JULIA THIEMI TAKIUTI
Índice h a partir de 2011
8
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Structural disease progression in PDE6-associated autosomal recessive retinitis pigmentosa(2018) TAKAHASHI, Vitor K. L.; TAKIUTI, Julia T.; JAUREGUI, Ruben; LIMA, Luiz H.; TSANG, Stephen H.Background and objective: To evaluate the progression of retinitis pigmentosa (RP) caused by mutations in either PDE6A or PDE6B by measuring the progressive constriction of the hyperautofluorescent ring and shortening of the ellipsoid zone (EZ)-line width. Patients and methods: Fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) images were obtained from seven patients with autosomal recessive RP caused by mutations in either PDE6A or PDE6B. Measurements of the EZ line width on SD-OCT images and horizontal, vertical diameter, and ring area on FAF images were performed by two independent graders. The measurements of these four parameters were correlated with one another. Results: We observed that the EZ line width decreased by an average of 91 +/- 64 mu m per year, while the horizontal and vertical diameters decreased by 103 +/- 53 mu m and 92 +/- 49 mu m per year, respectively. The ring area decreased by a rate of 0.3 +/- 0.18 mm(2) per year. Progression rates were similar for the left eye. Conclusions: We observed a progressive loss of EZ line width and Short-wavelength fundus autofluorescence (SW-AF) ring constriction over time. These results may serve as reference for better prognostic prediction and patients selection for clinical trials promoting cone rescue.
- Comparison of structural progression between ciliopathy and non-ciliopathy associated with autosomal recessive retinitis pigmentosa(2019) TAKAHASHI, Vitor K. L.; XU, Christine L.; TAKIUTI, Julia T.; APATOFF, Mary Ben L.; DUONG, Jimmy K.; MAHAJAN, Vinit B.; TSANG, Stephen H.BackgroundTo evaluate and compare the progression of ciliopathy and non-ciliopathy autosomal recessive Retinitis Pigmentosa patients (arRP) by measuring the constriction of hyperautofluorescent rings in fundus autofluorescence (FAF) images and the progressive shortening of the ellipsoid zone line width obtained by spectral-domain optical coherence tomography (SD-OCT).ResultsFor the ciliopathy group, the estimated mean shortening of the ellipsoid zone line was 259 mu m per year and the ring area decreased at a rate of 2.46mm(2) per year. For the non-ciliopathy group, the estimated mean shortening of the ellipsoid zone line was 84 mu m per year and the ring area decreased at a rate of 0.7mm(2) per year.ConclusionsOur study was able to quantify and compare the loss of EZ line width and short-wavelength autofluorescence (SW-AF) ring constriction progression over time for ciliopathy and non-ciliopathy arRP genes. These results may serve as a basis for modeling RP disease progression, and furthermore, they could potentially be used as endpoints in clinical trials seeking to promote cone and rod survival in RP patients.
- Correlation between B-scan optical coherence tomography, en face thickness map ring and hyperautofluorescent ring in retinitis pigmentosa patients(2019) TAKAHASHI, Vitor K. L.; TAKIUTI, Julia T.; JAUREGUI, Ruben; XU, Christine L.; DUONG, Jimmy K.; LIMA, Luiz H.; TSANG, Stephen H.ObjectiveTo evaluate and compare the B-scan OCT loss of ellipsoid zone, OCT en face thickness map constriction, and hyperautofluorescent ring constriction in RP patients.MethodsRetrospective case series study. Forty-eight eyes of 24 RP patients with a parafoveal hyperautofluorescent ring were studied. The diagnosis of RP was established by the presence of rod response impairment and a prevalent decrease of scotopic over photopic responses on electroretinography. The FAF and spectral-domain optical coherence tomography (SD-OCT) images were obtained from 24 patients with RP. The measurements of the EZ line width on B-scan OCT, hyperautofluorescent ring area on FAF, and hyperautofluorescent ring area on en face thickness map were performed by two independent graders. The measurements of these three parameters were correlated.ResultsThe mean age of study patients was 46years old (sd=19). The external and internal FAF rings involving the fovea were identified in all study eyes. The area of the thickness ring decreased at an average rate of 0.5 (sd 0.4) mm(2) per year (P<0.001). The average rate of EZ-line constriction was estimated to be 123 (sd 63) mu m per year (P<0.001). The hyperautofluorescent ring area decreased at an average rate of 0.9 (sd 0.98) mm(2) per year (P<0.001). The strongest correlation was observed between hyperautofluorescent ring area and EZ-line width (r=0.78).ConclusionsWe observed that the hyperautofluorescent ring area exhibits a faster progression rate than the area of the thickness ring. In addition, we found that the EZ-line width had a high positive correlation with the hyperautofluorescent ring area and a moderate positive correlation with area of the thickness ring.