MARCELO BISCEGLI JATENE
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina - Líder
7 resultados
Resultados de Busca
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- Holt-Oram syndrome: novel TBX5 mutation and associated anomalous right coronary artery(2011) VIANNA, Caio B.; MIURA, Nana; PEREIRA, Alexandre C.; JATENE, Marcelo B.The Holt-Oram syndrome was confirmed in an asymptomatic 36-year-old man by a novel TBX5-gene mutation (exon 8 acceptor splicing site, c.663-1G greater than A). Computed tomography showed an atrial septal defect and an anomalous right coronary artery crossing between the aorta and pulmonary arteries. Surgery corrected the septal defect and the initial segment of the anomalous vessel was unroofed and enlarged. Anomalous coronary arteries were not previously described in the Holt-Oram syndrome patients and should be added to the list of possible associated cardiac defects.
- Risk factors for death or mechanical ventilation time after bidirectional cavopulmonary anastomosis in a developing country(2022) JONAS, Marina C.; CARMONA, Fabio; CANEO, Luiz F.; TURQUETTO, Aida L. R.; JATENE, Marcelo B.; MANSO, Paulo H.Background: Glenn procedure is performed for patients with cyanotic CHD and univentricular physiology and has a survival rate above 90%. Aim: To evaluate the risk factors associated with a poor outcome after Glenn procedure. Methods: The data for this retrospective analysis were collected from a regional Brazilian registry of congenital heart surgeries (ASSIST initiative) from 2014 to 2019. Data from 97 patients who underwent the Glenn procedure were considered. The primary outcomes were prolonged mechanical ventilation (>24 hours post-operatively) or in-hospital death, alone and combined. Results: The overall in-hospital mortality was 13.4% (n = 13). Prolonged mechanical ventilation occurred in 52% (n = 51) of the patients. Our analysis found that risk factors for death or prolonged post-operative mechanical ventilation were cardiopulmonary bypass duration and post-operative lactate, whereas weight-for-age z-score and age at surgery were risk factors for prolonged mechanical ventilation. Cardiopulmonary bypass duration increased (adjusted odds ratio: 1.02; 95 % CI: 1.01, 1.03) and age at surgery decreased (adjusted odds ratio: 0.96; 95 % CI: 0.93, 0.99) the odds of the combined outcome. Conclusions: Age at surgery, post-operative lactate, and low-weight-for-age z-score are associated with prolonged mechanical ventilation and death following the Glenn procedure.
- COVID-19 pandemic implications in paediatric and congenital heart surgery in Brazil(2022) MIANA, Leonardo A.; MANUEL, Valdano; ANTONIALI, Fernando; JATENE, Marcelo B.; JATENE, Fabio BiscegliIntroduction: The Coronavirus Disease 2019 (COVID-19) pandemic negatively impacted global healthcare. Consequences in Pediatric and Congenital Heart Surgery programmes and mortality of congenital heart patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) is still to be determined. Objective: To study the COVID-19 pandemic implications in Brazilian Pediatric and Congenital Heart Surgery programmes. Methods: We conducted a national online survey covering all states that perform Pediatric and Congenital Heart Surgery from 10 November to 22 November, 2020, using a Google forms questionnaire. We formulated questions related to impact on surgical volume, case-mix, and mortality. Then we asked about short-term post-operative COVID-19 infection and outcomes. Results: We received responses from 46 centres representing all states where there were a Pediatric and Congenital Heart Surgery programme and all high-volume centres across the country. All but one centre experienced a significant decrease in surgical volume, and 23.9% of the responders revealed less than one-quarter of volume decrement. On the other hand, in over 70% of the centres, there was a significant surgical volume reduction. In addition to this, there was a shift in case-mix in 41 centres (89.1%) towards more complex cases. More than one-third of the responders revealed increased mortality in 2020 compared to previous years, and 43.5% of the programmes (20 centres) had at least one patient contaminated by SARS-Cov-2, accounting for 48 patients. Mortality in post-operative infected patients was 45.8% (22 patients). Conclusions: In general, Brazilian Pediatric and Congenital Heart Surgery programmes were severely affected by decreased surgical volume, unbalanced case-mix towards more complex cases, and increased mortality. Almost half of the programmes related post-operative COVID-19 contamination with high mortality.
