JEANNE DA ROSA OITICICA RAMALHO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina
2 resultados
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- Stem-cell therapy for hearing loss: are we there yet?(2019) DUFNER-ALMEIDA, Luiz Gustavo; CRUZ, Dayane Bernardino da; MINGRONI NETTO, Regina Celia; BATISSOCO, Ana Carla; OITICICA, Jeanne; SALAZAR-SILVA, RodrigoIntroduction: Mammalian hair cells and auditory neurons do not show regenerative capacity. Hence, damage to these cell types is permanent and leads to hearing loss. However, there is no treatment that re-establishes auditory function. Regenerative therapies using stem cells represent a promising alternative. Objective: This article aims to review the current literature about the main types of stem cells with potential for application in cell therapy for sensorineural hearing loss, the most relevant experiments already performed in animals, as well as the advances that have been recently made in the field. Methods: Research included the databases PubMed/MEDLINE, Web of Science, Science Direct and SciELO, as well as gray literature. Search strategy included the following main terms: ""stem cells'', ""hair cells'' and ""auditory neurons''. Additionally, the main terms were combined with the following secondary terms: ""mesenchymal'', ""iPS'', ""inner ear'', ""auditory''. The research was conducted independently by three researchers. Results: Differentiation of stem cells into hair cells and auditory neurons has a high success rate, reaching up to 82% for the first and 100% for the latter. Remarkably, these differentiated cells are able to interact with hair cells and auditory neurons of cochlear explants through formation of new synapses. When transplanted into the cochlea of animals with hearing loss, auditory restoration has been documented to date only in deafferented animals. Conclusion: Advances have been more prominent in cases of auditory neuropathy, since partial improvement of auditory nerve conditions through cell-based therapy may increase the number of patients who can successfully receive cochlear implants. (C) 2019 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.
- Recording of tinnitus psychoacoustic measurements: an integrative literature review(2019) GUIJO, Laura Mochiatti; FONSECA, Angela Renata Sarambelli; HORIUTI, Mirella Boaglio; VASCONCELOS, Laura Garcia E.; CARDOSO, Ana Claudia Vieira; OITICICA, JeanneABSTRACT Purpose: to review both the national and international literature as well as to describe the methods used to collect psychoacoustic measurements in tinnitus patients. Methods: the current integrative review was conducted on articles in specialized national and international journals, in both the Portuguese and English languages, available in the PubMed/Medline, BVS - LILACS and SCIELO databases. The following keywords and descriptors were used: hearing, tinnitus, psychoacoustic measurements, acuphenometry, and assessment, in both the Portuguese and English languages. The retrieved articles were read and selected for the review according to the eligibility criteria, which included the use of psychoacoustic measurements in tinnitus patients and the presence of a detailed methodological description of the protocol employed, in individuals with normal hearing and those with hearing loss. Results: a total of 12 articles, in which psychoacoustic measures were used for the characterization and the measurement of tinnitus in individuals with normal hearing and in those with hearing loss, were reviewed. The main findings were associated with the sample characterization and the way in which the psychoacoustic measures were performed. Conclusion:given the grouping of several protocols for tinnitus evaluation, which were determined following an integrative literature review, a great heterogeneity in the methods used to perform psychoacoustic measurements for tinnitus assessment for both clinical and scientific purposes was noted.