JURACI APARECIDA ROCHA
Projetos de Pesquisa
Unidades Organizacionais
PAHC, Hospital das Clínicas, Faculdade de Medicina - Médico
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- Criterion validity and inter-rater reliability o a palliative care screening tool for patients admitted to an emergency department intensive care unit(2018) RIBEIRO, Sabrina Correa da Costa; CARVALHO, Ricardo Tavares de; ROCHA, Juraci Aparecida; DIAS, Roger DagliusObjective. The use of palliative care (PC) screening criteria to trigger PC consultations may optimize the utilization of PC services, improve patient comfort, and reduce invasive and futile end-of-life care. The aim of the present study was to assess the criterion validity and inter-rater reliability of a PC screening tool for patients admitted to an emergency department intensive care unit (ED-ICU). Method. Observational retrospective study evaluating PC screening criteria based on the presence of advanced diagnosis and the use of two ""surprise questions"" (traditional and modified). Patients were classified at ED-ICU admission in four categories according to the proposed algorithm. Result. A total of 510 patients were included in the analysis. From these, 337 (66.1%) were category 1, 0 (0.0%) category 2, 63 (12.4%) category 3, and 110 (21.6%) category 4. Severity of illness (Simplified Acute Physiology Score III score and mechanical ventilation), mortality (ED-ICU and intrahospital), and PC-related measures (order for a PC consultation, time between admission and PC consultation, and transfer to a PC bed) were significantly different across groups, more evidently between categories 4 and 1. Category 3 patients presented similar outcomes to patients in category 1 for severity of illness and mortality. However, category 3 patients had a PC consultation ordered more frequently than did category 1 patients. The screening criteria were assessed by two independent raters (n = 100), and a substantial interrater reliability was found, with 80% of agreement and a kappa coefficient of 0.75 (95% confidence interval = 0.62, 0.88). Significance of results. This study is the first step toward the implementation of a PC screening tool in the ED-ICU. The tool was able to discriminate three groups of patients within a spectrum of increasing severity of illness, risk of death, and PC needs, presenting substantial inter-rater reliability. Future research should investigate the implementation of these screening criteria into routine practice of an ED-ICU.
- Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction(2017) BEZERRA, Otavio C.; FRANCA, Cristiane Miranda; ROCHA, Juraci Aparecida; NEVES, Gizele A.; SOUZA, Pamella Ramona M.; GOMES, Mariana Teixeira; MALFITANO, Christiane; LOLEIRO, Tatiane C. Alba; DOURADO, Paulo Magno; LLESUY, Susana; ANGELIS, Katia de; IRIGOYEN, Maria Claudia C.; ULLOA, Luis; CONSOLIM-COLOMBO, Fernanda M.We previously reported that cholinergic stimulation with pyridostigmine (PY) induces anti-inflammatory cell recruitment soon after myocardial infarction (MI). In this study, we evaluated the anti-inflammatory effects of PY during the proliferative phase of cardiac repair by analyzing the infiltration of macrophages, Treg lymphocytes, oxidative stress and inflammatory cytokines. Wistar rats underwent control sham surgery or ligation of the left coronary artery and were randomly allocated to remain untreated (untreated infarcted group, I) or to receive PY (30 mg.kg(-1).day(-1)) in the supplied water (infarcted treated group, I + PY). Blood pressure and heart rate variability were registered at day 5 post-MI. The animals were euthanized 7 days after thoracotomy, when the hearts were removed and processed for immunohistochemistry (CD68, CD206, FOXP3), cytokines (IL-1 beta, IL-6, IL-10, TNF-alpha) and oxidative stress (superoxide dismutase, catalase, glutathione peroxidase, lipidic and protein peroxidation). PY treatment increased parasympathetic modulation, M2 macrophages and the antioxidant enzyme activity but reduced protein oxidation (carbonyls) and the concentration of IL-1 beta, IL-6, TNF-alpha and IL-10. Cholinergic stimulation induces parasympathetic neuro-immune modulation and anti-inflammatory cell enrollment as well as prevents oxidative stress and cytokine production after MI.