BRUNO ZILBERSTEIN
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Gastroenterologia, Faculdade de Medicina - Docente
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- Imagine a world without cancer(2014) BRUECHER, Bjoern L. D. M.; LYMAN, Gary; HILLEGERSBERG, Richard van; POLLOCK, Raphael E.; LORDICK, Florian; YANG, Han-Kwang; USHIJIMA, Toshikazu; YEOH, Khay-Guan; SKRICKA, Tomas; POLKOWSKI, Wojciech; WALLNER, Grzegorz; VERWAAL, Vic; GAROFALO, Alfredo; D'UGO, Domenico; ROVIELLO, Franco; STEINAU, Hans-Ulrich; WALLACE, Timothy J.; DAUMER, Martin; MAIHLE, Nitah; III, Thomas J. Reid; DUCREUX, Michel; KITAGAWA, Yuko; KNUTH, Alexander; ZILBERSTEIN, Bruno; STEELE, Scott R.; JAMALL, Ijaz S.Background: Since the ""War on Cancer"" was declared in 1971, the United States alone has expended some $300 billion on research, with a heavy focus on the role of genomics in anticancer therapy. Voluminous data have been collected and analyzed. However, in hindsight, any achievements made have not been realized in clinical practice in terms of overall survival or quality of life extended. This might be justified because cancer is not one disease but a conglomeration of multiple diseases, with widespread heterogeneity even within a single tumor type. Discussion: Only a few types of cancer have been described that are associated with one major signaling pathway. This enabled the initial successful deployment of targeted therapy for such cancers. However, soon after this targeted approach was initiated, it was subverted as cancer cells learned and reacted to the initial treatments, oftentimes rendering the treatment less effective or even completely ineffective. During the past 30 plus years, the cancer classification used had, as its primary aim, the facilitation of communication and the exchange of information amongst those caring for cancer patients with the end goal of establishing a standardized approach for the diagnosis and treatment of cancers. This approach should be modified based on the recent research to affect a change from a service-based to an outcome-based approach. The vision of achieving long-term control and/or eradicating or curing cancer is far from being realized, but not impossible. In order to meet the challenges in getting there, any newly proposed anticancer strategy must integrate a personalized treatment outcome approach. This concept is predicated on tumor-and patient-associated variables, combined with an individualized response assessment strategy for therapy modification as suggested by the patient's own results. As combined strategies may be outcome-orientated and integrate tumor-, patient-as well as cancer-preventive variables, this approach is likely to result in an optimized anticancer strategy. Summary: Herein, we introduce such an anticancer strategy for all cancer patients, experts, and organizations: Imagine a World without Cancer.
- Oncological Robot-Assisted Gastrectomy: Technical Aspects and Ongoing Data(2020) BARCHI, Leandro Cardoso; SOUZA, Willy Petrini; FRANCISS, Maurice Youssef; RAMOS, Marcus Fernando Kodama Pertille; DIAS, Andre Roncon; HYUNG, Woo Jin; ZILBERSTEIN, BrunoRobotic surgery through the da Vinci Surgical System has been widely spread for many procedures across the globe for several years. At the same time, robot-assisted gastrectomy for gastric cancer (GC) remains mostly available only in specialized centers in minimally invasive surgery and stomach neoplasm. The robotic platform has been introduced to overcome possible drawbacks of the laparoscopic approach. The safety and the feasibility of robotic radical gastrectomy have been reported in many retrospective case series and nonrandomized prospective studies. However, the superiority of robotic gastrectomy over the laparoscopic access has not yet been proven. This study aimed to report the technical aspects of robot-assisted gastrectomy for GC as well as the latest evidence on this subject.