ROSSANA PULCINELI VIEIRA FRANCISCO

(Fonte: Lattes)
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Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina - Líder

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Agora exibindo 1 - 10 de 38
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    Effects of Human Amniotic Fluid Stem Cells in a Model of Aorta Allograft Vasculopathy
    (2012) SANTANA, A. C.; DELLE, H.; CAVAGLIERI, R. C.; LOPES, M. A. B.; FRANCISCO, R. P. V.; ZUGAIB, M.; BYDLOWSKI, S. P.; NORONHA, I. L.
    Chronic allograft vasculopathy (CAV) is an important cause of graft loss. Considering the immune-in flammatory events involved in the development of CAV, therapeutic approaches to target this process are of relevance. Human amniotic fluid derived stem cells (hAFSC), a class of fetal, pluripotent stem cells with intermediate characteristics between embryonic and adult stem cells display immunomodulatory properties. hAFSC express mesenchymal and embryonic markers, show high proliferation rates, but do not induce tumor formation and their use does not raise ethical issues. Thus, we sought to investigate the effect of hAFSC on CAV in a model of aorta transplantation. Orthotopic aorta transplantation was performed using Fisher (F344) rats as donors and Lewis rats as recipients. Rats were divided into 3 groups: syngeneic (SYNG), untreated F344 receiving aorta from F344 (n=8); allogeneic (ALLO), Lewis rats receiving allogeneic aorta from F344 (n=8); and ALLO+hAFSC, ALLO rats treated with hAFSC (106 cells) (n=8). Histological analysis and immunohistochemistry were performed 30 days post transplantation. ALLO developed a robust aortic neointimal formation, accompanied by a high number of ED1+ and CD43+ cells, and enhanced expression of α-SMA in theneointima. Treatment with hAFSC diminished neointimal thickness and induced a significant decrease of ED1+, CD43+ cells and α-SMA expression in the neointima. Comparative analyses in the differents groups PARAMETERS SYNG ALLO ALLO+hAFSC Neointima thickness (μm) 0±0 208.7±25.4* 180.7±23.7* ED-1+ (cells/mm2) 0±0 4.845±841* 1.100±276*, #CD43+ (cells/mm2) 0±0 4.064±563* 1.080±309*,#α-SMA (%) 0±0 25±6* 8±3*, #*p<0.05 vs. SYNG; #P<0.05 vs. ALLO These preliminary results showed that hAFSC suppressed inflammation and myofibroblast migration to the intima, which may contribute to ameliorate vascular changes in CAV.
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    Longitudinal serum levels of Placental Growth Factor and sFlt-1 throughout gestation in normotensive pregnancies and those complicated by hypertensive disorders
    (2013) COSTA, R. A.; HOSHIDA, M. S.; ALVES, E. A.; V, R. P. Francisco; ZUGAIB, M.
    Background: Preeclampsia (PE) prevalence is higher in women with chronic hypertension (CH). Predictive markers for PE in this group could be particularly important. We aimed to evaluate serum levels of PlGF and sFlt-1 throughout pregnancies complicated by isolated PE, CH and PE superimposed on CH (PE+CH) compared to normotensive (NT) pregnancies. Methods: Peripheral blood samples have been collected from NT and CH pregnancies at gestational ages of 20, 26, 32 and 36 weeks and stored to be assayed by ELISA. This study was approved by local Ethics Committee. To date, samples have been partially assayed. Results: Levels of sFlt-1 increased throughout pregnancy in all groups. Levels of PlGF increased until 32 weeks in pregnancies not complicated by PE (NT and CH) and until 26 weeks in those complicated by PE (PE and PE+HC), thereafter PlGF levels decreased in all groups. Conclusions: preliminary data, still too short for statistical testing.
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    Glycemic Control and Fetal Growth in Patients With Gestational Diabetes
    (2012) TRINDADE, Thatianne C.; FRANCISCO, Rossana P.; ZUGAIB, Marcelo
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    EFFECT OF THE MICROENVIRONMENT ON THE PLACENTAL BEHAVIOUR: RESPONSE OF THE CHORIONIC VILLI TO NORMAL AND PREECLAMPTIC PREGNANT SERUM
    (2017) PRADO, Karen; CASTRO, Karla; LORENZON-OJEA, Aline; CARDOSO, Elaine; HOSHIDA, Mara; ALVES, Eliane; FRANCISCO, Rossana P. Vieira; ZUGAIB, Marcelo; BEVILACQUAL, Estela
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    Descriptive analysis of pregnant women with recurrent fetal death and thrombophilia
    (2014) ANDRES, M. D. P.; IGAI, A. M. K.; BARROS, V; FRANCISCO, R. P.; ZUGAIB, M.
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    Placental abruption and thrombophilia
    (2013) ARISSA, K.; BARROS, V. V.; BAPTISTA, F. S.; BORTOLOTTO, M. R. D. F. L.; V, R. P. Francisco; ZUGAIB, M.
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    EXPRESSION OF HLA-G, HLA-E AND HLA-F IN THE CHORIODECIDUAL INTERFACE OF COMPLETE HYDATIDIFORM MOLES
    (2019) LIN, Lawrence; TOSCANO, Marcello; HOSHIDA, Mara; SCHULTZ, Regina; FUSHIDA, Koji; FRANCISCO, Rossana
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    Palliative Care After Prenatal Diagnosis of Life-limiting Malformations: A Model of Care
    (2018) BERNARDES, Lisandra Stein; GIBELLI, Maria Augusta B. C.; FIGUEIREDO, Fernanda; BERTOLASSI, Nathalia; BARBOSA, Tercilia; BOLIBIO, Renata; GOMES, Ana; JESUS, Roberta; VILHEGAS, Andresa; ROCHA, Luana; ROSA, Gladys; SETUBAL, Maria Silvia; BENUTE, Glaucia; FRANCISCO, Rossana
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    Preconception women's dietary intake of nutrients from one-carbon metabolism pathway: has it effects on birth weight?
    (2015) TEIXEIRA, Juliana Araujo; CASTRO, Ana Lucia da Silva; FRANCISCO, Rossana Pulcineli Vieira; VIEIRA, Sandra Elisabete; SALDIVA, Silvia Regina Dias Medici; MARCHIONI, Dirce