- Advocacy at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery(2023) ZHELEVA, Bistra; VERSTAPPEN, Amy; OVERMAN, David M.; AHMAD, Farhan; ALI, Sulafa K. M.; HALEES, Zohair Y. Al; ATALLAH, Joumana Ghandour; BADHWAR, Isabella E.; BAKER-SMITH, Carissa; BALESTRINI, Maria; BASKEN, Amy; BASSUK, Jonah S.; BENSON, Lee; CAPELLI, Horacio; CAROLLO, Santo; CHOWDHURY, Devyani; CICEK, M. Sertac; COHEN, Mitchell I.; COOPER, David S.; DEANFIELD, John E.; DEARANI, Joseph; VALLE, Blanca del; DODDS, Kathryn M.; DU, Junbao; EDWIN, Frank; EKURE, Ekanem; FATEMA, Nurun Nahar; GOMANJU, Anu; HASAN, Babar; HENRY, Lewis; HUGO-HAMMAN, Christopher; IYER, Krishna S.; JATENE, Marcelo B.; JENKINS, Kathy J.; KARAMLOU, Tara; KARL, Tom R.; KIRKLIN, James K.; KREUTZER, Christian; KUMAR, Raman Krishna; LOPEZ, Keila N.; MACEDO, Alexis Palacios; MARINO, Bradley S.; MARWALI, Eva M.; MEIJBOOM, Folkert J.; MATTOS, Sandra S.; NAJM, Hani; NEWLIN, Dan; NOVICK, William M.; QURESHI, Sir Shakeel A.; RAHMAT, Budi; RAYLMAN, Robert; SALTIK, Irfan Levent; SABLE, Craig; SANDOVAL, Nestor; SAXENA, Anita; SCANLAN, Emma; SHOLLER, Gary F.; SMITH, Jodi; LOUIS, James D. St; TCHERVENKOV, Christo I.; TIONG, Koh Ghee; VIDA, Vladimiro; VOSLOO, Susan; WEINSTEIN, Douglas J. D. J.; WILKINSON, James L.; ZUHLKE, Liesl; JACOBS, Jeffrey P.The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery (WCPCCS) will be held in Washington DC, USA, from Saturday, 26 August, 2023 to Friday, 1 September, 2023, inclusive. The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery will be the largest and most comprehensive scientific meeting dedicated to paediatric and congenital cardiac care ever held. At the time of the writing of this manuscript, The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery has 5,037 registered attendees (and rising) from 117 countries, a truly diverse and international faculty of over 925 individuals from 89 countries, over 2,000 individual abstracts and poster presenters from 101 countries, and a Best Abstract Competition featuring 153 oral abstracts from 34 countries. For information about the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery, please visit the following website: [www.WCPCCS2023.org]. The purpose of this manuscript is to review the activities related to global health and advocacy that will occur at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery.Acknowledging the need for urgent change, we wanted to take the opportunity to bring a common voice to the global community and issue the Washington DC WCPCCS Call to Action on Addressing the Global Burden of Pediatric and Congenital Heart Diseases. A copy of this Washington DC WCPCCS Call to Action is provided in the Appendix of this manuscript. This Washington DC WCPCCS Call to Action is an initiative aimed at increasing awareness of the global burden, promoting the development of sustainable care systems, and improving access to high quality and equitable healthcare for children with heart disease as well as adults with congenital heart disease worldwide.
- The role of the neutrophil-lymphocyte ratio for pre-operative risk stratification of acute kidney injury after tetralogy of Fallot repair(2021) MANUEL, Valdano; MIANA, Leonardo A.; TURQUETTO, Aida; GUERREIRO, Gustavo Pampolha; FERNANDES, Natalia; JATENE, Marcelo BiscegliIntroduction: Acute kidney injury is a risk factor for chronic kidney disease and mortality after congenital heart surgery under cardiopulmonary bypass. The neutrophil-lymphocyte ratio is an inexpensive and easy to measure biomarker for predicting outcomes in children with congenital heart disease undergoing surgical correction. Objective: To identify children at high risk of acute kidney injury after tetralogy of Fallot repair using the neutrophil-lymphocyte ratio. Methods: This single-centre retrospective analysis included consecutive patients aged < 18 years who underwent tetralogy of Fallot repair between January 2014 and December 2018. The pre-operative neutrophil-lymphocyte ratio was measured using the last pre-operative complete blood count test. We used the Acute Kidney Injury Network definition. Results: A total of 116 patients were included, of whom 39 (33.6%) presented with acute kidney injury: 20 (51.3%) had grade I acute kidney injury, nine had grade II acute kidney injury (23.1%), and 10 (25.6%) had grade III acute kidney injury. A high pre-operative neutrophil-lymphocyte ratio was associated with grade III acute kidney injury in the post-operative period (p = 0.04). Patients with acute kidney injury had longer mechanical ventilation time (p = 0.023), intensive care unit stay (p < 0.001), and hospital length of stay (p = 0.002). Conclusion: Our results suggest that the pre-operative neutrophil-lymphocyte ratio can be used to identify patients at risk of developing grade III acute kidney injury after tetralogy of Fallot repair.
- Early presentation of endomyocardial fibrosis(2011) AIELLO, Vera D.; JATENE, Marcelo B.
- Predictive value of pre-operative neutrophil-lymphocyte ratio for children undergoing congenital heart surgery(2020) MANUEL, Valdano; MIANA, Leonardo A.; JATENE, Marcelo B.