge. ResultsAfter adjusting for confounders in the multivariable Cox proportional regression, all-cause mortality rates at 30 days and one year were higher among those who underwent surgery in the afternoon/night (aHR 1.6 [95%CI 1.1-2.3], P = 0.015 and aHR 1.7 [95%CI 1.3-2.2], P < 0.001, respectively). Afternoon/night patients had higher incidence of PMI (aHR 1.4 [95%CI 1.1-1.7], P < 0.001). There was no significant difference in the incidence of MACE (aHR 1.3 [95%CI 0.9-1.7], P = 0.074). ConclusionsIn patients undergoing arterial vascular surgery, being operated in the afternoon/night was independently associated with increased all-cause mortality rates and incidence of perioperative myocardial injury/infarction.
- Carotid stenosis management: a review for the internist(2014) CARMO, Gabriel Assis Lopes; CALDERARO, Daniela; GUALANDRO, Danielle Menosi; CASELLA, Ivan Benaduce; YU, Pai Ching; MARQUES, Andre Coelho; CARAMELLI, BrunoStroke is one of the most important causes of mortality and morbidity worldwide and, for a long time, was the leading cause of death in developed countries. Atherothrombotic carotid stenosis is one of the most important etiologies behind this event. If properly recognized and treated, lives can be saved, as well as long-term disabilities prevented. With population aging and improvements in surgical and clinical care, patients with several comorbidities will be referred for revascularization procedures more frequently, posing a challenge for physicians. The purpose of this review is to provide internists and clinicians with information based on several studies so they can offer to their patients, the best evidence-based care, indicating appropriate medical therapy, as well as referral to a vascular surgeon, or what contraindicates endarterectomy or angioplasty, depending on individual characteristics.
conferenceObject Impact of the period of the day on mortality and major cardiovascular complications after vascular surgeries(2020) CARDOZO, F. A. M.; ARTIOLI, T.; CARAMELLI, B.; CALDERARO, D.; YU, P. C.; ROJAS, M. C. E.; CASELLA, I. B.; LUCCIA, N. De; GUALANDRO, D. M.conferenceObject Predictors of acute heart failure after vascular surgery(2015) GUALANDRO, D. M.; MARCONDES-BRAGA, F. G.; YU, P. C.; CARDOZO, F. A. M.; LLOBET, G. B.; CALDERARO, D.; MELO, E. S.; CASELLA, I. B.; LUCCIA, N.; CARAMELLI, B.- Atualização e enfoque em operações vasculares arteriais da II diretriz de avaliação perioperatória da Sociedade Brasileira de Cardiologia(2013) MARQUES, Andre Coelho; BELLEN, Bonno Van; CARAMELLI, Bruno; PRESTI, Calogero; PINHO, Claudio; CALDERARO, Daniela; GUALANDRO, Danielle Menosi; CARVALHO, Francine Correa de; CARMO, Gabriel Assis Lopes do; CASELLA, Ivan Benaduce; FORNARI, Luciana S.; VACANTI, Luciano Janussi; VIEIRA, Marcelo Luiz Campos; MONACHINI, Maristela C.; LUCCIA, Nelson de; YU, Pai Ching; FARSKY, Pedro Silvio; HEINISCH, Roberto Henrique; GUALANDRO, Sandra F. Menosi; MATHIAS JR., Wilson
- Sinus Bradycardia Persisting for 9 Days after Carotid Angioplasty and Stenting(2012) KRUTMAN, Mariana; CALDERARO, Daniela; CASELLA, Ivan Benaduce; CARAMELLI, Bruno; WOLOSKER, Nelson; PUECH-LEAO, Pedro
- Prediction of major cardiac events after vascular surgery(2017) GUALANDRO, Danielle M.; PUELACHER, Christian; LURATIBUSE, Giovanna; LLOBET, Gisela B.; YU, Pai C.; CARDOZO, Francisco A.; GLARNER, Noemi; ZIMMERLI, Andres; ESPINOLA, Jaqueline; CORBIERE, Sydney; CALDERARO, Daniela; MARQUES, Andre C.; CASELLA, Ivan B.; LUCCIA, Nelson de; OLIVEIRA, Mucio T.; LAMPART, Andreas; BOLLIGER, Daniel; STEINER, Luzius; SEEBERGER, Manfred; KINDLER, Christoph; OSSWALD, Stefan; GURKE, Lorenz; CARAMELLI, Bruno; MUELLER, ChristianObjective: Predicting cardiac events is essential to provide patients with the best medical care and to assess the riskbenefit ratio of surgical procedures. The aim of our study was to evaluate the performance of the Revised Cardiac Risk Index (Lee) and the Vascular Study Group of New England Cardiac Risk Index (VSG) scores for the prediction of major cardiac events in unselected patients undergoing arterial surgery and to determine whether the inclusion of additional risk factors improved their accuracy. Methods: The study prospectively enrolled 954 consecutive patients undergoing arterial vascular surgery, and the Lee and VSG scores were calculated. Receiver operating characteristic curves for each cardiac risk score were constructed and the areas under the curve (AUCs) compared. Two logistic regression models were done to determine new variables related to the occurrence of major cardiac events (myocardial infarction, heart failure, arrhythmias, and cardiac arrest). Results: Cardiac events occurred in 120 (12.6%) patients. Both scores underestimated the rate of cardiac events across all risk strata. The VSG score had AUC of 0.63 (95% confidence interval [CI], 0.58-0.68), which was higher than the AUC of the Lee score (0.58; 95% CI, 0.52-0.63; P =.03). Addition of preoperative anemia significantly improved the accuracy of the Lee score to an AUC of 0.61 (95% CI, 0.58-0.67; P =.002) but not that of the VSG score. Conclusions: The Lee and VSG scores have low accuracy and underestimate the risk of major perioperative cardiac events in unselected patients undergoing vascular surgery. The Lee score's accuracy can be increased by adding preoperative anemia. Underestimation of major cardiac complications may lead to incorrect risk-benefit assessments regarding the planned operation.
conferenceObject Coronary Artery Disease, Epicardial Adipose Tissue and Perioperative Risk in Patients Undergoing Abdominal Aortic Aneurysm Repair Surgery(2019) RODRIGUES, Caio Vinicius F.; TELES, Gustavo; WANDERLEY, Mark; CARDOZO, Francisco M. Malta; YU, Pai C.; GUALANDRO, Danielle; CASELLA, Ivan B.; SILVA, Erasmo; CARAMELLI, Bruno; CALDERARO, Daniela