JOSE CLAUDIO MENEGHETTI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
conferenceObject A decrease in glycolytic metabolism in noncompaction cardiomyopathy - Insights into pathophysiological mechanisms(2016) MELO, M. Dantas Tavares De; GIORGI, M. Clementina; DANTAS JUNIOR, R. Nery; LIMA, C. Rocon De; PARGA FILHO, J. Roberto; SOARES JUNIOR, J.; MENEGHETTI, J. Claudio; BIERRENBACH, A. Luiza; BOCCHI, E. Alcides; SALEMI, V. M. C.conferenceObject 18F-FDG PET/CT Findings vs. Histology of Surgically Resected Cardiac Valves in Patients With Infective Endocarditis.(2018) CAMARGO, Raphael A.; CASTELLI, Jussara B.; BITTENCOURT, Marcio S.; AYABE, Daniel; PAIXAO, Milena R.; FELICIO, Marilia F.; SOEIRO, Alexandre M.; GONCALVES, Luis Fernando T.; V, Tania Strabelli; SOARES JR., Jose; BUCHPIGUEL, Carlos A.; MANSUR, Alfredo J.; TARASOUTCHI, Flavio; OLIVEIRA JR., Mucio T.; MENEGHETTI, Claudio; GUALANDRO, Daniele M.; POCEBON, Lucas; BLANKSTEIN, Ron; ALAVI, Abass; SICILIANO, Rinaldo F.conferenceObject Negative Interim PET Consistently Predicts for Better Outcome of DLBCL in an IAEA-Sponsored Multi-national Study(2012) PAEZ, D.; FANTI, S.; MENEGHETTI, J. C.; GYOERKE, T.; MONETA, F. R.; AUEWARAKUL, C. U.; NAIR, R.; VIADO-GOROSPE, C.; KUCUK, O.; MORRIS, T. P.; PADUA, R. A.; CERCI, J. J.; CARR, R.Aim The role of interim PET (i-PET) as a predictor of outcome in patients with diffuse large B-cell lymphoma (DLBCL) remains uncertain, with conflicting conclusions reported from studies of between 28 to 121 patients. Most report single centre experience in Western Europe or North America where clinical PET is well established. Variation in Rituximab use or timing of i-PET are suggested as explanation for inconsistent results. We hypothesised that such inconsistency might be greater in non-Western countries, where ethnicity and environmental factors might affect disease biology, and advanced disease alter rate of response. To address this and inform clinical practice in countries where PET has been more recently introduced, we devised a prospective international cohort study with the International Atomic Energy Agency (IAEA). We report interim results from all nine countries. Methods Within participating countries (Brazil, Chile, Hungary, India, Italy, Philippines, Thailand, Turkey, Korea) all patients were scanned in a single PET centre. Permitted treatment was R-CHOP or CHOP (12%). All had pre-treatment staging PET-CT, or CT and PET scans. Clinical factors comprising IPI and bulky disease were recorded. i-PET was after 2nd or 3rd(33%) cycle of chemotherapy. i-PET was classified as negative, minimal residual uptake (MRU), partial response (PR) or progressive disease (PD); negative and MRU were classified as i-PETnegative, PR and PD as i-PET-positive. All MRU and PR scans were centrally reviewed. End treatment PET confirmed clinical response. Treatment change in response to i-PET was not permitted, unless treatment failure was confirmed. Results 395 patients aged 16-83 years were recruited. Individual countries recruited between 9 and 72 (median 50) cases, 54 were excluded from analysis because of death before i-PET or major protocol violation. i-PET was negative in 220 (145 negative, 75 MRU) and positive in 121. At median 20.5 months follow up, disease progression had occurred in 12 (5%) subjects with negative i-PET, 43 (36%) with positive i-PET. Estimated 2 year EFS: i-PET-negative 90% (95%CI 85-94%), i-PET-positive 59% (49-68%); hazard ratio from a multivariable model was 4.9 (95% CI 2.8-8.6). We observed no evidence that recruiting country influenced the prognostic value of i-PET. Conclusion This large study confirms early i-PET as a consistent independent predictor of outcome in patients with DLBCL. The ability of i-PET to predict treatment outcome is generalisable to non-western populations and healthcare systems.