JOSE CESAR ROSA NETO
Projetos de Pesquisa
Unidades Organizacionais
BMC, ICB - Docente
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
1 resultados
Resultados de Busca
Agora exibindo 1 - 1 de 1
- The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes(2021) NETO, Jose Cesar Rosa; CALDER, Philip C.; CURI, Rui; NEWSHOLME, Philip; SETHI, Jaswinder K.; SILVEIRA, Loreana S.Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research.