BRUNA MIRANDA DE OLIVEIRA SILVA

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    LIPID TRANSFERS TO HDL ARE DIMINISHED IN WOMEN WITH OVERT HYPOTHYROIDISM AFTER TOTAL THYROIDECTOMY
    (2018) SIGAL, A.; TAVONI, T. M.; FREITAS, F. R.; SILVA, B. M. O.; BRANDAO, L. G.; MARANHAO, R. C.
  • conferenceObject
    PLASMA LIPIDS AND LIPID TRANSFER TO HDL IN LONG-TERM BEDRIDDEN AND IN SEDENTARY SUBJECTS
    (2017) MARANHAO, Raul Cavalcante; OLIVEIRA, Wilson Camargo De; TAVONI, Thauany Martins; FREITAS, Fatima Rodrigues; SILVA, Bruna Miranda; KALIL-FILHO, Roberto
  • article 2 Citação(ões) na Scopus
    Lipid transfers to HDL are diminished in long-term bedridden patients: association with low HDL-cholesterol and increased inflammatory markers
    (2017) OLIVEIRA, Wilson Pascoalino Camargo de; TAVONI, Thauany Martins; FREITAS, Fatima Rodrigues; SILVA, Bruna Miranda Oliveira; MARANHAO, Raul Cavalcante
    Plasma lipids have been extensively studied in sedentary and in subjects practicing exercise training, but not in extreme inactivity as occurs in bedridden patients. This is important for the care of bedridden patients and understanding the overall plasma lipid regulation. Here, we investigated plasma lipids, lipid transfers to HDL and inflammatory markers in bedridden patients. Fasting blood samples were collected from 23 clinically stable bedridden patients under long-term care (> 90 days) and 26 normolipidemic sedentary subjects, paired for age and gender. In vitro transfer of four lipids to HDL was performed by incubating plasma with donor nanoparticles containing radioactive lipids. Total (193 +/- 36 vs 160 +/- 43, p = 0.005), LDL (124 +/- 3 vs 96 +/- 33 p = 0.003) and HDL-cholesterol (45 +/- 10 vs 36 +/- 13, p = 0.008), apolipoprotein A-I (134 +/- 20 vs 111 +/- 24, p = 0.001) and oxidized LDL (53 +/- 13 vs 43 +/- 12, p = 0.011) were lower in bedridden patients, whereas triglycerides, apolipoprotein B, CETP and LCAT were equal in both groups. Transfers of all lipids, namely unesterified cholesterol, cholesterol esters, triglycerides and phospholipids, to HDL were lower in bedridden patients, probably due to their lower HDL-cholesterol levels. Concentrations of IL-1 beta, IL-6, IL-8, HGF and NGF were higher in bedridden patients compared to sedentary subjects. In conclusion, inactivity had great impact on HDL, by lowering HDL-cholesterol, apolipoprotein A-I and thereby cholesterol transfers to the lipoprotein, which suggests that inactivity may deteriorate HDL protection beyond the ordinary sedentary condition.
  • article 13 Citação(ões) na Scopus
    Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure
    (2018) MARTINELLI, Ana Elisa M.; MARANHAO, Raul C.; CARVALHO, Priscila O.; FREITAS, Fatima R.; SILVA, Bruna M. O.; CURIATI, Milena N. C.; KALIL FILHO, Roberto; PEREIRA-BARRETTO, Antonio Carlos
    BackgroundHeart failure (HF) courses with chronic inflammatory process and alterations in lipid metabolism may aggravate the disease. The aim was to test whether the severity of HF, using brain natriuretic peptide (BNP) as a marker, is associated with alterations in functional aspects of HDL, such as lipid transfer, cholesterol ester transfer protein (CETP) and lecithin-cholesterol acyltransferase (LCAT) concentration.MethodsTwenty-five HF patients in NYHA class I/II and 23 in class III/IV were enrolled. Plasma lipids, apolipoproteins, CETP, LCAT, oxidized-LDL (oxLDL) and paraoxonase-1 (PON-1) activity were determined. Lipid transfer from a donor artificial nanoparticle to HDL was measured by in vitro assay.ResultsTotal cholesterol (p=0.049), LDL-C (p=0.023), non-HDL-C (p=0.029) and CETP, that promotes lipid transfer among lipoproteins (p=0.013), were lower in III/IV than in I/II group. Triglycerides, HDL-C, apo A-I, apo B, oxLDL, LCAT, enzyme that catalyzes serum cholesterol esterification, PON-1 activity, and in vitro transfers of cholesterol, triglycerides and phospholipids to HDL, important steps in HDL metabolism, were equal. IL-8 was higher in III/IV (p=0.025), but TNF, IL-1, IL-6 and MCP-1 were equal. BNP was negatively correlated with CETP (r=-0.294; p=0.042) and positively correlated with IL-8 (r=0.299; p=0.039).ConclusionsOur results disclosed the relationship between CETP levels and HF severity, by comparing two HF groups and by correlation analysis. Lower CETP levels may be a marker of HF aggravation and possibly of worse prognosis. Practical applications of this initial finding, as the issue whether CETP could be protective against HF aggravation, should be explored in larger experimental and clinical studies.