- Calculation of Cardiac Kinetic Energy Index from PET images(2015) SIMS, John; OLIVEIRA, Marco Antonio; MENEGHETTI, Jose Claudio; GUTIERREZ, Marco AntonioCardiac function can be assessed from displacement measurements in imaging modalities from nuclear medicine Using positron emission tomography (PET) image sequences with Rubidium-82, we propose and estimate the total Kinetic Energy Index (KO) obtained from the velocity field, which was calculated using 3D optical flow(OF) methods applied over the temporal image sequence. However, it was found that the brightness of the image varied unexpectedly between frames, violating the constant brightness assumption of the OF method and causing large errors in estimating the velocity field. Therefore total brightness was equalized across image frames and the adjusted configuration tested with rest perfusion images acquired from individuals with normal (n=30) and low (n=33) cardiac function. For these images KEf was calculated as 0.5731 +/- 0.0899 and 0.3812 +/- 0.1146 for individuals with normal and low cardiac function respectively. The ability of KEf to properly classes patients into the two groups was tested with a ROC analysis, with area under the curve estimated as 0.906. To our knowledge this is the first time that KEf has been applied to PET images.
conferenceObject Coronary flow reserve but not ischemia is a strong predictor of mortality in 551 outpatients referred for stress myocardial perfusion by Rubidium-82 PET imaging(2019) POPPI, N. Tavares; SOARES JUNIOR, J.; MENEGHETTI, J. C.; MIOTO, B. Mahler; GIORGI, M. C. P.; IZAKI, M.; CESAR, L. A. MachadoconferenceObject INFLUENCE OF LEFT BUNDLE BRANCH BLOCK IN ASSESSMENT OF MYOCARDIAL BLOOD FLOW FROM RUBIDIUM 82 POSITRON EMISSION TOMOGRAPHY IMAGING(2015) FALCAO, Andrea; CHALELA, William; GIORGI, Maria; IMADA, Rodrigo; SOARES JR., Jose; IZAKI, Marisa; KALIL-FILHO, Roberto; MENEGHETTI, Jose C.conferenceObject Myocardial perfusion scintigraphy (Gated-SPECT) in patients with ischemic ST-segment only during recovery phase of the exercise testing(2013) FALCAO, A.; CHALELA, W. A.; IMADA, R.; IRABI, R.; AZOURI, L. O.; COSTA, M.; KALIL FILHO, R.; RAMIRES, J. A. F.; MENEGHETTI, J. C.; BORGES-NETO, S.conferenceObject Double-Blind, Placebo-Controlled, Randomized Trial of Stem Cell Therapy Combined With Bypass Surgery - The MiHeart Trial(2018) GOWDAK, Luis Henrique W.; SCHETTERT, Isolmar T.; MENEGHETTI, Jose Claudio; ROCHITTE, Carlos Eduardo; DALLAN, Luis Alberto O.; GUARITA-SOUZA, Luiz Cesar; BRITO, Jose Oscar R.; CESAR, Luiz Antonio M.; OLIVEIRA, Sergio A. de; CARVALHO, Antonio Carlos C. de; KRIEGER, Jose EduardoconferenceObject FDG-PET initial staging in Hodgkin lymphoma patients has impact on 5-year overall and event free survival(2012) CERCI, Juliano; LINARDI, Camila; PRACCHIA, Luis; SOARES, Jose; TRINDADE, Evelinda; CERCI, Rodrigo; DELBEKE, Dominique; MENEGHETTI, JoseconferenceObject Diagnostic value of Positron emission tomography (PET/CT) in native and prosthetic infective endocarditis(2017) CAMARGO, R. A.; SICILIANO, R. F.; PAIXAO, M. R.; SOEIRO, A. M.; SOARES JR., J.; FELICIO, M. F.; STRABELLI, T. M. V.; BUCHPIGUEL, C. A.; ALAVI, A.; TONELLO, L.; MANSUR, A. J.; TARASOUTCHI, F.; OLIVEIRA JR., M. T.; MENEGHETTI, J. C.